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Enrolling by invitationNCT06984666Updated May 22, 2025

Facial Aesthetic Analysis Model Based on Clinical Cohort Phenotype to Explore 45° Facial Profile.

An interventional study of language in Malocclusion, Angle Class II and Malocclusion, Angle Class III, sponsored by Linyu Xu. Enrolling by invitation at 1 site in China. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-22.

Sponsored by Linyu Xu · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Primary completion was expected by Jul 2026, 3 months ago, but the record still lists the study as enrolling by invitation.
  • Registered 7 months after the study started (first participant enrolled Oct 2024, registered May 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
80
Allocation
Non-randomized
Ages
18 Years to 50 Years
Sex
All
01

Study summary

Facial aesthetics has always been a complex and subjective concept. The overall facial harmony, along with lip protrusion, which is often a focus for orthodontists, requires evaluation from multiple perspectives. The viewing angle also influences the assessment of facial aesthetics, particularly the judgment of lip protrusion. This study aims to explore the differences in facial fixation patterns and aesthetic evaluations among different populations at specific viewing angles by using digital models to simulate various perspectives.

Read the detailed description

In the analysis of facial aesthetics, the 45° profile has a unique advantage in evaluating lip protrusion, zygomatic fullness, and contour curve. Compared to the frontal view, this angle provides a more three-dimensional and deeper perspective. In a previous study, the research group found that the shape of the midface area at 45° influences the evaluation of lip protrusion. In this study, a digital model was used to simulate the protrusion of different midface areas in order to explore the differences in facial fixation patterns and aesthetic evaluations among various individuals at 45°. Based on data from individuals who showed significant improvement in frontal and profile beauty before and after clinical treatment, the study added an evaluation of beauty and lip position from the 45° profile. This aims to provide a reference for the subsequent establishment of a 45° profile analysis.

02

Conditions studied

  • Malocclusion, Angle Class II
  • Malocclusion, Angle Class III

Keywords

  • Midface
  • Eye tracking
  • Aesthetic evaluation
  • Perception
  • morphology
03

In context

Malocclusion, Angle Class II

124 studies on the registry are indexed under Malocclusion, Angle Class II; 19 are open to participants now.

This study's planned enrollment of 80 is above the median of 34 across 115 interventional studies indexed under Malocclusion, Angle Class II.

Browse Malocclusion, Angle Class II studies →

Lead sponsor

This is the only study on the registry with Linyu Xu as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Orthodontist inclusion criteria: ① With dental doctor qualification certificate; ② At least 2 years of professional training in orthodontics.

Inclusion criteria for orthodontic patients: ① Receiving orthodontic treatment for more than 1 year; ② Volunteer to participate in the study; ③ Native language is Chinese, can understand the prompt language and normal communication.

General adult inclusion criteria: ① have not experienced orthodontic treatment or have no need for orthodontic treatment; ② Do not engage in stomatology industry, have not studied stomatology specialty; ③ Native language is Chinese, can understand the prompt language and normal communication.

Exclusion criteria

Exclusion Criteria:

① have visual impairment (such as color blindness, high myopia); ②Have psychological problems (such as autism, schizophrenia); ③ Recent use of alcohol, or long-term fatigue, anxiety; Current use of any medication that may affect cognitive ability; ⑤ Use mascara, contact lenses or small frame height glasses

05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
80 participants (estimated)

Study arms

  • No intervention
    Free browsing

    This phase of the experiment serves as baseline data without language intervention.

  • Experimental
    Language cue

    In this phase of the experiment, participants are given language cues to intervene in their eye movement.

    Behavioral: language

Interventions

  • Behaviorallanguage

    Language cues are used to provide participants with psychological suggestions in order to achieve the goal of shifting their focus in gaze patterns.

06

What researchers measure

Primary outcomes

  1. Total fixation duration of area of interest

    The facial images used as stimulus materials are divided into several regions, with the fixation duration in each area of interest serving as the primary measurement. Changes in fixation duration represent a shift in the focus of attention.

    Time frame: The duration of the experiment for each participant does not exceed 10 minutes. A random selection of 10 participants will immediately undergo a repeat experiment after the first round to verify the reliability of the participants.

Secondary outcomes

  1. Eye movement track

    The specific patterns of attention shift will be further observed through the changes in eye-tracking trajectories.

    Time frame: The duration of the experiment for each participant does not exceed 10 minutes.A random selection of 10 participants will immediately undergo a repeat experiment after the first round to verify the reliability of the participants.

07

Study locations

1 site
08

References and documents

Individual participant data

Plan to share: No — There are concerns about excessive patient privacy intrusion, and some patients are unwilling to provide all the requested information, such as unmasked facial data and other sensitive details.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 22, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06984666
Lead sponsor
Linyu Xu
Collaborators
Stomatological Hospital Affiliated with Fujian Medical University
Responsible party
Linyu Xu (Director of the Department of Orthodontics at the Stomatological Hospital Affiliated with Fujian Medical University, Stomatological Hospital Affiliated with Fujian Medical University) — Sponsor-investigator
First posted
May 22, 2025
Start date
Oct 1, 2024
Primary completion
Jul 31, 2026 (estimated)
Completion
Jul 31, 2027 (estimated)
Last update
May 22, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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