An observational study in Hypertension, Resistant to Conventional Therapy, sponsored by University of Campinas, Brazil. Completed at 1 site in Brazil. Open to participants aged 30 Years to 60 Years. Per ClinicalTrials.gov, last updated 2013-04-16.
Sponsored by University of Campinas, Brazil · Observational
The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.
All patients were submitted to office blood pressure measurement, Ambulatory blood pressure monitoring and 24-hour Holter monitoring.
Baseline blood samples for the measurement of glycemia (mg/dL), total cholesterol (mg/dL), LDL cholesterol (mg/dL), triglycerides (mg/dL), creatinine (mg/dL), serum uric acid, serum sodium, serum potassium, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were collected at 08:00 after overnight fasting.
6,689 studies on the registry are indexed under Hypertension; 964 are open to participants now.
This study's enrollment of 44 is below the median of 210 across 1,358 observational studies indexed under Hypertension.
Browse Hypertension studies →University of Campinas, Brazil is the lead sponsor of 166 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Forty-four resistant hypertension subjects, regularly followed up at the cardiovascular clinical pharmacology out-patients' clinic, and who complied with pharmacological prescription for hypertension, were recruited to participate in this transversal and observational study.
Exclusion Criteria:
The current definition of resistant hypertension (RH) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications and those whose BP is controlled when using four or more antihypertensive medications
evaluation of the autonomic function in resistant hypertensive patients
The autonomic nervous system can be assessed by the heart rate variability. Variations in heart rate variability are normally observed in association with diurnal rhythms and blood pressure changes. The heart rate variability parameters are different in many studies, although the consensus is that lower values of the indices of vagal as well as high indices of sympathetic functions are associated prospectively with death and disability. In humans, the disturbances of the circadian rhythms of heart rate variability and blood pressure have been intensively studied, mainly due to the increased cardiovascular death reported during the morning hours
Time frame: 10 months
This study is completed, as verified in Feb 2012. You cannot join it, but the record below documents what was studied.
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University of Campinas, Brazil