Demyelinating Diseases: all 103 studies

Page 1 of 2. Open to participants first (25), then studies with results posted, then the rest; newest registration first within each.

• A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)RecruitingNCT07840326Phase 2
• Use of a Portable Pupillometer to Detect Optic Nerve Impairment in Patients With Suspected Multiple SclerosisNot yet recruitingNCT07837050Not applicable
• Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility StudyRecruitingNCT07759115Not applicable
• Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory StudyNot yet recruitingNCT07723599
• Core Stability, Functional Capacity, Balance, Strength, and Fatigue in Pediatric Demyelinating DiseasesNot yet recruitingNCT07654738
• The Italian Multiple Sclerosis and Related Disorders RegisterEnrolling by invitationNCT07636876
• The Aim of the Present Study is to Determine Outcome Predictors in Children Who Were Diagnosed as Acute Disseminated Encephalomyelitis (ADEM).Not yet recruitingNCT07540182
• MRI-Based Lesion Differentiation in Older Patients With Multiple SclerosisRecruitingNCT07444047
• Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating DiseasesRecruitingNCT07029386Not applicable
• Exploring the Utility of [18F]3F4AP for Demyelination ImagingRecruitingNCT06999434Phase 1
• Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating DiseasesRecruitingNCT06942611Not applicable
• Effectiveness of Personalized Alternating Current Stimulation for Treating Emotional Disorders in CNS Demyelination PatientsRecruitingNCT06933537Not applicable
• Institutional Registry of Rare DiseasesRecruitingNCT06573723
• Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating DiseasesRecruitingNCT06541626
• Digital Diagnostics and Intervention Services for Parkinson's DiseaseNot yet recruitingNCT06534177
• Comparison of Diagnostic Performances of 3D FLAIR, DIR and PSIR Sequences in Optic NeuritisRecruitingNCT06494228
• Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair TherapyNot yet recruitingNCT06065670Phase 1/2
• Non-inferiority Study of Rituximab Compared to Ocrelizumab in Relapsing MSRecruitingNCT05834855Phase 3
• Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic NerveRecruitingNCT05605951
• VIsual Pathways Model in Neuro-inflammatory DisordersRecruitingNCT05487989
• Natalizumab for the Treatment of People With Inflammatory Demyelination Suggestive of Multiple Sclerosis, or Definite Multiple Sclerosis, at First Presentation (AttackMS)RecruitingNCT05418010Phase 2
• Demyelinating Diseases of the Central Nervous System Registry for Patients With Traditional Chinese Medicine (DATE-TCM)Not yet recruitingNCT05415579
• Assessment of Carpal Tunnel Syndrome by Shearwave ElastographyEnrolling by invitationNCT04804293Not applicable
• Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis SubjectsRecruitingNCT04699747Phase 1
• Quality of Life in Women With X-linked AdrenoleukodystrophyRecruitingNCT04675749
• Epidural Stimulation in Multiple SclerosisCompletedNCT06019611Not applicableResults posted
• A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)TerminatedNCT05394064Phase 1/2Results posted
• Aerobic Exercise for Remyelination in Multiple SclerosisCompletedNCT04539002Not applicableResults posted
• An Efficacy and Safety Study of Ravulizumab in Adult Participants With NMOSDCompletedNCT04201262Phase 3Results posted
• A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum DisorderTerminatedNCT04155424Phase 2/3Results posted
• Upper Extremity Function in Multiple Sclerosis Patients With Advanced Disability Treated With OcrevusCompletedNCT03562975Results posted
• A Study of HyQvia and Gammagard Liquid (Kiovig) in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)CompletedNCT02549170Phase 3Results posted
• Long-term, Open-label, Multicenter Study Assessing Long-term Cardiovascular RisksCompletedNCT02232061Phase 4Results posted
• N-MOmentum: A Clinical Research Study of Inebilizumab in Neuromyelitis Optica Spectrum DisordersCompletedNCT02200770Phase 2/3Results posted
• An Open Label Extension Trial of Eculizumab in Relapsing NMO PatientsCompletedNCT02003144Phase 3Results posted
• A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive Participants With NMO (PREVENT Study)TerminatedNCT01892345Phase 3Results posted
• Efficacy and Safety of AIN457 (Secukinumab) in Patients With Relapsing Multiple SclerosisTerminatedNCT01874340Phase 2Results posted
• Retrospective Cohort Study of Rebif® Use in Pediatric Multiple Sclerosis (MS) Subjects (REPLAY)CompletedNCT01207648Results posted
• Safety, Tolerability, Efficacy and Optimal Dose Finding Study of BAF312 in Patients With Relapsing-remitting Multiple SclerosisCompletedNCT00879658Phase 2Results posted
• Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR in Patients With Multiple SclerosisCompletedNCT00654927Phase 3Results posted
• Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR in Patients With Multiple Sclerosis Who Participated in the MS-F204 TrialCompletedNCT00649792Phase 3Results posted
• Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR Tablets in Multiple Sclerosis Patients Who Participated in the MS-F203 TrialCompletedNCT00648908Phase 3Results posted
• Study of Fampridine-SR Tablets in Multiple Sclerosis PatientsCompletedNCT00483652Phase 3Results posted
• Cell-Based Therapy for White Matter Repair in Periventricular LeukomalaciaWithdrawnNCT06985303Early Phase 1
• Analysis of the Epidemiology, Clinical Presentation and Therapy as Well as Therapy-associated Risk of Demyelination Syndrome in Patients With Profound Hyponatremia in the Emergency DepartmentCompletedNCT06781710
• Visual (Path)Ways in Multiple Sclerosis - Part IICompletedNCT06776224Not applicable
• PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPFCompletedNCT06683612Phase 1
• IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Progressive Multiple SclerosisSuspendedNCT06677710Phase 1
• Ukulele Playing to Improve Cognition in People with Multiple Sclerosis: a Feasibility StudyCompletedNCT05792176Not applicable
• Gene Transfer Clinical Trial for Infantile and Late Infantile Krabbe Disease Treated Previously With HSCTActive, not recruitingNCT05739643Phase 1/2
• Electronic Monitoring of Disease Activity in Patients With Chronic Inflammatory Demyelinating PolyneuropathyCompletedNCT05723848
• Telerehabilitation of Multidomain Cognitive Impairment in Multiple SclerosisTerminatedNCT05611047Not applicable
• Effects of Ofatumumab Treatment on Immune Cells and Meningeal Lymphatic Drainage in Patients With Demyelinating DiseasesStatus unknownNCT05414487
• Metformin Treatment in Progressive Multiple SclerosisCompletedNCT05349474Early Phase 1
• Pediatric Patient Experience on a Diagnostic PathStatus unknownNCT05199363Not applicable
• Study of Disease Progression in Adults With Inherited Forms of Spastic ParaplegiaTerminatedNCT05008874
• Neurophysiological Assessment in Patients With Multiple SclerosisStatus unknownNCT04997343Not applicable
• Humoral and T-Cell Responses to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab Treated With Ocrelizumab or NatalizumabCompletedNCT04837651
• ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research ProgramActive, not recruitingNCT04782466Not applicable
• Power Training in Older Multiple Sclerosis PatientsStatus unknownNCT04762342Not applicable
• Exploring the Utility of [18F]3F4AP for Demyelination Imaging in Controls, Neurodegeneration and Traumatic Brian InjuryActive, not recruitingNCT04710550Phase 1
• Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculographyCompletedNCT04705610Not applicable
• Eye Movements Recording Using a Smartphone: Comparison to Standard Video-oculography in Patients With Multiple SclerosisCompletedNCT04702763
• A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple SclerosisCompletedNCT04626921Phase 2/3
• Study Evaluating the Safety of Myeliviz Myelin-Targeting PET AgentWithdrawnNCT04333290Early Phase 1
• Effects of a Weight Based Training Program on MS PatientsStatus unknownNCT04002492Not applicable
• Efficacy and Safety of Nerve Growth Factor or Edaravone on Alcohol-induced Brain InjuryStatus unknownNCT03968042Phase 2
• Cognition and MRI Markers in MS Patients With Aubagio® TreatmentCompletedNCT03768648Not applicable
• BN201 SAD MAD Study in Healthy SubjectsCompletedNCT03630497Phase 1
• Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis PatientsStatus unknownNCT03610139Not applicable
• Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple SclerosisTerminatedNCT03536559Phase 2
• Use of Stromal Vascular Fraction in Multiple SclerosisSuspendedNCT03461419Not applicable
• Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side EffectsStatus unknownNCT03424733Phase 4
• Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple SclerosisTerminatedNCT03283826Phase 1/2
• Contrast-enhanced 3D T1-weighted Gradient-echo Versus Spin-echo 3 Tesla MR Sequences in the Detection of Active Multiple Sclerosis LesionsCompletedNCT03268239Not applicable
• Behavior and Activity Monitoring in MSCompletedNCT03244696Not applicable
• Pharmacological Recruitment of Endogenous Neural Precursors to Promote Pediatric White Matter Repair: Establishing Correlations Between Visual Outcomes, Saccadic Function and MEG Oscillations in Children With Demyelinating Disorders in Comparison to Healthy Control ChildrenCompletedNCT03010826
• Use of Cellular Stromal Vascular Fraction in Multiple Sclerosis,Autoimmune, Inflammatory, Neurologic ConditionsWithdrawnNCT02939859Phase 1
• The French Cohort and Biobank of Devic's Neuromyelitis Optica and Related Neurological Disorders (NMOSD) (NOMADMUS)CompletedNCT02850705
• Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of BIIB033 in Healthy Japanese ParticipantsCompletedNCT02641041Phase 1
• A Pilot Study of Vitamin D in Boys With X-linked AdrenoleukodystrophyCompletedNCT02595489Phase 1
• Autologous Mesenchymal Stromal Cells for Multiple SclerosisCompletedNCT02495766Phase 1/2
• Pilot Trial of Domperidone in Relapsing-Remitting Multiple Sclerosis (RRMS)CompletedNCT02493049Phase 2
• MS Symptom Management StudyCompletedNCT02474940Not applicable
• DTI in Children With Multiple SclerosisStatus unknownNCT02361697Not applicable
• Natural History Study of Children With Metachromatic LeukodystrophyTerminatedNCT01963650
• Optic Neuritis Recovery After Oral or IV CorticosteroidsCompletedNCT01524250Phase 2/3
• Environmental and Genetic Risk Factors for Pediatric Multiple SclerosisCompletedNCT01396343
• Imaging Study of the White Matter Lesions in Children With Metachromatic LeucodystrophyCompletedNCT01325025Not applicable
• Advanced MRI Measures of Repair in Alemtuzumab Treated PatientsCompletedNCT01307332Phase 3
• An Observational Study on the Progression of Clinically Isolated Syndrome to Multiple Sclerosis Over a 2-year PeriodCompletedNCT01112657
• The Natural History of Mucolipidosis Type IVTerminatedNCT01067742
• Autologous Mesenchymal Stem Cells From Adipose Tissue in Patients With Secondary Progressive Multiple SclerosisCompletedNCT01056471Phase 1/2
• A Study of Orally Administered BGC20-0134 (Structured Lipid) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)TerminatedNCT01037907Phase 2
• AT RISK FOR MS - Clinical Conversion of Female Monozygotic Twins Discordant for CIS/MSCompletedNCT00617383
• Immunological Mechanisms of Hematopoietic Stem Cell Transplantation in Multiple SclerosisCompletedNCT00342134Phase 2
• Biomarkers in Multiple SclerosisCompletedNCT00325988
• Oligodendrocyte Progenitor Cell Culture From Human BrainCompletedNCT00283023Phase 1
• Zenapax (Daclizumab) to Treat Relapsing Remitting Multiple SclerosisCompletedNCT00071838Phase 2
• Rituximab to Treat Neuropathy With Anti-MAG AntibodiesCompletedNCT00050245Phase 2

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