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RecruitingNCT07466641Updated May 11, 2026

LLLLT vs Piezocision in Accelerating Orthodontic Canine Retraction

An interventional study of Low Level Laser Therapy and Piezocision in Malocclusion, Angle Class II, Division 1, Bimaxillary Protrusion and Class I Malocclusion, sponsored by Hesham Nabil Ali Al-Qamhawy. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 25 Years. Per ClinicalTrials.gov, last updated 2026-05-11.

Sponsored by Hesham Nabil Ali Al-Qamhawy · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Apr 2026; still recruiting 7 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
21
Allocation
Randomized
Ages
18 Years to 25 Years
Sex
All
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Study summary

This comparative controlled clinical study aims to evaluate and compare the effectiveness of piezocision and low-level laser therapy (LLLT) as adjunctive interventions to accelerate orthodontic canine retraction. Participants will be randomly assigned to one of three groups: piezocision, LLLT, or a control group (no adjunctive procedure). The study will assess the impact of these interventions on the rate of tooth movement, the type of tooth movement, and patient experience.

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Conditions studied

  • Malocclusion, Angle Class II, Division 1
  • Bimaxillary Protrusion
  • Class I Malocclusion

Keywords

  • canine retraction
  • Low-level laser therapy
  • laser
  • piezocision
  • piezosurgery
  • orthodontic canine retraction
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In context

Malocclusion, Angle Class II

124 studies on the registry are indexed under Malocclusion, Angle Class II; 19 are open to participants now.

This study's planned enrollment of 21 is below the median of 34 across 115 interventional studies indexed under Malocclusion, Angle Class II.

Browse Malocclusion, Angle Class II studies →

Lead sponsor

This is the only study on the registry with Hesham Nabil Ali Al-Qamhawy as lead sponsor.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 25 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age range 18-25 years.
  • Patients with crowding or protrusion requiring at least bilateral maxillary first premolar extraction followed by symmetrical canine retraction.
  • Full set of permanent dentition (third molar not considered).
  • Patients with good oral hygiene.

Exclusion criteria

Exclusion Criteria:

  • Previous orthodontic treatment.
  • Patients taking medications or suffering from systemic conditions that can affect orthodontic tooth movement.
  • Active periodontal diseases and/or untreated carious lesions.
  • Congenital orofacial deformities.

Discontinuation criteria:

  • Multiple missing appointments.
  • Poor oral hygiene.
  • Multiple broken appliances to the extent that interferes with obtaining the treatment objectives.
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
21 participants (estimated)

Study arms

  • Experimental
    Low-level laser therapy group

    Procedure: Low Level Laser Therapy

  • Experimental
    Piezocision group

    Procedure: Piezocision

  • No intervention
    Control group

Interventions

  • ProcedureLow Level Laser Therapy

    On both right and left sides, LLLT will be performed at the beginning of canine retraction, after 3, 7, 14 days, and then every 14 days for a total four-month period.

    Also known as: LLLT

  • ProcedurePiezocision

    On both right and left sides, a minimally invasive flapless piezocision procedure will be performed each month from the beginning of the canine retraction for a total four-month period.

    Also known as: Piezosurgery

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What researchers measure

Primary outcomes

  1. Rate of canine retraction

    The rate of distal movement of the maxillary canine measured in millimeters per month (mm/month).

    Time frame: Four months from the beginning of maxillary canine retraction.

Secondary outcomes

  1. Maxillary canine rotation and tipping.

    Measured in degrees

    Time frame: Four months from the beginning of maxillary canine retraction.

  2. Maxillary first molar mesial movement

    Maxillary first molar mesial movement (measured in mm)

    Time frame: Four months from the beginning of maxillary canine retraction.

  3. Maxillary first molar rotatiob

    (measured in degrees).

    Time frame: Four months from the beginning of maxillary canine retraction.

  4. Patient-Reported Pain Intensity

    Pain intensity will be measured using a 10-centimeter Visual Analogue Scale (VAS). The scale ranges from 0 to 10, where 0 represents "no pain" and 10 represents "the worst possible pain" . Therefore, higher scores indicate a worse outcome (greater pain intensity).

    Time frame: Four months from the beginning of maxillary canine retraction.

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Study locations

1 of 1 sites recruiting
  • Outpatient Clinics of the Department of Orthodontics, Faculty of Dental Medicine, Boys, Cairo, Al-Azhar University.
    Cairo, Cairo Governorate, Egypt
    Recruiting
08

References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Apr 2026 (actual). Primary completion is estimated for Feb 2027, 10 months after the start.

Of 86 non-industry interventional studies with no phase under Malocclusion, Angle Class II, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 22. This study's planned 10 months is below that.

Counting every sponsor, half of 86 studies reached it within 15 months; a quarter within 11 and three quarters within 22.

How these figures are worked out, and which studies are left out of them.

Registered
Mar 3, 2026
First posted
Mar 12, 2026
StartActual
Apr 1, 2026
Primary completionEst.
Feb 2027
CompletionEst.
Jun 2027
Last update
May 11, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on May 11, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07466641
Lead sponsor
Hesham Nabil Ali Al-Qamhawy
Collaborators
Al-Azhar University
Responsible party
Hesham Nabil Ali Al-Qamhawy (Principal Investigator, Al-Azhar University) — Sponsor-investigator
First posted
Mar 12, 2026
Start date
Apr 1, 2026
Primary completion
Feb 2027 (estimated)
Completion
Jun 2027 (estimated)
Last update
May 11, 2026

Study contacts

Hesham N Al-Qamhawy
Contact
heshamnabil96@gmail.com
00201099767929
Farouk A Hussein, Professor
study chair · Professor in Orthodontics; Faculty of Dental Medicine, Boys, Cairo; Al-Azhar University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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