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RecruitingNCT06486506ProFemuReUpdated May 26, 2026

Proximal Femur Reconstruction Following Resection of Primary Bone Tumors: Analysis of the Clinical and Radiographic Results

An observational study in Bone Tumor and Bone Cancer, sponsored by Costantino Errani. Recruiting at 1 site in Italy. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-05-26.

Sponsored by Costantino Errani · Observational

From the registry’s dates

  • Started Apr 2024; still recruiting 2 years 6 months later.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
150
Ages
18 Years to 90 Years
Sex
All
01

Study summary

From the archives of the Rizzoli institute all the patients (approximately 150 patients) undergoing oncological reconstruction of proximal femur from 01/01/1991 to 31/12/2023.

A review will be made from the medical records, radiological imaging, and histological data of these patients

02

Conditions studied

  • Bone Tumor
  • Bone Cancer

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Keywords

  • Proximal Femur Reconstruction
  • primary bone tumors
  • imaging
03

In context

Bone Neoplasms

258 studies on the registry are indexed under Bone Neoplasms; 68 are open to participants now.

This study's planned enrollment of 150 is above the median of 101 across 82 observational studies indexed under Bone Neoplasms.

Browse Bone Neoplasms studies →

Lead sponsor

Costantino Errani is the lead sponsor of 5 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Male and female patients surgically treated with an oncological reconstruction of the proximal femur at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2023

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male and female patients surgically treated with an oncological reconstruction of the proximal femur at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2023
  • Age: 18-90 years old (at the time of primary surgery)
  • Diagnosis of bone sarcoma
  • Patients with available clinical and imaging data

Exclusion criteria

Exclusion Criteria:

  • At least one inclusion criterion not met
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
150 participants (estimated)
Patient registry
No

Groups and cohorts

  • Patients

    Male and female patients surgically treated with an oncological reconstruction of the proximal femur at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2023

    Other: Analysis

Interventions

  • OtherAnalysis

    Analysis and review of imaging and clinical data

06

What researchers measure

Primary outcomes

  1. longevity of the reconstruction

    evaluation of the longevity of the reconstruction, meaning reconstruction failure-free survival after surgery

    Time frame: At baseline (Day 0)

Secondary outcomes

  1. Musculoskeletal tumour society (MSTS) functional evaluation

    The MSTS questionnaire consists of six domains, each scored on a scale from 0 to 5, with a higher score indicating better function.

    Time frame: at baseline (day 0)

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Tobey D, Wing C, Calkins T, Heck RK. The Use of Proximal Femur Replacement for the Management of Oncologic Lesions in the Proximal Femur: A Review. Orthop Clin North Am. 2023 Jan;54(1):23-35. doi: 10.1016/j.ocl.2022.08.006. Epub 2022 Oct 23. PubMed 36402508 ↗
  • Menendez LR, Ahlmann ER, Kermani C, Gotha H. Endoprosthetic reconstruction for neoplasms of the proximal femur. Clin Orthop Relat Res. 2006 Sep;450:46-51. doi: 10.1097/01.blo.0000229332.91158.05. PubMed 16906093 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 26, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06486506
Lead sponsor
Costantino Errani
Responsible party
Costantino Errani (Principal Investigator, Istituto Ortopedico Rizzoli) — Sponsor-investigator
First posted
Jul 3, 2024
Start date
Apr 29, 2024
Primary completion
Dec 31, 2026 (estimated)
Completion
Dec 31, 2026 (estimated)
Last update
May 26, 2026

Study contacts

Costantino Errani, MD
Contact
costantino.errani@ior.it
0516366 ext. 103
Roberta Laranga, PhD
Contact
roberta.laranga@ior.it
051636 ext. 5123

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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