Central Nervous System Diseases: all 386 studies

Page 3 of 4. Open to participants first (104), then studies with results posted, then the rest; newest registration first within each.

• CTH120 First-in-Human Study: Single and Multiple Ascending Doses and Potential Food InteractionCompletedNCT06480968Phase 1
• Pilot Study: A Novel Method of Non-Invasive Brain Stimulation (kTMP) to Enhance Motor Function in Chronic Stroke PatientsCompletedNCT06317194Not applicable
• Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD SubjectsTerminatedNCT06304883Phase 3
• An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC DeficiencyActive, not recruitingNCT06255782Phase 3
• Gravity Stent-Retriever System For Reperfusion Of Large Vessel Occlusion Stroke TrialCompletedNCT06249776Not applicable
• A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01TerminatedNCT06247345Phase 1
• A Dose-finding Study to Evaluate mRNA-3210 in Participants With PhenylketonuriaWithdrawnNCT06147856Phase 1/2
• Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's DiseaseTerminatedNCT06079190Phase 2
• A Second Intermediate-Size Expanded Access Protocol (EAP) for Pridopidine in People With Amyotrophic Lateral Sclerosis (Pridopidine EAP 2)No longer availableNCT06069934
• A Study to Evaluate Long-term Safety of Ecopipam Tablets in Children, Adolescents and Adults With Tourette's DisorderActive, not recruitingNCT06021522Phase 3
• Comprehensive Management of High-risk PopuLatIon for Stroke Based on Social NetworkCompletedNCT05963828Not applicable
• Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PDCompletedNCT05819359Phase 2
• Precision Medicine in StrokeCompletedNCT05815836
• A Phase 2 Clinical Study to Explore the Optimal Dosage/Administration of PM012 Tablet in Alzheimer's DiseaseStatus unknownNCT05811000Phase 2/3
• Gene Transfer Clinical Trial for Infantile and Late Infantile Krabbe Disease Treated Previously With HSCTActive, not recruitingNCT05739643Phase 1/2
• Video-call Assisted Assessment of Acute Stroke in Addition to Stroke Severity Scales in a Prehospital SettingCompletedNCT05737420Not applicable
• The Effect of Craniosacral Therapy as Additive Procedure.CompletedNCT05722756
• Multiple-dose Trial to Determine the Clinical Bioequivalence Between Tavapadon Tablets in Participants With Parkinson's DiseaseCompletedNCT05610189Phase 1
• A Study to Evaluate AB-1001 Striatal Administration in Adults With Early Manifest Huntington's DiseaseActive, not recruitingNCT05541627Phase 1/2
• A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese PopulationCompletedNCT05527288Not applicable
• An Open-Label Extension of XPro1595 in Patients With Alzheimer's DiseaseTerminatedNCT05522387Phase 2
• A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)Active, not recruitingNCT05508789Phase 3
• Safety and Pharmacokinetic Study of NPT 2042 Soft-gelatin Capsules Administered Orally to Healthy Adult SubjectsCompletedNCT05503511Phase 1
• Chinese Validation of the Simplified Evaluation of CONsciousness Disorders（SECONDs）CompletedNCT05496985Not applicable
• Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease ParticipantsActive, not recruitingNCT05469360Phase 1
• A Multicenter Study of Ultrafast Pulse Wave Velocity in Obese Chinese Han AdultsStatus unknownNCT05455099
• Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's DiseaseStatus unknownNCT05452655Not applicable
• A Clinical Trial of PRAX-114 in Participants With Essential TremorWithdrawnNCT05387642Phase 2
• Propranolol on Post Stroke Immune Status and InfectionStatus unknownNCT05375240Phase 2
• Clinical Applications of (S)-[18F]FBFP PET/CT in Healthy Volunteers and Patients With Central Nervous System DiseasesStatus unknownNCT05335200Phase 1
• Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of InflammationWithdrawnNCT05321498Phase 2
• Ventriculomegaly and Gait Disturbance in the Senior Population in the Region of VästerbottenCompletedNCT05204745
• A Study to Evaluate Safety and Efficacy of AMZ002 Treatment, Compared With Vigabatrin in Participants With Infantile SpasmsWithdrawnNCT05128344Phase 3
• Pilot Study to Evaluate the Self-Management of Gait, Speech, and Dexterity Symptoms in Parkinson's Disease Using a Smartphone ApplicationStatus unknownNCT05120609Not applicable
• Effect of Meditation and Controls and Subjects With Parkinson's Disease on Brain Activity Measured by fMRI With FDOPAWithdrawnNCT05103618Phase 2
• Diagnosic and Pronostic Values of Kappa and Lambda Free Light Chains in Central Nervous System Inflammatory DiseasesCompletedNCT05088473
• Using Real-world Evidence to Analyze the Clinical Effects and Adverse Events of Butylphthalide in Stroke PatientsCompletedNCT05086874
• Phase 1 ALKS 1140 in Healthy AdultsTerminatedNCT05019105Phase 1
• The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) StudyCompletedNCT05007353Not applicable
• The Personalized Parkinson Project De Novo CohortActive, not recruitingNCT04985539
• Dopaminergic Therapy for Frontotemporal Dementia PatientsCompletedNCT04937452Phase 2
• Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced DyskinesiaSuspendedNCT04912115Phase 2
• Adjunctive Use of Fute (Flupentixol) in Multi-acting Receptor-targeted Antipsychotics Treated Schizophrenia PatientsCompletedNCT04898270Phase 4
• Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's DiseaseStatus unknownNCT04871464Phase 4
• Digital Mirror Therapy With Uni- and Bilateral Mirror Visual Feedback After Stroke: Treatment Effects and EEG EvidenceCompletedNCT04813120Not applicable
• Determination of COVID-19 Related Virus in Central Nervous SystemStatus unknownNCT04775784
• Optimized C-arm Cone Beam CT for the Endovascular Treatment (EVT) of Acute StrokeCompletedNCT04774510Not applicable
• Open-label Trial in Parkinson's Disease (PD)CompletedNCT04760769Phase 3
• The Onyx™ Trial For The Embolization Of The Middle Meningeal Artery For Chronic Subdural HematomaTerminatedNCT04742920Not applicable
• Cross-cultural Adaptation to the Spanish Population and Validation of the Community Balance & Mobility Scale (S-CB&M)CompletedNCT04710147
• Hypnoanalgesia for Dermatological Surgery in ChildrenCompletedNCT04707014Not applicable
• Pilot Study Concerning an Intelligent Activity-based Client-centred Training System in NeurorehabilitationCompletedNCT04692311Not applicable
• SMART-ALD - A New Lifestyle Intervention to Improve Quality of Life in Women With X-linked Adrenoleukodystrophy (X-ALD)CompletedNCT04687007Not applicable
• Bimanual Motor Skill Learning Through Robotics in Chronic Cerebellar Stroke Survivors and Healthy IndividualsActive, not recruitingNCT04642599Not applicable
• Blood-Brain Barrier Penetration of Therapeutic Agents in HumanCompletedNCT04571996Phase 1
• An Open-label, Phase 1/2 Trial of Gene Therapy 4D-310 in Adults With Fabry DiseaseActive, not recruitingNCT04519749Phase 1/2
• TOPAZ: Tucatinib in COmbination With Pembrolizumab And TrastuZumab in Patients With HER2-Positive Breast Cancer Brain MetastasesWithdrawnNCT04512261Phase 1/2
• Impact Dexmedetomidine on Postoperative Delirium in Patients After Intracranial Operation for Brain TumorCompletedNCT04494828Phase 4
• Neurocognitive Impairment in Pediatric Patients With Meningoencephalitis and Sepsis-associated EncephalopathyCompletedNCT04467762
• FDOPA PET and Nutritional Support in Parkinson's DiseaseActive, not recruitingNCT04459052Phase 2
• Multi-mode Stroke Rehabilitation System: Development and Validation of Clinical EfficacyCompletedNCT04441190Not applicable
• Dexmedetomidine for Prevention of Postoperative Delirium After Intracranial Operation for Brain TumorStatus unknownNCT04399343Phase 4
• Stroke Research Consortium in Northern Bavaria (STAMINA)CompletedNCT04357899
• Mindfulness-based Intervention to Promote Psychological Wellbeing in People With EpilepsyCompletedNCT04313686Not applicable
• Rheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic StrokeCompletedNCT04266639Not applicable
• Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-StrokeCompletedNCT04265664Not applicable
• The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine PatientsCompletedNCT04260035Not applicable
• Arm Boot Camp Study: Evaluation of a Program to Increase Upper Limb Recovery After StrokeCompletedNCT04232163Not applicable
• Long-Term Follow-up Safety After DDS Implantation With/Without CDNF InfusionsStatus unknownNCT04228653Phase 1/2
• 1H Magnetic Resonance Spectroscopy in Migraine PatientsCompletedNCT04220606Not applicable
• Validation of the Efficacy and Usability of the BELK Orthosis Knee Module in a Neurological Setting (BELK@CCP)WithdrawnNCT04173975Not applicable
• Comparison of Transcutaneous and Epidural Spinal Stimulation for Improving FunctionWithdrawnNCT04043715Not applicable
• pRESET for Occlusive Stroke TreatmentCompletedNCT03994822Not applicable
• CNS Tau Kinetics in Healthy Aging and Alzheimer's DiseaseCompletedNCT03938870
• High Dose Omega 3 in People at Risk for DementiaStatus unknownNCT03926351Phase 2
• Efficacy of End-Effector Robot-Assisted Gait Training in Subacute Stroke PatientsCompletedNCT03805009Not applicable
• Venezuelan Equine Encephalitis Monovalent Virus-Like Particle VaccineStatus unknownNCT03776994Phase 1
• Predicting Migraine Attacks Based on Environmental and Behavioral Changes as Detected From the SmartphoneTerminatedNCT03762902
• Evaluation of Safety and Efficacy of ProHance in Pediatric Patients <2yrsCompletedNCT03750188
• CKD-355 Drug-drug Interaction Study (CKD-355 DDI P1)CompletedNCT03569579Phase 1
• Human Epilepsy Project 2: Resistant Focal Seizures StudyCompletedNCT03531008
• Is Sphenopalatine Ganglion Block Treatment Effective on Postspinal HeadachesCompletedNCT03512977Not applicable
• DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot RetrievalCompletedNCT03494920Phase 3
• Combined Stimulation of STN and SNr for Dysphagia in Parkinson's DiseaseStatus unknownNCT03470324Not applicable
• Fluoxetine Opens Window to Improve Motor Recovery After StrokeCompletedNCT03448159Phase 2
• The Technology-assisted, High Intensive, Task-oriented Exercise TrialStatus unknownNCT03396939Not applicable
• Stroke Rehabilitation With Exoskeleton-assisted Gait.CompletedNCT03395717Not applicable
• STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke UnitsCompletedNCT03385928Phase 2
• Impact of Grape Consumption on Brain Metabolism and Neuropsychological Performance Over 1 YearCompletedNCT03361410Phase 2
• Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2)CompletedNCT03340493Phase 2
• MyndMove Therapy for Severe Hemiparesis of the Upper Limb Following StrokeStatus unknownNCT03323632Not applicable
• Safety, Tolerability, and Pharmacokinetics Study of NDX-1017CompletedNCT03298672Phase 1
• Trial to Assess the Pharmacokinetics, Safety, Tolerability of Oral Brexpiprazole in Children (6 to <13 Years Old) With Central Nervous System DisordersCompletedNCT03292848Phase 1
• Evaluating the Relationship Between Tau PET Imaging and CSF Biomarkers of AD (Alzheimer Disease) in HumansCompletedNCT03287765
• F 18 T807 PET (Positron Emission Tomograph )Scan for HIV Infected & UninfectedCompletedNCT03279523
• Effect of the Visual Information Change in Functional DystoniaTerminatedNCT03270189Not applicable
• Farber Disease Natural History StudyCompletedNCT03233841
• Safety/Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in ALSStatus unknownNCT03214146Phase 1
• The Third, Intensive Care Bundle With Blood Pressure Reduction in Acute Cerebral Hemorrhage TrialCompletedNCT03209258Not applicable
• Retrospective Study of MRI With MULTIHANCE at 0.10 and 0.05 mmol/Kg Dose in CNS PatientsCompletedNCT03147989

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