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TerminatedNCT03684876DECONGESTUpdated Jun 25, 2026

Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery

An observational study in Cardiorenal Syndrome, sponsored by Centre Hospitalier Universitaire, Amiens. Terminated at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-25.

Sponsored by Centre Hospitalier Universitaire, Amiens · Observational

Why this study was terminated
Recruitment difficulties
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
9
Ages
18 Years and older
Sex
All
01

Study summary

Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics

Read the detailed description

The study will compare cardiac and renal data before and 6 hours after use of diuretic

  • Echocardiographic measure of right function (S wave, TAPSE, ventricle surfaces, inferior vena cava diameter) and left function (LVEF, cardiac output
  • Renal function: cumulative diuresis, creatinine level variation and incidence of acute kidney injury using KDIGO classification (creatinine level>26.5 or diuresis\<0.05 ml kg-1 h-1)
02

Conditions studied

  • Cardiorenal Syndrome

Keywords

  • cardiac surgery
  • venous congestion
  • diuretic depletion
03

In context

Cardio-Renal Syndrome

85 studies on the registry are indexed under Cardio-Renal Syndrome; 20 are open to participants now.

This study's enrollment of 9 is below the median of 148 across 26 observational studies indexed under Cardio-Renal Syndrome.

Browse Cardio-Renal Syndrome studies →

Lead sponsor

Centre Hospitalier Universitaire, Amiens is the lead sponsor of 586 studies on the registry; 185 are open to participants now.

Browse Centre Hospitalier Universitaire, Amiens studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

patient age >=18 years

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

patient undergoing elective cardiac surgery under cardiopulmonary bypass

Exclusion criteria

Exclusion Criteria:

  • heart transplantation
  • use of vasopressor
  • chronic renal disease (DGF under 30 ml min-1)
  • endocarditis
  • patient under ECLS or CPIA
  • patient under 18-year-old
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
9 participants (actual)
Patient registry
No

Interventions

  • Procedurediuretic use

    use of diuretic

06

What researchers measure

Primary outcomes

  1. change in renal glomerular filtration before and 6 hours after use of diurectic

    change in renal glomerular filtration before and 6 hours after use of diurectic

    Time frame: at baseline (o hours) and 6 hours after use of diuretic

07

Study locations

1 site
  • CHU Amiens Picardie
    Amiens, France
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jun 2018 to primary completion in Jun 2020, 24 months.

How these figures are worked out, and which studies are left out of them.

Registered
Jul 5, 2018
First posted
Sep 26, 2018
StartActual
Jun 1, 2018
Primary completionActual
Jun 1, 2020
CompletionActual
Jun 1, 2020
Last update
Jun 25, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 25, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03684876
Lead sponsor
Centre Hospitalier Universitaire, Amiens
Responsible party
Sponsor
First posted
Sep 26, 2018
Start date
Jun 1, 2018
Primary completion
Jun 1, 2020
Completion
Jun 1, 2020
Last update
Jun 25, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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