Heart Septal Defects, Atrial clinical trials
The registry lists 84 studies for Heart Septal Defects, Atrial across more than 10 countries. 21 are recruiting or about to start. 45 of them are mainly about Heart Septal Defects, Atrial (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13. Counting its narrower condition Foramen Ovale, Patent too: 197 studies, 60 open.
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Who runs them
Lifetech Scientific (Shenzhen) Co., Ltd. (6) · Abbott Medical Devices (4) · W.L.Gore & Associates (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Carag AG (3) · University Health Network, Toronto (2) · Universitaire Ziekenhuizen KU Leuven (2) · Duke University (2)
What is being tested here
Drugs under test in Heart Septal Defects, Atrial studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexmedetomidine | 1 | 1 | 3 |
| Thiamine | 0 | 0 | 1 |
| Citrulline | 0 | 0 | 1 |
| Fluorescein | 0 | 0 | 1 |
| Clopidogrel | 0 | 0 | 1 |
| Ketofol | 0 | 0 | 1 |
| Bosentan | 0 | 1 | 1 |
| Articaine hydrochloride | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Dec 2026A Multicenter Study on the Normal Reference Range and Clinical Significance of the Right Atrioventricular Coupling Index Assessed by Artificial Intelligence-Based Three-Dimensional Echocardiography · First Hospital of China Medical University
- Dec 2026Efficacy of Three Dimensional Transesophageal Echocardiography for Percutaneous Device Closure in Atrial Septal Defect · Asan Medical Center
- Dec 2026Precision TOF-Guided Sugammadex Versus Spontaneous Recovery for Early Extubation in Minimally Invasive Pediatric Cardiac Surgery · Dr. Nguyen Thi Thu Hang
- Dec 2026Cerebral Microembolization Associated With PFO Closure · China National Center for Cardiovascular Diseases
- Mar 2027Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD · atHeart Medical
- Apr 2027From Prehabilitation to Rehabilitation (Prehab2Rehab): Digitally Supported Short-Term Prehabilitation Prior to Cardiac Surgery · Ludwig Boltzmann Institute for Digital Health and Prevention
- Jun 2027Study on the Safety and Effectiveness of a Biodegradable Patent Foramen Ovale Occluder System · Shanghai Lingsi Medical Technology Co., Ltd.
- Jul 2027A Multicenter Randomized Controlled Trial of Echocardiography-Guided Atrial Septal Defect Closure Performed in a Mobile Surgical Unit · China National Center for Cardiovascular Diseases
- Oct 2027A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted by PannaWire · Chinese Academy of Medical Sciences, Fuwai Hospital
Who these studies take
Of the 9 Heart Septal Defects, Atrial studies recruiting now, 4 (44%) set no upper age limit and 3 (33%) stop at 75 or younger. 5 (56%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (56%) | 5 (56%) |
| 18 | 8 (89%) | 8 (89%) |
| 30 | 7 (78%) | 7 (78%) |
| 40 | 7 (78%) | 7 (78%) |
| 50 | 7 (78%) | 7 (78%) |
| 65 | 7 (78%) | 7 (78%) |
| 75 | 6 (67%) | 6 (67%) |
| 85 | 4 (44%) | 4 (44%) |
Across all 84 studies, recruiting or not: 32% stop at 75 or younger and 27% at 65; 52% take children; 0% are for women only and 2% for men only; 6% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Heart Septal Defects, Atrial studies take
Of 19 interventional studies with no phase under Heart Septal Defects, Atrial, half reached primary completion within 24 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 24 mo13–56 · 19 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 84. Browse all 84 → or search them.
- Abbott Structural Heart Device RegistryRecruitingNCT0659046710 countries
- Hummingbird ICE StudyNot yet recruitingNCT075522721 country
- Utility of the Perclose ProGlide™ Suture-Mediated Closure Device After Cardiologic Procedures Via the Femoral Vein Approach (Eight-Clover)Enrolling by invitationNCT07827287Not applicable1 country
- Precision TOF-Guided Sugammadex Versus Spontaneous Recovery for Early Extubation in Minimally Invasive Pediatric Cardiac SurgeryRecruitingNCT077980111 country
- From Prehabilitation to Rehabilitation (Prehab2Rehab): Digitally Supported Short-Term Prehabilitation Prior to Cardiac SurgeryNot yet recruitingNCT07716761Not applicable1 country
- Safety and Efficacy of the AbsnowTM II Absorbable Atrial Septal Defect Closure System for Atrial Septal Defect Closure TherapyNot yet recruitingNCT07529028Not applicable
- Pulmonary Embolism and Right-to-Left ShuntsRecruitingNCT075198761 country
- A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted by PannaWireNot yet recruitingNCT07054541Phase 41 country
- Study on the Safety and Effectiveness of a Biodegradable Patent Foramen Ovale Occluder SystemNot yet recruitingNCT07300358Not applicable
- A Multicenter Study on the Normal Reference Range and Clinical Significance of the Right Atrioventricular Coupling Index Assessed by Artificial Intelligence-Based Three-Dimensional EchocardiographyNot yet recruitingNCT072928961 country
- A Multicenter Randomized Controlled Trial of Echocardiography-Guided Atrial Septal Defect Closure Performed in a Mobile Surgical UnitNot yet recruitingNCT07273227Phase 41 country
- Beta-blockers for Prevention of Supraventricular Arrhythmia Following PFO ClosureNot yet recruitingNCT07123506Not applicable1 country
- Cerebral Microembolization Associated With PFO ClosureRecruitingNCT063472761 country
- Cera™ ASD Occluder Post-Market Clinical Follow-Up StudyRecruitingNCT068496351 country
- Efficacy of Three Dimensional Transesophageal Echocardiography for Percutaneous Device Closure in Atrial Septal DefectRecruitingNCT02097758Not applicable1 country
- Lifetech AcuMark™ Sizing Balloon Post-Market Clinical Follow-up StudyRecruitingNCT067001741 country
- Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal DefectRecruitingNCT06631534Phase 41 country
- Cardiac Interventional ICE Imaging TrialNot yet recruitingNCT06344494Not applicable1 country
- Evaluation of the Effectiveness and Safety of Vibro-acoustic Pulmonary Therapy (VAPT) in Complex Therapy for Acute Respiratory Failure of Mixed Type I-II Stages in Comparison With Percussion Massage in Cardiac Surgical Patients in the Early Postoperative PeriodRecruitingNCT063204831 country
- AWARE Registry: Wearable ECG in Structural Heart InterventionsNot yet recruitingNCT062367761 country
- Canadian Adult Congenital Heart Disease Intervention RegistryNot yet recruitingNCT042885961 country
- Philips Intracardiac Echocardiography (ICE) Clinical RegistryCompletedNCT049501921 country
- Double Transseptal Guide Sheath to Prevent Dock Drop During SAPIEN M3 Transcatheter Mitral Valve ReplacementCompletedNCT078781951 country
- Lifetech CeraFlex™ ASD Closure System Post-Market Clinical Follow-UpActive, not recruitingNCT058877003 countries
- Comparison of Dynamic Compliance and Airway Resistance in Pressure-Controlled Versus Volume-Controlled Ventilation in Children Undergoing Corrective Heart SurgeryCompletedNCT07754591Not applicable1 country
- Improving Care for Children With Congenital Heart Disease.CompletedNCT04667455Not applicable1 country
- The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart DiseaseCompletedNCT06298344Early Phase 11 country
- Safety and Efficacy Study of Transcatheter Closure of Ostium Secundum ASDsCompletedNCT02985684Not applicable1 country
- Trevisio Post-Approval StudyCompletedNCT044335207 countries
- Safety and Efficacy Study of Absnow Absorbable ASD Closure System For Treating ASD PatientsCompletedNCT03601039Not applicable1 country
- General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric PatientsCompletedNCT06431178Not applicable1 country
- Feasibility Study on the VERAFEYE SystemCompletedNCT05931835Not applicable1 country
- Regional Anesthesia Following Pediatric Cardiac SurgeryCompletedNCT05688670Phase 41 country
- Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASDActive, not recruitingNCT04591392Not applicable4 countries
- Novel Modified Technique for Transcatheter Closure of Secundum Atrial Septal Defect: A Single Center ExperienceCompletedNCT06655935Not applicable1 country
- Radiation-Free Heart Catheterization Using MRIActive, not recruitingNCT02739087Not applicable1 country
- Improvement In Left Ventricular Diameter After Closure Of ASD With Fenestrated Patch: A Cross-sectional StudyCompletedNCT061396791 country
- Magnetic Resonance Imaging of Atrial Septal DefectsCompletedNCT004984461 country
- Comparison of Devices for Atrial Septal Defects Closure: A Pilot StudyStatus unknownNCT04291898Not applicable1 country
- Iatrogenic Atrial Septal Defect Study (iASD)WithdrawnNCT04395027Phase 31 country
- Non-Invasive Shunt Quantification in Interatrial CommunicationTerminatedNCT03437148Not applicable1 country
- Holter and ECG Changes After Transcatheter Closure Of ASD In ChildrenStatus unknownNCT05540769Not applicable1 country
- Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised ProtocolCompletedNCT01120964Phase 1/21 country
- Post Market Registry of the CBSOStatus unknownNCT041055951 country
- The Puncturable Atrial Septal Defect Occluder Trial (the PASSER Trial)Status unknownNCT05371366Not applicable1 country
- MitraClip® and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect ClosureStatus unknownNCT03024268Not applicable1 country
- Atrial Septal Defect - Exercise Capacity and Pulmonary HypertensionCompletedNCT035654711 country
- Safety and Efficacy of the GORE® Septal Occluder to Treat Ostium Secundum Atrial Septal DefectsCompletedNCT01711983Not applicable1 country
- Occlutech Septal Occluder (Figulla Flex II) StudyCompletedNCT04488120Not applicable
- Utilization of Confocal Microscopy During Cardiac SurgeryCompletedNCT03189134Phase 11 country