Cardio-Renal Syndrome clinical trials
The registry lists 85 studies for Cardio-Renal Syndrome across more than 10 countries. 20 are recruiting or about to start. 51 of them are mainly about Cardio-Renal Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Hospices Civils de Lyon (4) · Chinese PLA General Hospital (3) · Triomed AB (2) · Procyrion (2) · University of Giessen (2) · Hospital Civil de Guadalajara (2) · Odense University Hospital (2) · Haiyan Pan (2)
What is being tested here
Drugs under test in Cardio-Renal Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dapagliflozin | 1 | 1 | 3 |
| Finerenone | 1 | 0 | 1 |
| Empagliflozin | 1 | 1 | 1 |
| Furosemide | 0 | 0 | 3 |
| Dobutamine | 0 | 1 | 3 |
| Spironolactone | 0 | 0 | 3 |
| Simendan | 0 | 1 | 2 |
| Milrinone | 0 | 0 | 2 |
| Nesiritide | 0 | 0 | 2 |
| Candesartan | 0 | 0 | 1 |
Drug classes tested here SGLT2 inhibitors 2 open · Mineralocorticoid receptor antagonists (MRAs) 1 open · Diuretics 6
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6, phase 3 first
- Nov 2026The Treatment Effects of Empagliflozin on Renal Outcomes in Cardiorenal Syndrome Type 1 · Phase 3 · Chulalongkorn University
- Nov 2026The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure · Phase 3 · Instituto de Investigación Sanitaria Aragón
- Dec 2026Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults. · Robert Bosch Medical Center
- Dec 2026Kidney Sodium Content in Cardiorenal Patients · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Feb 2027Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVAD · SeaStar Medical
- Nov 2027French AKI Registry (FAKIR): A Multicenter Study on the In-Hospital Management and Outcomes of Severe Acute Kidney Injury in Nephrology Units · University Hospital, Strasbourg, France
Who these studies take
Of the 12 Cardio-Renal Syndrome studies recruiting now, 9 (75%) set no upper age limit and 2 (17%) stop at 75 or younger. 2 (17%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (8%) | 1 (8%) |
| 18 | 11 (92%) | 11 (92%) |
| 30 | 12 (100%) | 12 (100%) |
| 40 | 12 (100%) | 12 (100%) |
| 50 | 12 (100%) | 12 (100%) |
| 65 | 12 (100%) | 12 (100%) |
| 75 | 12 (100%) | 12 (100%) |
| 85 | 10 (83%) | 10 (83%) |
Across all 85 studies, recruiting or not: 11% stop at 75 or younger and 4% at 65; 6% take children; 0% are for women only and 2% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting1
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 85. Browse all 85 → or search them.
- Community Health Worker Nutrition Self-Management Support for Cardio-Kidney-Metabolic HealthNot yet recruitingNCT07918508Not applicable1 country
- Optimised Cardiovascular and Renal Protection in Patients With Chronic Kidney Disease and Cardiovascular DiseaseRecruitingNCT07835828Not applicable1 country
- Diuretics Alone vs. Aortix Endovascular Device for Acute Heart FailureRecruitingNCT05677100Not applicable2 countries
- Cardiorenal Syndrome: Characteristics and Prognostic Impact in Advanced Heart FailureNot yet recruitingNCT07666516Not applicable1 country
- The Treatment Effects of Empagliflozin on Renal Outcomes in Cardiorenal Syndrome Type 1RecruitingNCT06030843Phase 2/31 country
- Spironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety StudyNot yet recruitingNCT07523867Phase 4
- Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVADRecruitingNCT03836482Not applicable1 country
- Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults.RecruitingNCT074641061 country
- Exercise Rehabilitation for Cardiorenal Syndrome in HFrEF PatientsRecruitingNCT07167368Not applicable1 country
- Screening of Predictive Biomarkers for Cardiorenal SyndromeRecruitingNCT071396261 country
- Dapagliflozin for Cardio-renal Protection After ICU DischargeRecruitingNCT07025629Phase 31 country
- Efficacy and Safety of Compression Boots in Patients With Acute Decompensated Heart Failure.Not yet recruitingNCT07377019Not applicable1 country
- Cardio-Renal RegistryRecruitingNCT065218011 country
- French AKI Registry (FAKIR): A Multicenter Study on the In-Hospital Management and Outcomes of Severe Acute Kidney Injury in Nephrology UnitsNot yet recruitingNCT07123324
- The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart FailureRecruitingNCT07008365Phase 31 country
- Decongestion Guided By VExUS Score Or Lung Ultrasound For Renal Recovery In Patients With Cardiorenal Syndrome Type -1Enrolling by invitationNCT06786728Not applicable1 country
- Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart FailureRecruitingNCT06714409Not applicable1 country
- Effects of a Supervised Training Program on Functional Capacity in Patients With HF and Cardiorenal SyndromeNot yet recruitingNCT06640140Not applicable1 country
- Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic ResistanceNot yet recruitingNCT06174623Not applicable2 countries
- Ultrasound Guided Diuretic Therapy in Type 1 Cardiorenal SyndromeRecruitingNCT06065163Not applicable1 country
- Ultrafiltration Versus Medical Therapies in the Management of the Cardio Renal SyndromeCompletedNCT02846337Not applicable1 country
- Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal FunctionCompletedNCT07186062Phase 41 country
- Monitoring of the Sympathetic/Vagal Balance Through Multiparametric Analysis of Heart Rate Variability (HRV)Active, not recruitingNCT074718021 country
- Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility StudyCompletedNCT06111768Phase 21 country
- Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac SurgeryTerminatedNCT036848761 country
- Kidney Sodium Content in Cardiorenal PatientsActive, not recruitingNCT04170855Not applicable1 country
- A Prospective, Multicenter, Randomized, Blinded, Sham-controlled, Feasibility Study of Renal Denervation in Patients With Chronic Heart FailureTerminatedNCT04947670Not applicable1 country
- Cardiorenal and Metabolic Effects of Nighttime EatingCompletedNCT06588088Not applicable1 country
- SCD for CRS in Congestive Heart Failure (CHF) (No Left Ventricular Assist Device)SuspendedNCT04589065Not applicable1 country
- VExUS in Patients With Acute Heart FailureCompletedNCT063974041 country
- The Aortix CRS Pilot StudyCompletedNCT04145635Not applicable2 countries
- Renal Venous Flow and Cardiac Surgery-associated Acute Kidney InjuryCompletedNCT037536071 country
- Volume Optimization Incorporating Negative Pressure Diuresis in Heart Failure (VOID-HF)CompletedNCT04227977Not applicable1 country
- Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting ListWithdrawnNCT04782245Phase 21 country
- Effect on Kidney Function Recovery Guiding Decongestion With VExUS in Patients With Cardiorenal Syndrome 1CompletedNCT05927285Not applicable1 country
- Renal Denervation in Patients With Chronic Heart FailureWithdrawnNCT02085668Not applicable4 countries
- Predictive Value of Venous Excess Ultrasound Score in Management of Cardiorenal PatientsStatus unknownNCT05368766
- Implementation of Telerehabilitation In Support of HOme-based Physical Exercise for Heart FailureCompletedNCT03183323Not applicable1 country
- CR Aim #2 - AT1 Receptor Blockade & ACE Inhibition Effect on Humoral FunctionCompletedNCT01678794Phase 1/21 country
- Acute Kidney Injury After Cardiac SurgeryStatus unknownNCT05079724
- Roxadustat Combined With Sacubitril Valsartan Sodium Tablets in the Treatment of Cardiorenal Anemia SyndromeStatus unknownNCT05053893Not applicable1 country
- Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention IICompletedNCT050508771 country
- Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary InterventionCompletedNCT044079361 country
- Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney InjuryStatus unknownNCT050345881 country
- Levosimendan Infusion in Critically Ill Patients With Cardiogenic ShockCompletedNCT04917497
- Alfapump Direct Sodium Removal (DSR) Feasibility StudyCompletedNCT04116034Not applicable2 countries
- Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart FailureStatus unknownNCT04618601Phase 41 country
- The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide.CompletedNCT04393493Phase 21 country
- Damage and Renal Clearance of Glycocalyx in Cardiac SurgeryCompletedNCT043329521 country
- Levosimendan Versus Dobutamine for Renal Function in Heart FailureCompletedNCT02133105Phase 31 country