An interventional study of Continuous Passive Motion (CPM) in Joint Contracture, Mechanical Ventilation and ICU-acquired Weakness, sponsored by Shin Kong Wu Ho-Su Memorial Hospital. Completed at 1 site in Taiwan. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-25.
Sponsored by Shin Kong Wu Ho-Su Memorial Hospital · Not applicable, Interventional, and Prevention
Among 23 studies in Muscular Atrophy with a site in Taiwan — 1 open to participants now, 3 under way, 1 of them phase 3. Muscular Atrophy · Taiwan.
Among the 23 studies in Muscular Atrophy with a site in Taiwan, this one is the 22nd largest by enrollment of the 22 interventional ones that give a count, is the only one that started in 2024, is one of 13 with no phase, and was the 21st registered.
413 studies on the registry are indexed under Muscular Atrophy; 77 are open to participants now.
Browse Muscular Atrophy studies →1 of the 23 studies in Muscular Atrophy with a site in Taiwan is open now. Recruiting first, the newest first:
Shin Kong Wu Ho-Su Memorial Hospital · Sites in Taiwan
Ages 18+
A study can be open while its sites in Taiwan have not opened yet or have stopped. Only those recruiting at a site in Taiwan →
Of the 51 Muscular Atrophy studies recruiting now, 25 (49%) set no upper age limit and 12 (24%) stop at 75 or younger; 4 take children under 18; 16 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
23 studies; the count open now beside each. This study's row is marked.
First in 2014; this study’s year is marked. 1 started in 2024.
This study's enrollment of 12 is below the median of 40 across 327 interventional studies indexed under Muscular Atrophy.
Median enrollment 100 across the 22 interventional studies, 600 across the 1 observational. Of the 16 that completed or were terminated, 5 (31%) have results posted.
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8 of 23 have an industry lead sponsor. The 10 most frequent:
Shin Kong Wu Ho-Su Memorial Hospital is the lead sponsor of 65 studies on the registry; 16 are open to participants now.
Shin Kong Wu Ho-Su Memorial Hospital has 2 studies filed under Muscular Atrophy — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 23 studies in Muscular Atrophy with a site in Taiwan, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
The goal of this clinical trial is to learn if continuous passive motion (CPM) helps prevent ankle joint contracture and muscle loss in critically ill, mechanically ventilated ICU patients. It will also evaluate the feasibility and safety of implementing CPM in this population. The main questions it aims to answer are:
Does CPM help preserve ankle dorsiflexion range of motion during immobilization in the ICU?
Can ultrasound measurements detect changes in tibialis anterior muscle condition in response to CPM?
Researchers will compare one ankle receiving CPM to the other ankle without intervention in the same patient to assess differences in joint mobility and muscle morphology.
Participants will:
Receive CPM therapy on one ankle for 30 minutes, twice daily, over a 7-day period or until ICU discharge
Undergo goniometric and ultrasound assessments at baseline and at the end of the intervention
Remain under usual ICU care and monitoring while enrolled in the study
413 studies on the registry are indexed under Muscular Atrophy; 77 are open to participants now.
This study's enrollment of 12 is below the median of 40 across 327 interventional studies indexed under Muscular Atrophy.
Browse Muscular Atrophy studies →Shin Kong Wu Ho-Su Memorial Hospital is the lead sponsor of 65 studies on the registry; 16 are open to participants now.
Compared within Muscular Atrophy, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Critical Illness. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
All participants received continuous passive motion (CPM) therapy on the left ankle once daily for 7 consecutive days during mechanical ventilation. The right ankle served as the within-subject control with no intervention. This single-arm study used a within-subject control design.
Device: Continuous Passive Motion (CPM)
Continuous passive motion was applied to the left ankle joint for 60 minutes per day using a motorized CPM device. The therapy was initiated within 48 ho
Change in Passive Ankle Dorsiflexion Range of Motion (ROM)
Difference in passive ankle dorsiflexion angle between baseline and Day 7, measured using a goniometer. The left (intervention) and right (control) ankles will be compared within each subject. Reported in degrees (°).
Time frame: Baseline and Day 7
Tibialis Anterior Muscle Thickness
Change in muscle thickness of the tibialis anterior as measured by ultrasound. Measurements will be obtained directly from B-mode ultrasound images using the built-in caliper function of the ultrasound machine. Values will be reported in centimeters (cm).
Time frame: Baseline and Day 7
Tibialis Anterior Muscle Cross-section Area
Change in cross-sectional area of the tibialis anterior muscle as measured by ultrasound. Measurements will be obtained directly using the built-in area tracing tool on the ultrasound machine during B-mode imaging. Values will be reported in square centimeters (cm²).
Time frame: Baseline and Day 7
Tibialis Anterior Muscle Pennation Angle
Change in pennation angle of the tibialis anterior muscle as measured from B-mode ultrasound images. Angle will be calculated using ImageJ software from the fascicle orientation relative to the deep aponeurosis. Reported in degrees (°).
Time frame: Baseline and Day 7
Tibialis Anterior Muscle Echointensity
Change in echointensity of the tibialis anterior muscle as measured from B-mode ultrasound images. Echointensity will be quantified using ImageJ software as the mean and standard deviation of grayscale values within a manually selected region of interest (ROI), ranging from 0 (black) to 255 (white). Reported in grayscale arbitrary units (AU).
Time frame: Baseline and Day 7
Plan to share: No — The individual participant data (IPD) will not be shared due to the small sample size and the risk of re-identification, especially in a critically ill ICU population. The study was not designed with data sharing infrastructure in place.
No publications or documents are linked to this record.
Ran from Nov 2024 to primary completion in Feb 2025, 3 months.
Of 169 non-industry interventional studies with no phase under Muscular Atrophy, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 38. This study's 3 months is below that.
Counting every sponsor, half of 175 studies reached it within 21 months; a quarter within 9 and three quarters within 37.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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Shin Kong Wu Ho-Su Memorial Hospital