Gender Dysphoria clinical trials
The registry lists 85 studies for Gender Dysphoria across more than 10 countries. 38 are recruiting or about to start. 70 of them are mainly about Gender Dysphoria (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-29.
Get an email when these change. Save the Gender Dysphoria studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Central Hospital, Nancy, France (7) · University Hospital, Ghent (6) · Medical University of Vienna (5) · University Ghent (3) · University of Colorado, Denver (3) · University of California, San Francisco (3) · Amsterdam UMC, location VUmc (3) · Universitätsklinikum Hamburg-Eppendorf (3)
What is being tested here
Drugs under test in Gender Dysphoria studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Mar 2027Can 3D Modeling Enhance Patient Understanding, Education, and Surgical Outcomes in Gender Affirming Peritoneal Vaginoplasty? · University of Chicago
- Mar 2027Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat Content · Medical University of Vienna
- Jun 2027Gender Affirming Vaginoplasty With Tubularized Augmented Peritoneal Cap (TAPCap) Utilizing Fish Skin Xenograft (Kerecis™) · University Hospitals Cleveland Medical Center
- Aug 2027Cardiomodulatory Effects of Gender-Affirming Hormone Therapy · University Hospital, Akershus
- Sep 2027ZEPHYR: A Study Evaluating Surgical Outcome After Implantation of the Zephyr ZSI 475 FTM Inflatable Penile Implant in the Neophallus After Female-to-male Sex Reassignment Surgery · University Hospital, Ghent
- Oct 2027Effects of Cross-sex Hormone Treatment on Cardiac Function, Myocardial and Hepatic Fat Content · Medical University of Vienna
Who these studies take
Of the 31 Gender Dysphoria studies recruiting now, 15 (48%) set no upper age limit and 10 (32%) stop at 75 or younger. 7 (23%) take children under 18. 7 (23%) are for women only and 3 (10%) for men only; 11 (35%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (6%) | 3 (10%) |
| 18 | 26 (84%) | 21 (68%) |
| 30 | 25 (81%) | 20 (65%) |
| 40 | 25 (81%) | 20 (65%) |
| 50 | 23 (74%) | 18 (58%) |
| 65 | 22 (71%) | 16 (52%) |
| 75 | 20 (65%) | 14 (45%) |
| 85 | 20 (65%) | 14 (45%) |
Across all 85 studies, recruiting or not: 42% stop at 75 or younger and 39% at 65; 28% take children; 19% are for women only and 16% for men only; 45% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 85. Browse all 85 → or search them.
- QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)Not yet recruitingNCT07661823Not applicable1 country
- Comparative Study of Gender Identity Disorder Versus ControlRecruitingNCT049351641 country
- China Gender-affirming Hormone Therapy StudyRecruitingNCT053187551 country
- GLOW: Gender-Affirming Care and Mental Health: A Longitudinal Study On Quality of Life, Work Life, and Healthcare OutcomesRecruitingNCT074805901 country
- Metoidioplasty and Phalloplasty Surgery Decision MakingEnrolling by invitationNCT06565663Not applicable1 country
- Evaluation of the Effectiveness of Hormonal Treatment in Adolescents Suffering From Gender DysphoriaRecruitingNCT06351501Phase 31 country
- Swiss ProspectivE Cohort of TRAnsgender and Gender Diverse Individuals - The SPECTRA StudyRecruitingNCT067740531 country
- Brain Health in Transgender AdultsRecruitingNCT076247471 country
- Evaluation of the Variation in Quality of Life During Medical Transition for Transgender People.Not yet recruitingNCT052731121 country
- Can 3D Modeling Enhance Patient Understanding, Education, and Surgical Outcomes in Gender Affirming Peritoneal Vaginoplasty?Not yet recruitingNCT074125091 country
- The Effect of Gender-affirmative Measures on Breast Perception in Trans MenRecruitingNCT072526871 country
- Cardiomodulatory Effects of Gender-Affirming Hormone TherapyEnrolling by invitationNCT071287711 country
- Gender Affirming Vaginoplasty With Tubularized Augmented Peritoneal Cap (TAPCap) Utilizing Fish Skin Xenograft (Kerecis™)RecruitingNCT072861231 country
- Polyethylene-glycol Assisted Nerve Repair in PhalloplastyEnrolling by invitationNCT05897086Phase 2/31 country
- Effects of Cross-sex Hormone Treatment on Cardiac Function, Myocardial and Hepatic Fat ContentRecruitingNCT062456811 country
- Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat ContentRecruitingNCT062916751 country
- Cardiovascular Health of Transgender Individuals During the Gender-affirming PathwayRecruitingNCT071879471 country
- Development of Effective, Opioid Sparing Techniques for Peri-operative Pain Management of Transgender Patients Undergoing Gender Affirming SurgeriesRecruitingNCT04979338Phase 31 country
- The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty PopulationRecruitingNCT062472671 country
- Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning YouthRecruitingNCT045965921 country
- Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing HysterectomyRecruitingNCT06969326Phase 31 country
- The Copenhagen Gender Identity CohortRecruitingNCT069539081 country
- Sexual Functioning After Erection Prosthesis Placement in Post Phalloplasty Transgender PersonsRecruitingNCT066397761 country
- Erectile Aid Use in Post-phalloplasty and Post-metoidioplasty Transgender PatientsRecruitingNCT066397631 country
- Prospective Observational Study on SEBBIN Silicone Gel-filled Testicular ImplantsRecruitingNCT050978201 country
- Optimizing Individual Health Care for Young People With Gender IncongruenceRecruitingNCT065731771 country
- Epithesis Versus Prosthesis in Post-phalloplasty Transgender Patients.RecruitingNCT05883553Not applicable2 countries
- The Effect of Tucking on Semen Quality of Adult Trans WomenRecruitingNCT065309921 country
- Effect of Nitropaste in Chest Masculinizing SurgeryRecruitingNCT06428669Phase 41 country
- Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and ChondrolaryngoplastyRecruitingNCT06439290Not applicable1 country
- Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm ExtractionRecruitingNCT064001991 country
- ZEPHYR: A Study Evaluating Surgical Outcome After Implantation of the Zephyr ZSI 475 FTM Inflatable Penile Implant in the Neophallus After Female-to-male Sex Reassignment SurgeryRecruitingNCT040646711 country
- Patient Reported Outcome on Genital Sensitivity and Sexual Function After Genital Gender Affirming SurgeryRecruitingNCT04993469Not applicable1 country
- Gynaecological Gender-affirming SurgeriesRecruitingNCT060987811 country
- Peritoneum Vaginoplasty; Implementation According to IDEAL FrameworkRecruitingNCT05925361Not applicable1 country
- Early Mental Response - The EMRE StudyRecruitingNCT05649605Not applicable1 country
- Transgender In TransitionRecruitingNCT040282192 countries
- Sex Hormone Overdose and Misuse in Chinese Transgender and Gender Non-conforming PopulationNot yet recruitingNCT055830581 country
- Evaluating the Efficacy of Force Modulating Tissue Bridge Device in Preventing Hypertrophic Scars Following Gender-Affirming MastectomyTerminatedNCT07147166Not applicable1 country
- Testicular Tissue Cryopreservation in the Setting of Gender-Affirming TherapyActive, not recruitingNCT058299281 country
- Ovarian Tissue Cryopreservation in the Setting of Gender-affirming TherapyActive, not recruitingNCT058636761 country
- Developmental Correlates and Hormone Therapy Effects in Gender DysphoriaWithdrawnNCT04309760Not applicable
- Skeletal Health and Bone Marrow Composition Among YouthTerminatedNCT04203381Not applicable1 country
- Counseling Among Gender Diverse Adolescents Who Use Depot MedroxyprogesteroneCompletedNCT05726903Phase 41 country
- Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender VeteransCompletedNCT066154011 country
- Comparing the Effects of Sublingual Estradiol Treatment Versus Oral Estradiol With Cyproterone Acetate (CPA) Treatment on The Coagulation System in Transgender Women: A Prospective, Controlled Cohort StudyCompletedNCT07145281Not applicable1 country
- Effects of Gender-affirming Hormone Therapy on Transgender PeopleCompletedNCT060225621 country
- Investigation of the Perceptual and Acoustic Voice in Trans ManCompletedNCT051660831 country
- Trans Care: An Online Intervention to Reduce Symptoms of Gender DysphoriaCompletedNCT05903911Not applicable1 country
- Acoustic and Perceptual Effects of Intonation Training in Gender Diverse PeopleCompletedNCT05204732Not applicable1 country