digital ulcers clinical trials
The registry lists 29 studies for digital ulcers across more than 10 countries. 7 are recruiting or about to start. 7 of them are mainly about digital ulcers (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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· Sites: 4 added, including Seoul and Busan
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Who runs them
Actelion (6) · Pfizer (2) · Charite University, Berlin, Germany (2) · Elpen Pharmaceutical Co. Inc. (2) · Primus Pharmaceuticals (1) · UMC Utrecht (1) · Pharmosa Biopharm Inc. (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1)
What is being tested here
Drugs under test in digital ulcers studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Diosmin | 1 | 0 | 1 |
| Bosentan | 0 | 2 | 3 |
| Macitentan | 0 | 2 | 2 |
| rimabotulinumtoxinB | 0 | 0 | 1 |
| Riociguat | 0 | 0 | 1 |
| Tadalafil | 0 | 1 | 1 |
| Treprostinil | 0 | 0 | 1 |
| Iloprost | 0 | 0 | 1 |
| Homo sapiens whole | 0 | 0 | 1 |
Drug classes tested here Endothelin receptor antagonists 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Nov 2026Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic Sclerosis · UMC Utrecht
- Jul 2027Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis · Primus Pharmaceuticals
- Sep 2027Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic Sclerosis · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Who these studies take
Of the 4 digital ulcers studies recruiting now, 3 (75%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 4 (100%) | 4 (100%) |
| 30 | 4 (100%) | 4 (100%) |
| 40 | 4 (100%) | 4 (100%) |
| 50 | 4 (100%) | 4 (100%) |
| 65 | 4 (100%) | 4 (100%) |
| 75 | 4 (100%) | 4 (100%) |
| 85 | 4 (100%) | 4 (100%) |
Across all 29 studies, recruiting or not: 10% stop at 75 or younger and 3% at 65; 3% take children; 0% are for women only and 0% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 29 of 29. search them.
- Study of Diosmin for the Treatment of Digital Ulcers in Systemic SclerosisRecruitingNCT06256575Not applicable1 country
- Efficacy and Safety Study of L608 in Patients With Systemic Sclerosis-associated Digital UlcersNot yet recruitingNCT07925619Phase 2
- Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic SclerosisRecruitingNCT06954597Phase 22 countries
- Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic SclerosisNot yet recruitingNCT07717060Not applicable
- Hand Disability In Systemic Sclerosis - Digital UlcersEnrolling by invitationNCT066584701 country
- Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic SclerosisRecruitingNCT03211793Phase 1/21 country
- Effectiveness of Bosentan Therapy in Patients With Systemic scleRosis and Progressive Digital ulcEr Disease.RecruitingNCT051682151 country
- Bosentan in Systemic SclerosisCompletedNCT01395732Phase 41 country
- Bosentan in Digital UlcersCompletedNCT00319696Phase 3
- Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis PatientsTerminatedNCT01474122Phase 3
- Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With SclerodermaCompletedNCT00077584Phase 3
- Open-Label Study of Oral Treprostinil in Digital UlcersTerminatedNCT00848107Phase 23 countries
- Effectiveness of the EmoLED Medical Device in the Healing of Digital Ulcers in Patients With Scleroderma.TerminatedNCT05181644Not applicable1 country
- Co-designing Digital Ulcers Opportunities With Patients and CliniciansStatus unknownNCT05785403
- Rheopheresis for Raynaud's and Digital Ulcers in Systemic SclerosisStatus unknownNCT05204784Not applicable1 country
- Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort StudyTerminatedNCT026421461 country
- Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic SclerosisCompletedNCT03007004Phase 21 country
- Riociguat in Scleroderma Associated Digital UlcersCompletedNCT02915835Phase 21 country
- Bosentan Treatment of Digital Ulcers Related to Systemic SclerosisCompletedNCT027980551 country
- ADMSCs for the Treatment of Systemic SclerosisCompletedNCT02975960Not applicable1 country
- Autologous Adipose Tissue in the Treatment of Systemic Sclerosis Digital UlcersStatus unknownNCT03406988Not applicable1 country
- CSL Behring Sclero XIIIStatus unknownNCT02551042Phase 21 country
- Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis PatientsCompletedNCT01474109Phase 318 countries
- Digital UlcerationCompletedNCT0137709015 countries
- Safety and Efficacy Study of MRE0094 to Treat Chronic, Neuropathic, Diabetic Foot UlcersCompletedNCT00312364Phase 21 country
- Safety and Efficacy Study of MRE0094 to Treat Large, Single or Multiple, Chronic, Neuropathic, Diabetic Foot UlcersTerminatedNCT00318214Phase 21 country
- A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in SclerodermaCompletedNCT01117298Phase 31 country
- Sildenafil for Treatment of Digital Ulcers in Patients With Systemic SclerosisCompletedNCT00624273Phase 21 country
- Effect of Different Iloprost Doses on Symptoms in Systemic SclerosisTerminatedNCT00622687Phase 21 country