An observational study in Gender Dysphoria, sponsored by University Hospital, Lille. Not yet recruiting at 13 sites in France. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-05-20.
Sponsored by University Hospital, Lille · Observational
Among 11 studies in Gender Dysphoria with a site in France — 3 open to participants now, 3 under way, 1 of them phase 3. Gender Dysphoria · France.
Among the 11 studies in Gender Dysphoria with a site in France, this one has the largest planned enrollment of the 10 observational ones that give a count, is the only one that started in 2027, is one of 10 observational ones, and was the 9th registered.
85 studies on the registry are indexed under Gender Dysphoria; 38 are open to participants now.
This study's planned enrollment of 400 is above the median of 100 across 52 observational studies indexed under Gender Dysphoria.
Browse Gender Dysphoria studies →3 of the 11 studies in Gender Dysphoria with a site in France are open now, in 1 country. Each count lists the studies.
Of the 31 Gender Dysphoria studies recruiting now, 15 (48%) set no upper age limit and 10 (32%) stop at 75 or younger; 7 take children under 18; 11 take healthy volunteers.
This study: 18 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →11 studies; the count open now beside each. This study's row is marked.
First in 2019; this study’s year is marked. 1 started in 2027.
Median enrollment 60 across the 1 interventional studies, 110 across the 10 observational. Of the 4 that completed or were terminated, 0 (0%) have results posted.
None of the 11 has an industry lead sponsor. The 6 most frequent:
University Hospital, Lille is the lead sponsor of 631 studies on the registry; 142 are open to participants now.
University Hospital, Lille has 1 study filed under Gender Dysphoria — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 11 studies in Gender Dysphoria with a site in France, from their registry updates:
Nothing recorded among them since 2026-09-25.
Transgender people can benefit from psychological, psychiatric, endocrinological support, sexual reassignment surgery, sexology support and dermatological care. The value of transitional care courses is scientifically recognized. Currently, the modalities of decision and realization of the care paths are heterogeneous on the territory, little standardized, and are the subject of debates between representatives of users and medical teams.
The french national report of IGAS from 2011 warns of the need to argue and legitimize care practices through more numerous, more exhaustive scientific studies, presenting a better level of evidence
Since 2011, no prospective study has been carried out on the national and international level, making it possible to assess the relevance of the planned care modalities. This research project, conducted over five consecutive years at the first contact of a transgender people with a care device, aims to correlate a variation in the quality of life of people with the characteristics of the care methods provided. This is a first proposal to assess care practices for transgender people. The results of this study would first allow us to infer the care modalities most suited to the needs of people. Secondly, secondary hypotheses could support new experimental protocols.
This research is a prospective multicenter cohort study with a 3-year and 5-year follow-up of transgender people in medical transition.
Main aim:
Evaluate the evolution of the quality of life during five years in transgender people who benefit from transition support cares.
Secondary objectives:
Secondary objective n°1 :
Identify the different factors that influence the evolution of quality of life evaluated over three years in transgender people who benefit from transition support cares.
Secondary objective n°2 :
Evaluate the evolution of the satisfaction of the shared medical decision for transgender people in medical transition.
Secondary objective n°3 :
Evaluate the evolution of the satisfaction of body image for transgender people in medical transition.
Secondary objective n°4 :
Evaluate the evolution of psychiatric comorbidities for transgender people in medical transition.
Secondary objective n°5 :
Evaluate the benefits and limits in long term (five years) on the quality of life, the satisfaction of the shared medical decision, the satisfaction of body image and the evolution of psychiatric comorbidities.
transgender people in medical transition
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Quality of life scores
Scores on the WHOQOL BREF (World Health Organisation Quality Of Life) scale
Time frame: 3 years
Social factors (age, gender, profession, knowledge of care system)
Answers given by the patient during interview
Time frame: Baseline and 6 months, 12 months, 18 months, 24 months, 30 months, 3 years and 5 years
Satisfaction of the shared medical decision
Scores on the CDIS (Clinical Decision-making Involvement and Satisfaction) clinical decision making involvement and satisfaction score 15 questions scored 1-5 (totally disagree, strongly disagree, neither agree nor disagree, strongly agree, totally agree)
Time frame: 6 months, 12 months, 18 months, 24 months, 30 months, 3 years and 5 years
Satisfaction of body image
Score on the BIS (Body Image Scale), total score ranges from 0 to 30, A higher score means a higher level of body image disturbance
Time frame: 6 months, 12 months, 18 months, 24 months, 30 months, 3 years and 5 years
General psychopathology
French version of Mini International Neuropsychiatric Interview (DSM)
Time frame: 6 months, 12 months, 18 months, 24 months, 30 months, 3 years and 5 years
Anxiety and depression
Anxiety and depression scores on the HAD scale (Hospital Anxiety and Depression scale), a score upper 8 means is considered as a risk of an anxiety or depressive disorder
Time frame: 6 months, 12 months, 18 months, 24 months, 30 months, 3 years and 5 years
Quality of life scores
Scores on the WHOQOL BREF (World Health Organisation Quality Of Life) scale
Time frame: 6 months, 12 months, 18 months, 24 months, 30 months, 5 years
Start is estimated for Jan 2027; primary completion for Apr 2030, 39 months later.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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