Essential Tremor clinical trials
The registry lists 272 studies for Essential Tremor across more than 10 countries. 75 are recruiting or about to start. 186 of them are mainly about Essential Tremor (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
Get an email when these change. Save the Essential Tremor studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
InSightec (13) · National Institute of Neurological Disorders and Stroke (NINDS) (12) · University of Florida (11) · Mayo Clinic (9) · Cala Health, Inc. (5) · University Hospital, Bordeaux (5) · University of Texas Southwestern Medical Center (5) · Sage Therapeutics (4)
What is being tested here
Drugs under test in Essential Tremor studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Z944 | 1 | 1 | 3 |
| Apomorphine | 1 | 0 | 1 |
| BP-14979 | 1 | 0 | 1 |
| 1-Octanol | 0 | 0 | 4 |
| SAGE-324 | 0 | 1 | 3 |
| Octanoic acid | 0 | 0 | 3 |
| Suvecaltamide | 0 | 0 | 2 |
| Pregabalin | 0 | 0 | 2 |
| Propranolol | 0 | 0 | 2 |
| Zonisamide | 0 | 0 | 2 |
Drug classes tested here Calcium channel blockers 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study · Mayo Clinic
- Dec 2026Proof of Concept Study on BP1.4979 Effect on Essential Tremor · Bioprojet
- Dec 2026Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control · Jorge Gonzalez-Martinez
- Dec 2026Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor · University of California, Los Angeles
- Feb 2027Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease · CND Life Sciences
- Feb 2027Cortical-Basal Ganglia Speech Networks · Massachusetts General Hospital
- Mar 2027Effects of Stimulation Patterns of Deep Brain Stimulation · Duke University
- Mar 2027Ultrasound Neuromodulation in Essential Tremor · University of California, San Francisco
- Mar 2027Non-Invasive Neuromodulation for Essential Tremor: Long-Term Safety and Effectiveness Study · Ruijin Hospital
- Apr 2027Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor · University Hospital, Geneva
Who these studies take
Of the 61 Essential Tremor studies recruiting now, 32 (52%) set no upper age limit and 5 (8%) stop at 75 or younger. 8 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 7 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (13%) | 8 (13%) |
| 18 | 46 (75%) | 46 (75%) |
| 30 | 58 (95%) | 58 (95%) |
| 40 | 58 (95%) | 58 (95%) |
| 50 | 61 (100%) | 61 (100%) |
| 65 | 61 (100%) | 61 (100%) |
| 75 | 59 (97%) | 59 (97%) |
| 85 | 50 (82%) | 50 (82%) |
Across all 272 studies, recruiting or not: 12% stop at 75 or younger and 1% at 65; 10% take children; <1% are for women only and <1% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Essential Tremor studies take
Of 20 phase 2 interventional studies under Essential Tremor, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 17 mo10–29 · 20 studies | — | — |
| Interventional, no phase | 45 mo19–93 · 95 studies | — | 52 mo26–… · 77 studies |
| Observational | 58 mo25–… · 26 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Effects of Microelectrode-based Brain Stimulation in HumansNov 3, 2026NCT07820189
Stopped1
- Tapping Test and the Archimedean Spiral for the Differential Diagnosis of Tremor. Machine Learning ApproachTerminatedOct 28, 2026NCT06378619
Newly registered1
- The Encora X1™ in a Real World Observational StudyNov 2, 2026NCT07911488
Studies
Recruiting first, then most recently updated. Showing 50 of 272. Browse all 272 → or search them.
- Deep Brain Stimulation Surgery for Movement DisordersRecruitingNCT01581580Not applicable1 country
- Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's DiseaseRecruitingNCT074284471 country
- The Encora X1™ in a Real World Observational StudyRecruitingNCT079114881 country
- Effects of Microelectrode-based Brain Stimulation in HumansRecruitingNCT07820189Not applicable1 country
- Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Essential TremorRecruitingNCT07673107Phase 22 countries
- Phenotype/Genotype Correlations in Movement DisordersRecruitingNCT000188891 country
- Stereotactic Radiosurgery in the Treatment of Essential TremorRecruitingNCT06821906Phase 21 country
- Coordinated Reset Deep Brain Stimulation for Essential TremorRecruitingNCT05897775Phase 11 country
- Deep Brain Stimulation Therapy in Movement DisordersRecruitingNCT02119611Not applicable1 country
- Radiofrequency (RF) Ablation Prospective Outcomes Study for Central Nervous System - RAPID for CNSRecruitingNCT065536252 countries
- Boston Scientific Registry of Deep Brain Stimulation for Treatment of Essential Tremor (ET)RecruitingNCT040324709 countries
- Intraoperative Microelectrode Recordings Using MAVEN Compared to Standard Recording ApparatusesRecruitingNCT078686141 country
- Deep Brain Stimulation (DBS) Retrospective Outcomes StudyRecruitingNCT036646096 countries
- Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)RecruitingNCT06087276Phase 31 country
- A Study of Wearable Device in Essential Tremor PatientsEnrolling by invitationNCT05976074Not applicable1 country
- Motor Network PhysiologyRecruitingNCT04957095Not applicable1 country
- Magnetoencephalography (MEG) Pilot StudyRecruitingNCT07446192Not applicable1 country
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic TractRecruitingNCT04758624Not applicable1 country
- Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor FunctionRecruitingNCT07056348Not applicable1 country
- Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle ControlRecruitingNCT07056361Not applicable1 country
- Stereotactic Radiosurgery for Essential Tremor and Parkinsonian TremorRecruitingNCT017341221 country
- Neurofeedback Using Implanted Deep Brain Stimulation ElectrodesRecruitingNCT05101161Not applicable1 country
- 3-D Tractography FUS Ablation for Essential TremorRecruitingNCT06331052Not applicable1 country
- EMBRACE Tremor BiFUSRecruitingNCT06974916Not applicable7 countries
- Physiological Brain Atlas DevelopmentRecruitingNCT005750811 country
- Non-Invasive Neuromodulation for Essential Tremor: Long-Term Safety and Effectiveness StudyRecruitingNCT07774598Not applicable1 country
- LIFUS For Neurological DisordersRecruitingNCT07417280Not applicable1 country
- Image-Guided DBS ProgrammingNot yet recruitingNCT07433699Not applicable1 country
- Circadian Adaptive DBS in Essential TremorRecruitingNCT06635811Not applicable1 country
- Human Cognition During Surgery: Stimulation-based and Cholinergic ModulationNot yet recruitingNCT07721272Early Phase 11 country
- Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory TremorRecruitingNCT07049003Phase 11 country
- Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential TremorRecruitingNCT07599592Early Phase 11 country
- Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential TremorRecruitingNCT062936381 country
- Closed-loop TMS for TremorRecruitingNCT07574164Not applicable1 country
- Attention and Eye Movement in Parkinson's DiseaseRecruitingNCT06899022Not applicable1 country
- Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential TremorNot yet recruitingNCT07531238Not applicable1 country
- Effects of Stimulation Patterns of Deep Brain StimulationEnrolling by invitationNCT02553525Not applicable1 country
- Cerebellar Research in Ultrasound StimulationNot yet recruitingNCT07508696Not applicable1 country
- Cortical-Basal Ganglia Speech NetworksRecruitingNCT04286308Not applicable1 country
- Motor and Non-Motor Effects of Low-Intensity Focused Ultrasound (LIFU) as a Neuromodulation Tool in Essential TremorNot yet recruitingNCT07484152Phase 1/2
- Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator RecipientsRecruitingNCT07455760Not applicable1 country
- Ultrasound Neuromodulation in Essential TremorRecruitingNCT06610877Not applicable1 country
- ET Stigma Response to Tremor SuppressionRecruitingNCT074307611 country
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential TremorRecruitingNCT04212780Not applicable1 country
- Algorithms for Programming DBS Systems for ETRecruitingNCT03984643Not applicable1 country
- Dual-Site Transcranial Magnetic Stimulation of the Supplementary Motor Area and Cerebellum for the Treatment of Essential Tremor.RecruitingNCT07344194Phase 1/21 country
- Abbott DBS Post-Market Study of Outcomes for Indications Over TimeRecruitingNCT040718479 countries
- Neuromodulation Strategies for Treatment-Resistant Essential Tremor Using Chronos™ DBSNot yet recruitingNCT07302867Not applicable1 country
- Proof of Concept Study on BP1.4979 Effect on Essential TremorRecruitingNCT07074002Phase 21 country
- Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated DystoniaRecruitingNCT05317390Not applicable1 country