An observational study in Glycocalyx and Cardio-Renal Syndrome, sponsored by Miguel Ayala León. Completed at 1 site in Mexico. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-04-09.
Sponsored by Miguel Ayala León · Observational
The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory.
The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.
76 studies on the registry are indexed under Cardio-Renal Syndrome; 22 are open to participants now.
This study's enrollment of 21 is below the median of 150 across 26 observational studies indexed under Cardio-Renal Syndrome.
Browse Cardio-Renal Syndrome studies →Miguel Ayala León is the lead sponsor of 4 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who meet the selection criteria undergoing cardiac surgery for a single valve change or replacement.
Exclusion Criteria:
Extracorporeal circulation time
Duration of Extracorporeal Circulation in minutes
Time frame: 2 hours
Aortic clamping time
Duration of aortic clamping time in minutes
Time frame: 2 hours
Hyaluronic acid levels in blood before surgery
Quantity of hyaluronic acid in blood before surgery
Time frame: 30 minutes
Hyaluronic acid levels in blood after surgery
Quantity of hyaluronic acid in blood after surgery
Time frame: 30 minutes
Hyaluronic acid levels in urine before surgery
Quantity of hyaluronic acid in urine before surgery
Time frame: 30 minutes
Hyaluronic acid levels in urine after surgery
Quantity of hyaluronic acid in urine before surgery
Time frame: 30 minutes
Sydecan -1 levels in blood before surgery
Quantity of Sydecan -1 in blood before surgery
Time frame: 30 minutes
Sydecan -1 levels in blood after surgery
Quantity of Sydecan -1 in blood after surgery
Time frame: 30 minutes
Sydecan -1 levels in urine before surgery
Quantity of Sydecan -1 in urine before surgery
Time frame: 30 minutes
Sydecan -1 levels in urine after surgery
Quantity of Sydecan -1 in urine after surgery
Time frame: 30 minutes
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Miguel Ayala León