Cholangiocarcinoma: all 930 studies

Page 4 of 10. Open to participants first (292), then studies with results posted, then the rest; newest registration first within each.

• MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)CompletedNCT05007106Phase 2Results posted
• Durvalumab and Tremelimumab With Platinum-based Chemotherapy in Intrahepatic Cholangiocarcinoma (ICC)TerminatedNCT04989218Phase 1/2Results posted
• Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract CancerActive, not recruitingNCT04941287Phase 2Results posted
• Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)-China Extension StudyCompletedNCT04924062Phase 3Results posted
• A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid TumorsCompletedNCT04853017Phase 1Results posted
• A Study of HMPL-306 in Advanced Solid Tumors With IDH MutationsTerminatedNCT04762602Phase 1Results posted
• Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT141 in Patients With Unresectable or Metastatic CLDN18.2-positive Gastric, Pancreatic, Ovarian and Biliary Tract TumorsTerminatedNCT04683939Phase 1/2Results posted
• A Home-Based Approach Study to Evaluate the Efficacy and Safety of Alectinib in Locally-Advanced or Metastatic ALK-Positive Solid TumorsTerminatedNCT04644315Phase 2Results posted
• Prospective Evaluation of Biliary Tissue Sampling With ERCPCompletedNCT04572711Results posted
• Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).TerminatedNCT04566133Phase 2Results posted
• Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal CancersActive, not recruitingNCT04430738Phase 2Results posted
• Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid TumorsTerminatedNCT04383210Phase 2Results posted
• Study of Pembrolizumab and Olaparib in Bile Duct CancerCompletedNCT04306367Phase 2Results posted
• Durvalumab and SNDX-6532 Following Chemo or Radio-Embolization for Patients With Intrahepatic CholangiocarcinomaCompletedNCT04301778Phase 2Results posted
• Codman Catheter/Synchromed Pump Hepatic Artery Chemotherapy for Unresectable Colorectal Metastases/Intrahepatic CholangiocarcinomaTerminatedNCT04276090Not applicableResults posted
• mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic CholangiocarcinomaTerminatedNCT04251715Phase 2Results posted
• Infigratinib for the Treatment of Advanced or Metastatic Solid Tumors in Patients With FGFR Gene MutationsCompletedNCT04233567Phase 2Results posted
• Gemcitabine and Cisplatin With or Without CPI-613 as First Line Therapy for Patients With Advanced Unresectable Biliary Tract Cancer (BilT-04)TerminatedNCT04203160Phase 1/2Results posted
• Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the LiverActive, not recruitingNCT04175912Phase 2Results posted
• A Study to Find a Safe and Effective Dose of BI 905711 in Patients With Advanced Gastrointestinal CancerCompletedNCT04137289Phase 1Results posted
• PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct CancerTerminatedNCT04099888Phase 2Results posted
• Futibatinib Versus Gemcitabine-Cisplatin Chemotherapy as First-Line Treatment of Patients With Advanced Cholangiocarcinoma Harboring FGFR2 Gene RearrangementsTerminatedNCT04093362Phase 3Results posted
• Gemcitabine and Cisplatin With Ivosidenib or Pemigatinib for the Treatment of Unresectable or Metastatic CholangiocarcinomaTerminatedNCT04088188Phase 1Results posted
• Trifluridine/Tipiracil and Irinotecan for the Treatment of Advanced Refractory Biliary Tract CancerCompletedNCT04072445Phase 2Results posted
• Gemcitabine Plus Cisplatin With or Without Bintrafusp Alfa (M7824) in Participants With 1L BTCTerminatedNCT04066491Phase 2/3Results posted
• Mesothelin-Targeted Immunotoxin LMB-100 in Combination With Tofacitinib in Persons With Previously Treated Pancreatic Adenocarcinoma, Cholangiocarcinoma and Other Mesothelin Expressing Solid TumorsCompletedNCT04034238Phase 1Results posted
• Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)CompletedNCT04003636Phase 3Results posted
• Testing Olaparib and AZD6738 in IDH1 and IDH2 Mutant TumorsActive, not recruitingNCT03878095Phase 2Results posted
• M7824 Monotherapy in Locally Advanced or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)CompletedNCT03833661Phase 2Results posted
• Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal CancersCompletedNCT03801915Phase 2Results posted
• Phase 3 Study of BGJ398 (Oral Infigratinib) in First Line Cholangiocarcinoma With FGFR2 Gene Fusions/TranslocationsTerminatedNCT03773302Phase 3Results posted
• Trial of IRE in CholangiocarcinomaCompletedNCT03769753Phase 2Results posted
• Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract CancersCompletedNCT03768414Phase 3Results posted
• A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or CholangiocarcinomaCompletedNCT03693807Phase 2Results posted
• A Study of FT-2102 in Patients With Advanced Solid Tumors and Gliomas With an IDH1 MutationCompletedNCT03684811Phase 1/2Results posted
• A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid TumorsCompletedNCT03665285Phase 1/2Results posted
• A Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Chemotherapy in Unresectable or Metastatic CholangiocarcinomaTerminatedNCT03656536Phase 3Results posted
• Personal Resilience Empowerment Program StudyCompletedNCT03644173Not applicableResults posted
• Gemcitabine, Cisplatin, and Nab-Paclitaxel Before Surgery in Patients With High-Risk Liver Bile Duct CancerCompletedNCT03579771Phase 2Results posted
• A Pilot Study to Assess Theragnostically Planned Liver Radiation to Optimize Radiation TherapyCompletedNCT03338062Not applicableResults posted
• TAS-102 in Treating Advanced Biliary Tract CancersCompletedNCT03278106Phase 2Results posted
• Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder AdenocarcinomaTerminatedNCT03267940Phase 1Results posted
• A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic AdenocarcinomaCompletedNCT03250273Phase 2Results posted
• Derazantinib in Subjects With FGFR2 Gene Fusion-, Mutation- or Amplification- Positive Inoperable or Advanced Intrahepatic CholangiocarcinomaCompletedNCT03230318Phase 2Results posted
• Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 MutationsActive, not recruitingNCT03212274Phase 2Results posted
• A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)CompletedNCT03207347Phase 2Results posted
• Atezolizumab With or Without Cobimetinib in Treating Patients With Metastatic Bile Duct Cancer That Cannot Be Removed by Surgery or Gallbladder CancerCompletedNCT03201458Phase 2Results posted
• Pembrolizumab, a Monoclonal Antibody Against PD-1, in Combination With Capecitabine and Oxaliplatin (CAPOX) in People With Advanced Biliary Tract Carcinoma (BTC)CompletedNCT03111732Phase 2Results posted
• A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6CompletedNCT03058289Phase 1/2Results posted
• A Study to Determine Best Tumor Response With Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2 (HER2) Overexpressing Solid TumorsCompletedNCT02999672Phase 2Results posted
• A Trial of Systemic Chemotherapy in Combination With Conventional Transarterial Chemoembolization in Patients With Advanced Intra-Hepatic CholangiocarcinomaTerminatedNCT02994251Phase 2Results posted
• Study of AG-120 in Previously Treated Advanced Cholangiocarcinoma With IDH1 Mutations (ClarIDHy)CompletedNCT02989857Phase 3Results posted
• Evaluating Combination Immunotherapy for Advanced Cholangiocarcinoma With Pembrolizumab and PEG-IntronTerminatedNCT02982720Phase 2Results posted
• Efficacy and Safety of Pemigatinib in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Who Failed Previous Therapy - (FIGHT-202)CompletedNCT02924376Phase 2Results posted
• Sulfur Colloid SPECT/CT in Measuring Liver Function in Patients With Primary or Metastatic Liver Cancer Undergoing Radiation Therapy or SurgeryTerminatedNCT02881554Not applicableResults posted
• A Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)CompletedNCT02821754Phase 2Results posted
• SIRT Followed by CIS-GEM Chemotherapy Versus CIS-GEM Chemotherapy Alone as 1st Line Treatment of Patients With Unresectable Intrahepatic CholangiocarcinomaTerminatedNCT02807181Phase 2/3Results posted
• A Study of LY3039478 in Participants With Advanced or Metastatic Solid TumorsTerminatedNCT02784795Phase 1Results posted
• Copanlisib (BAY 80-6946) in Combination With Gemcitabine and Cisplatin in Advanced CholangiocarcinomaCompletedNCT02631590Phase 2Results posted
• Ramucirumab in Treating Patients With Advanced or Metastatic, Previously Treated Biliary Cancers That Cannot Be Removed by SurgeryCompletedNCT02520141Phase 2Results posted
• RRx-001 in Second Line Treatment of Advanced Cholangiocarcinoma Prior to Readministration of First-Line TherapyTerminatedNCT02452970Phase 2Results posted
• Phase II Trial of Dasatinib in Patients With Isocitrate Dehydrogenase (IDH)-Mutant Advanced Intrahepatic CholangiocarcinomaCompletedNCT02428855Phase 2Results posted
• Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)TerminatedNCT02393248Phase 1/2Results posted
• Gemcitabine Hydrochloride, Cisplatin, and Nab-Paclitaxel in Treating Patients With Advanced or Metastatic Biliary CancersCompletedNCT02392637Phase 2Results posted
• Study of Orally Administered Enasidenib (AG-221) in Adults With Advanced Solid Tumors, Including Glioma, or Angioimmunoblastic T-cell Lymphoma, With an IDH2 MutationCompletedNCT02273739Phase 1/2Results posted
• A Pilot Study of Neoadjuvant Therapy With Gemcitabine and Cisplatin in Patients With Resectable or Unresectable Intrahepatic CholangiocarcinomaTerminatedNCT02256982Not applicableResults posted
• Low-Dose Radiation Therapy to the Whole Liver With Gemcitabine and Cisplatin in IHCTerminatedNCT02254681Phase 2Results posted
• Radiation Therapy vs. Observation Following Gemcitabine and Cisplatin for Inoperable Localized Liver CancerTerminatedNCT02200042Phase 3Results posted
• Phase II Trial of Nab-Paclitaxel and Gemcitabine for First-Line Treatment of Patients With CholangiocarcinomaCompletedNCT02181634Phase 2Results posted
• A Phase II, Single Arm Study of BGJ398 in Patients With Advanced CholangiocarcinomaTerminatedNCT02150967Phase 2Results posted
• Efficacy and Safety Study of PDT Using Photofrin in Unresectable Advanced Perihilar Cholangiocarcinoma (OPUS)TerminatedNCT02082522Phase 3Results posted
• A Phase 2 Trial of Regorafenib as A Single Agent in Advanced and Metastatic Biliary Tract Carcinoma/Cholangiocarcinoma Patients Who Have Failed First-line ChemotherapyCompletedNCT02053376Phase 2Results posted
• A Study of TAS-120 in Patients With Advanced Solid TumorsCompletedNCT02052778Phase 1/2Results posted
• Trametinib or Combination Chemotherapy in Treating Patients With Refractory or Advanced Biliary or Gallbladder Cancer or That Cannot Be Removed by SurgeryCompletedNCT02042443Phase 2Results posted
• Etomidate vs. Midazolam for Sedation During ERCPCompletedNCT02027311Phase 4Results posted
• Cabozantinib (XL-184) Monotherapy for Advanced CholangiocarcinomaCompletedNCT01954745Phase 2Results posted
• Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC)CompletedNCT01862315Phase 2Results posted
• CPI-613 in Treating Patients With Advanced or Metastatic Bile Duct Cancer That Cannot Be Removed By SurgeryCompletedNCT01766219Phase 1/2Results posted
• Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic AlterationsCompletedNCT01752920Phase 1/2Results posted
• The Role of Gadoxetate (Eovist) Enhanced CT in Evaluating CholangiocarcinomaCompletedNCT01673802Early Phase 1Results posted
• Drug-Eluting Bead, Irinotecan Therapy for Unresectable Intrahepatic Cholangiocarcinoma w/Concomitant Gemcitabine and Cisplatin or CarboplatinCompletedNCT01648023Phase 2Results posted
• Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Chemotherapy and Radiation Therapy for Pancreatic CancerCompletedNCT01534637Phase 2Results posted
• Stereotactic Body Radiotherapy for Liver TumorsCompletedNCT01347333Not applicableResults posted
• Endoscopic Bipolar Radiofrequency Probe (ENDOHPB) in the Management of Unresectable Bile Duct and Pancreatic CancerTerminatedNCT01303159Not applicableResults posted
• Yttrium-90 Radioembolization Using Glass Microspheres (TheraSphere) for Patients With Liver MetastasesCompletedNCT01290536Phase 2Results posted
• Effects of Preoperative Immunonutrition in Patients Undergoing PancreaticoduodenectomyCompletedNCT01256034Phase 4Results posted
• Study Of Intrahepatic Arterial Injection of 90-Y Glass Microspheres for CholangiocarcinomaCompletedNCT01253148Not applicableResults posted
• Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary CancersTerminatedNCT01229111Phase 2Results posted
• Phase II SBRT & Chemo for Unresectable Cholangiocarcinoma Followed by Liver TransplantationTerminatedNCT01151761Phase 2Results posted
• Comparison Between Internal and External Preoperative Biliary Drainage in Periampullary CancersCompletedNCT01134276Not applicableResults posted
• Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or CholangiocarcinomaCompletedNCT01093222Phase 2Results posted
• A Study of Gemcitabine, Capecitabine and Bevacizumab to Treat Cancer of the Gall Bladder or Bile DuctsCompletedNCT01007552Phase 2Results posted
• Chemoradiation +Gemcitabine +Continuous 5-FU (Fluorouracil) Followed by High Dose Brachytherapy/Stereotactic Radiation Boost in Locally Advanced Intra/Extrahepatic CholangiocarcinomaTerminatedNCT00983541Phase 2Results posted
• Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast CancerTerminatedNCT00959946Phase 1/2Results posted
• A Study of Combination of Gemcitabine, Oxaliplatin (GEMOX)-Sorafenib in Patients With Advanced Biliary Tract CancerTerminatedNCT00955721Phase 1/2Results posted
• Study of Gemcitabine, Irinotecan and Panitumumab in Patients With Advanced and Metastatic Biliary Tract AdenocarcinomaCompletedNCT00948935Phase 2Results posted
• Gemcitabine and Cisplatin Plus Sorafenib in Patients With Advanced Biliary Tract Carcinomas Naive to Systemic TherapyCompletedNCT00919061Phase 2Results posted
• Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal CancerTerminatedNCT00903396Phase 2Results posted
• Gemcitabine, Oxaliplatin, Tarceva &/or Cisplatin in HCC & Biliary Tree CancersTerminatedNCT00832637Phase 2Results posted
• S0809: Capecitabine, Gemcitabine, and RT in Patients w/Cholangiocarcinoma of the Gallbladder or Bile DuctCompletedNCT00789958Phase 2Results posted

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