Demyelinating Diseases clinical trials
The registry lists 103 studies for Demyelinating Diseases across more than 10 countries. 25 are recruiting or about to start. 11 of them are mainly about Demyelinating Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04. Counting its 14 narrower conditions too, such as Multiple Sclerosis: 4,165 studies, 857 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
National Institute of Neurological Disorders and Stroke (NINDS) (6) · Alexion Pharmaceuticals, Inc. (4) · Acorda Therapeutics (4) · Xuanwu Hospital, Beijing (3) · Novartis Pharmaceuticals (3) · University of Texas at Austin (2) · Holy Name Medical Center, Inc. (2) · SwanBio Therapeutics, Inc. (2)
What is being tested here
Drugs under test in Demyelinating Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- May 2027Non-inferiority Study of Rituximab Compared to Ocrelizumab in Relapsing MS · Phase 3 · Amsterdam UMC, location VUmc
- Dec 2026Assessment of Carpal Tunnel Syndrome by Shearwave Elastography · Mayo Clinic
- Mar 2027The Aim of the Present Study is to Determine Outcome Predictors in Children Who Were Diagnosed as Acute Disseminated Encephalomyelitis (ADEM). · Assiut University
- Apr 2027VIsual Pathways Model in Neuro-inflammatory Disorders · University Hospital, Lille
- Jun 2027Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study · University of Washington
- Jun 2027A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS) · Sundance Biosciences, Inc.
- Jul 2027Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating Diseases · Xuanwu Hospital, Beijing
- Jul 2027Effectiveness of Personalized Alternating Current Stimulation for Treating Emotional Disorders in CNS Demyelination Patients · Xuanwu Hospital, Beijing
- Jul 2027Core Stability, Functional Capacity, Balance, Strength, and Fatigue in Pediatric Demyelinating Diseases · Istanbul University - Cerrahpasa
- Jul 2027Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases · Xuanwu Hospital, Beijing
Who these studies take
Of the 16 Demyelinating Diseases studies recruiting now, 5 (31%) set no upper age limit and 8 (50%) stop at 75 or younger. 1 (6%) take children under 18. 1 (6%) are for women only and 0 (0%) for men only; 2 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (6%) | 1 (6%) |
| 18 | 15 (94%) | 14 (88%) |
| 30 | 15 (94%) | 14 (88%) |
| 40 | 15 (94%) | 14 (88%) |
| 50 | 16 (100%) | 15 (94%) |
| 65 | 15 (94%) | 14 (88%) |
| 75 | 8 (50%) | 7 (44%) |
| 85 | 6 (38%) | 5 (31%) |
Across all 103 studies, recruiting or not: 60% stop at 75 or younger and 52% at 65; 21% take children; 2% are for women only and 3% for men only; 17% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 103. Browse all 103 → or search them.
- A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)RecruitingNCT07840326Phase 21 country
- Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis SubjectsRecruitingNCT04699747Phase 11 country
- Use of a Portable Pupillometer to Detect Optic Nerve Impairment in Patients With Suspected Multiple SclerosisNot yet recruitingNCT07837050Not applicable
- Exploring the Utility of [18F]3F4AP for Demyelination ImagingRecruitingNCT06999434Phase 11 country
- Core Stability, Functional Capacity, Balance, Strength, and Fatigue in Pediatric Demyelinating DiseasesNot yet recruitingNCT076547381 country
- Quality of Life in Women With X-linked AdrenoleukodystrophyRecruitingNCT046757491 country
- Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating DiseasesRecruitingNCT07029386Not applicable1 country
- Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility StudyRecruitingNCT07759115Not applicable1 country
- Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory StudyNot yet recruitingNCT077235991 country
- The Italian Multiple Sclerosis and Related Disorders RegisterEnrolling by invitationNCT076368761 country
- MRI-Based Lesion Differentiation in Older Patients With Multiple SclerosisRecruitingNCT074440471 country
- The Aim of the Present Study is to Determine Outcome Predictors in Children Who Were Diagnosed as Acute Disseminated Encephalomyelitis (ADEM).Not yet recruitingNCT07540182
- Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair TherapyNot yet recruitingNCT06065670Phase 1/21 country
- Assessment of Carpal Tunnel Syndrome by Shearwave ElastographyEnrolling by invitationNCT04804293Not applicable1 country
- Institutional Registry of Rare DiseasesRecruitingNCT065737231 country
- Natalizumab for the Treatment of People With Inflammatory Demyelination Suggestive of Multiple Sclerosis, or Definite Multiple Sclerosis, at First Presentation (AttackMS)RecruitingNCT05418010Phase 21 country
- VIsual Pathways Model in Neuro-inflammatory DisordersRecruitingNCT054879891 country
- Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating DiseasesRecruitingNCT06942611Not applicable1 country
- Effectiveness of Personalized Alternating Current Stimulation for Treating Emotional Disorders in CNS Demyelination PatientsRecruitingNCT06933537Not applicable1 country
- Digital Diagnostics and Intervention Services for Parkinson's DiseaseNot yet recruitingNCT06534177
- Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating DiseasesRecruitingNCT065416261 country
- Comparison of Diagnostic Performances of 3D FLAIR, DIR and PSIR Sequences in Optic NeuritisRecruitingNCT064942281 country
- Non-inferiority Study of Rituximab Compared to Ocrelizumab in Relapsing MSRecruitingNCT05834855Phase 31 country
- Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic NerveRecruitingNCT0560595117 countries
- Demyelinating Diseases of the Central Nervous System Registry for Patients With Traditional Chinese Medicine (DATE-TCM)Not yet recruitingNCT05415579
- Gene Transfer Clinical Trial for Infantile and Late Infantile Krabbe Disease Treated Previously With HSCTActive, not recruitingNCT05739643Phase 1/21 country
- Aerobic Exercise for Remyelination in Multiple SclerosisCompletedNCT04539002Not applicable1 country
- A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)TerminatedNCT05394064Phase 1/22 countries
- Cognition and MRI Markers in MS Patients With Aubagio® TreatmentCompletedNCT03768648Not applicable1 country
- Visual (Path)Ways in Multiple Sclerosis - Part IICompletedNCT06776224Not applicable1 country
- Analysis of the Epidemiology, Clinical Presentation and Therapy as Well as Therapy-associated Risk of Demyelination Syndrome in Patients With Profound Hyponatremia in the Emergency DepartmentCompletedNCT067817101 country
- The Natural History of Mucolipidosis Type IVTerminatedNCT010677421 country
- Contrast-enhanced 3D T1-weighted Gradient-echo Versus Spin-echo 3 Tesla MR Sequences in the Detection of Active Multiple Sclerosis LesionsCompletedNCT03268239Not applicable1 country
- Imaging Study of the White Matter Lesions in Children With Metachromatic LeucodystrophyCompletedNCT01325025Not applicable1 country
- Study of Disease Progression in Adults With Inherited Forms of Spastic ParaplegiaTerminatedNCT050088743 countries
- An Efficacy and Safety Study of Ravulizumab in Adult Participants With NMOSDCompletedNCT04201262Phase 313 countries
- ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research ProgramActive, not recruitingNCT04782466Not applicable2 countries
- Use of Stromal Vascular Fraction in Multiple SclerosisSuspendedNCT03461419Not applicable2 countries
- PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPFCompletedNCT06683612Phase 11 country
- Metformin Treatment in Progressive Multiple SclerosisCompletedNCT05349474Early Phase 11 country
- Cell-Based Therapy for White Matter Repair in Periventricular LeukomalaciaWithdrawnNCT06985303Early Phase 1
- Telerehabilitation of Multidomain Cognitive Impairment in Multiple SclerosisTerminatedNCT05611047Not applicable1 country
- IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Progressive Multiple SclerosisSuspendedNCT06677710Phase 11 country
- Epidural Stimulation in Multiple SclerosisCompletedNCT06019611Not applicable1 country
- Ukulele Playing to Improve Cognition in People with Multiple Sclerosis: a Feasibility StudyCompletedNCT05792176Not applicable1 country
- Study Evaluating the Safety of Myeliviz Myelin-Targeting PET AgentWithdrawnNCT04333290Early Phase 11 country
- Upper Extremity Function in Multiple Sclerosis Patients With Advanced Disability Treated With OcrevusCompletedNCT035629751 country
- A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum DisorderTerminatedNCT04155424Phase 2/37 countries
- Electronic Monitoring of Disease Activity in Patients With Chronic Inflammatory Demyelinating PolyneuropathyCompletedNCT057238481 country
- Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple SclerosisTerminatedNCT03283826Phase 1/23 countries