Ependymoma clinical trials
The registry lists 224 studies for Ependymoma across more than 10 countries. 35 are recruiting or about to start. 42 of them are mainly about Ependymoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
National Cancer Institute (NCI) (34) · M.D. Anderson Cancer Center (8) · Wake Forest University Health Sciences (7) · Children's Oncology Group (7) · City of Hope Medical Center (7) · Case Comprehensive Cancer Center (6) · St. Jude Children's Research Hospital (6) · Duke University (5)
What is being tested here
Drugs under test in Ependymoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| AZD 6244 | 2 | 0 | 4 |
| Lutetium Lu 177 dotatate | 2 | 0 | 2 |
| Temozolomide | 1 | 1 | 20 |
| Etoposide | 1 | 2 | 6 |
| Irinotecan | 1 | 0 | 4 |
| Cyclophosphamide | 1 | 1 | 4 |
| Olaparib | 1 | 0 | 3 |
| ONC206 | 1 | 0 | 2 |
| G 207 | 1 | 0 | 2 |
| Oncolytic HSV-1 G207 | 1 | 0 | 2 |
Drug classes tested here Alkylating agents 2 open · Immune checkpoint inhibitors 2 open · Tyrosine kinase inhibitors (TKIs) 1 open · PARP inhibitors 1 open · Antimetabolites 10
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Jan 2027A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 · Dana-Farber Cancer Institute
- Jan 2027Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma · City of Hope Medical Center
- Mar 2027Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms · Jazz Pharmaceuticals
- May 2027Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors · Seattle Children's Hospital
- May 2027ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors · Sabine Mueller, MD, PhD
- Jun 2027Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas · Cellectar Biosciences, Inc.
- Jul 2027Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors · Memorial Sloan Kettering Cancer Center
- Jul 2027Methionine PET/CT Studies In Patients With Cancer · St. Jude Children's Research Hospital
- Oct 2027Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-Being · University of Colorado, Denver
Who these studies take
Of the 24 Ependymoma studies recruiting now, 7 (29%) set no upper age limit and 15 (63%) stop at 75 or younger. 18 (75%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 17 (71%) | 17 (71%) |
| 18 | 24 (100%) | 24 (100%) |
| 30 | 14 (58%) | 14 (58%) |
| 40 | 10 (42%) | 10 (42%) |
| 50 | 10 (42%) | 10 (42%) |
| 65 | 10 (42%) | 10 (42%) |
| 75 | 10 (42%) | 10 (42%) |
| 85 | 8 (33%) | 8 (33%) |
Across all 224 studies, recruiting or not: 52% stop at 75 or younger and 49% at 65; 59% take children; 0% are for women only and <1% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ependymoma studies take
Of 42 phase 1 interventional studies under Ependymoma, half reached primary completion within 62 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 62 mo39–92 · 42 studies | — | 65 mo39–92 · 36 studies |
| Phase 2 | 67 mo52–108 · 35 studies | — | 66 mo47–108 · 34 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 224. Browse all 224 → or search them.
- LET Optimized IMPT in Treating Pediatric Patients With EpendymomaRecruitingNCT03750513Phase 11 country
- PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN AmplificationsRecruitingNCT06161519Phase 1/21 country
- Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-BeingRecruitingNCT07628647Not applicable1 country
- Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain CancerRecruitingNCT05106296Phase 11 country
- Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young AdultsNot yet recruitingNCT07891286Phase 21 country
- Selumetinib for NF2-Related SchwannomatosisNot yet recruitingNCT07707947Phase 21 country
- Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)RecruitingNCT04374305Phase 21 country
- Natural History Study of Patients With Neurofibromatosis Type 2RecruitingNCT005983511 country
- Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma, ATRT and Rare CNS TumorsRecruitingNCT01356290Phase 28 countries
- Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncologyRecruitingNCT046484621 country
- Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)RecruitingNCT06193759Phase 11 country
- Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of EpendymomaNot yet recruitingNCT07848568Phase 1/2
- Pharmacoscopy for Patients With Refractory Primary Brain TumorsRecruitingNCT06804655Phase 21 country
- Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade GliomaRecruitingNCT07061626Phase 11 country
- HSV G207 in Children With Recurrent or Refractory Cerebellar Brain TumorsRecruitingNCT03911388Phase 11 country
- B7-H3.CD28Z.CART in CNS NeoplasmsRecruitingNCT07390539Phase 11 country
- Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and EpendymomaRecruitingNCT05057702Not applicable1 country
- AI-Assisted MRI Molecular Subtyping in Pediatric Brain TumorsNot yet recruitingNCT07703605
- Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2)Not yet recruitingNCT07713745Phase 21 country
- Lutathera for Treatment of Recurrent or Progressive High-Grade CNS TumorsRecruitingNCT05278208Phase 1/21 country
- ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS TumorsRecruitingNCT04732065Phase 13 countries
- Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).RecruitingNCT06607692Phase 1/21 country
- Intratumoral DNX-2401 for High Grade Pediatric Brain TumorsRecruitingNCT07424092Phase 22 countries
- Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric TumorsNot yet recruitingNCT07589361
- A Safety and Efficacy Study of Combined Fianlimab + Cemiplimab in Children and Young Adults With Recurrent or Progressive High-Grade Glioma or Posterior Fossa-A EpendymomaNot yet recruitingNCT07567469Phase 1/2
- Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System TumorsRecruitingNCT04185038Phase 11 country
- MRE Evaluation for Spinal Cord Tumor Surgery: Stiffness and Adhesion AssessmentRecruitingNCT05957679Not applicable1 country
- Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO ClassificationRecruitingNCT0525960512 countries
- International HIT-MED Registry (I-HIT-MED)RecruitingNCT024173241 country
- Systemic Biomarkers to Predict Radiation-Induced Neurocognitive DeclineRecruitingNCT067794871 country
- The Use of 5-ALA in Paediatric Patients With High Grade Brain TumoursNot yet recruitingNCT06678867Phase 21 country
- Integrated Analysis of Therapy Response and Resistence in Embryonal Tumors and GliomasNot yet recruitingNCT06323408
- In Vitro Models From Pediatric Brain TumorsNot yet recruitingNCT064996361 country
- Axitinib and Oral Metronomic Etoposide for Pediatric Children and AYA Refractory/Relapsing Medulloblastoma and EpendymomaNot yet recruitingNCT06485908Phase 1/2
- Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in ChinaRecruitingNCT056720431 country
- Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System NeoplasmsActive, not recruitingNCT04541082Phase 11 country
- Rare CNS Tumors Outcomes &RiskCompletedNCT032519891 country
- Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System TumorsCompletedNCT014452881 country
- Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPGActive, not recruitingNCT04049669Phase 21 country
- PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and EpendymomaSuspendedNCT06639607Phase 1/21 country
- Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)Active, not recruitingNCT03213652Phase 24 countries
- Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS CancersTerminatedNCT03173950Phase 21 country
- Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2CompletedNCT01082926Phase 11 country
- Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)Active, not recruitingNCT03210714Phase 22 countries
- Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment TrialActive, not recruitingNCT04284774Phase 22 countries
- Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment TrialActive, not recruitingNCT04320888Phase 23 countries
- Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant GliomaCompletedNCT00730613Phase 1
- Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and SarcomasActive, not recruitingNCT03478462Phase 13 countries
- Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade GliomaActive, not recruitingNCT07031765Phase 11 country
- Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)Active, not recruitingNCT03698994Phase 22 countries