An interventional study of Continuous and Continuous + High Frequency Cycling in Essential Tremor, sponsored by University of British Columbia. Not yet recruiting at 1 site in Canada. Open to participants aged 19 Years to 85 Years. Per ClinicalTrials.gov, last updated 2025-12-24.
Sponsored by University of British Columbia · Not applicable, Interventional, and Treatment
The goal of this observational study is to learn whether a new way of programming Deep Brain Stimulation (DBS) can improve and maintain tremor control in adults with essential tremor (ET) who stopped responding to standard DBS therapy.
The main questions it aims to answer are:
Researchers will compare six different stimulation settings to see if any of them can improve tremor symptoms when standard DBS programming no longer works.
Participants will:
This study will include 5 participants with essential tremor who previously lost benefit quickly after receiving standard VIM-DBS treatment.
272 studies on the registry are indexed under Essential Tremor; 75 are open to participants now.
This study's planned enrollment of 5 is below the median of 25 across 189 interventional studies indexed under Essential Tremor.
Browse Essential Tremor studies →University of British Columbia is the lead sponsor of 1,339 studies on the registry; 259 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
All participants will test six different experimental DBS stimulation programs in the clinic using Chronos™ software. After trying all six programs, each participant will be randomly assigned to one of the six stimulation patterns to use at home for the study period. There is no control or placebo group; all participants receive an active DBS programming intervention.
Other: Continuous · Other: Continuous + High Frequency Cycling · Other: High Frequency · Other: Microburst · Other: Scheduling · Other: Cycling
DBS setting: 185 Hz, 60 µs pulse width, optimized amplitude
DBS setting: Alternates 30s at 185 Hz and 30s at 1000 Hz
DBS setting: 1000 Hz continuous, 60 µs, optimized amplitude
DBS setting: 900 Hz intraburst, 80 Hz interburst, 6 pulses per packet
DBS setting: Two or three effective programs on alternating schedules
DBS setting: 30s on / 5s off cycle without ramp, subthreshold stimulation
The Fahn-Tolosa-Marín Tremor Rating Scale (FTM-TRS)
Time frame: 3-Month post programming
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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