Anemia, Sickle Cell: all 1,125 studies

Page 3 of 12. Open to participants first (238), then studies with results posted, then the rest; newest registration first within each.

• Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene TherapyEnrolling by invitationNCT04628585
• Lidocaine Intravenous in the Emergency Department For Sickle Cell CrisisNot yet recruitingNCT04614610Phase 2
• Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RICRecruitingNCT04528355
• The BENeFiTS Trial in Beta Thalassemia IntermediaEnrolling by invitationNCT04432623Phase 1/2
• Sickle Cell Disease and the Genomic and Gene Therapy Needs of StakeholdersRecruitingNCT04416178
• ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic DisordersRecruitingNCT04398628
• SMILES: Study of Montelukast in Sickle Cell DiseaseRecruitingNCT04351698Phase 2/3
• A Long-term Follow-up Study in Participants Who Received CTX001Enrolling by invitationNCT04208529Phase 3
• A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCDRecruitingNCT04201210Phase 2
• A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell DiseaseRecruitingNCT04166526
• Cerebral Oxygen Metabolism in ChildrenRecruitingNCT04157179Not applicable
• AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell DepletionRecruitingNCT04099966Phase 2
• Hydroxyurea Exposure Limiting Pregnancy and Follow-Up LactationRecruitingNCT04093986
• A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell DiseaseRecruitingNCT04055818Phase 1
• High-flow Oxygen for Vaso-occlusive Pain CrisisRecruitingNCT03976180Not applicable
• Outcomes Mandate National Integration With Cannabis as MedicineRecruitingNCT03944447Phase 2
• Collection of Human Biospecimens for Basic and Clinical Research Into Globin VariantsRecruitingNCT03937817
• The Implementation of the Automated Erythrocytapheresis in Egyptian Sickle Cell Disease CenterRecruitingNCT03903289Not applicable
• Pediatric -Adult Care Transition Program of Patients With Sickle Cell DiseaseRecruitingNCT03786549Not applicable
• Managed Access Programs for SEG101, CrizanlizumabAvailableNCT03720626
• T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other AnemiasRecruitingNCT03653338Phase 1/2
• Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell DiseaseRecruitingNCT03587272Phase 2
• Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell DiseaseRecruitingNCT03353584Not applicable
• Sickle-cell Disease Registry of the GPOHRecruitingNCT03327428
• Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling DonorRecruitingNCT03214354Phase 2
• Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant DisordersRecruitingNCT03128996Phase 1/2
• Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell DiseaseRecruitingNCT03121001Phase 2
• Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)RecruitingNCT02824471
• Investigation of the Genetics of Hematologic DiseasesRecruitingNCT02720679
• Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell DiseaseRecruitingNCT02675959Phase 2
• Measures of Respiratory Health (MRH)RecruitingNCT02657837
• Arginine Therapy for the Treatment of Pain in Children With Sickle Cell DiseaseRecruitingNCT02447874Phase 1/2
• Sickle Cell Clinical Research and Intervention ProgramRecruitingNCT02098863
• Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCTRecruitingNCT01962415Phase 2
• Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood TransplantsAvailableNCT01881334
• Study of Panobinostat (LBH589) in Patients With Sickle Cell DiseaseRecruitingNCT01245179Phase 1
• Blood Sampling for Research Related to Sickle Cell DiseaseRecruitingNCT00542230
• Blood Collection for Research Related to Certain Diseases Involving Blood VesselsEnrolling by invitationNCT00047996
• Risk Factors, Costs, and Impacts of ED BoardingCompletedNCT07532564Results posted
• Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ FunctionActive, not recruitingNCT06145282Phase 1/2Results posted
• Development and Adaptation of I-STRONG for SCDCompletedNCT06110754Not applicableResults posted
• Siplizumab for Sickle Cell Disease TransplantTerminatedNCT06078696Phase 1/2Results posted
• Voxelotor CYP and Transporter Cocktail Interaction StudyCompletedNCT05981365Phase 1Results posted
• A GBT021601 ADME Microtracer Study in Healthy VolunteersCompletedNCT05718687Phase 1Results posted
• Gerofit Exercise Intervention for Older Adults With Sickle Cell Disease (SICKLE-FIT Study)CompletedNCT05714098Not applicableResults posted
• GBT021601-022: A Study of GBT021601 in Participants With Sickle Cell Disease (SCD)TerminatedNCT05632354Phase 2/3Results posted
• Safety, Efficacy, Pharmacokinetic, and Pharmacodynamic Study of ALXN1820 in Adult Participants With Sickle Cell DiseaseTerminatedNCT05565092Phase 2Results posted
• Resolution of Sickle Cell Leg Ulcers With VoxelotorTerminatedNCT05561140Phase 3Results posted
• Evaluation of Low-cost Techniques for Detecting Sickle Cell Disease and β-thalassemia in Nepal and CanadaCompletedNCT05506358Not applicableResults posted
• Hydroxyurea and EPO in Sickle Cell DiseaseCompletedNCT05451940Phase 1/2Results posted
• Study of MGTA-145 and Plerixafor in Patients With Sickle Cell DiseaseTerminatedNCT05445128Phase 2Results posted
• A Study to Learn About Sickle Cell Disease In Adult PatientsCompletedNCT05407805Results posted
• COVID-19 Testing in Underserved and Vulnerable PopulationsTerminatedNCT05315908Not applicableResults posted
• Sickle Cell Disease (SCD) Bone Pain StudyActive, not recruitingNCT05283148Not applicableResults posted
• AB1 in Adult Patients With Sickle Cell Disease (SCD)TerminatedNCT05261711Phase 1/2Results posted
• Voxelotor Neurocognitive Function StudyTerminatedNCT05228834Phase 3Results posted
• COVID-19 Vaccine Response in Sickle Cell DiseaseCompletedNCT05139992Results posted
• Pharmacokinetics and Pharmacodynamics of Rifaximin Novel Formulations in Patients With Sickle Cell DiseaseCompletedNCT05098028Phase 2Results posted
• A Study to Evaluate GBT021601-012 Single Dose and Multiple Dose in Participants With Sickle Cell Disease (SCD)CompletedNCT04983264Phase 1Results posted
• A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive CrisesCompletedNCT04935879Phase 3Results posted
• Oxbryta® Product Registry An Observational Study Designed to Evaluate the Effect of Oxbryta in Individuals With SCDTerminatedNCT04930445Results posted
• A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive CrisesTerminatedNCT04927247Phase 3Results posted
• Home-Based Intervention for Chronic Pain in Adults With Sickle Cell DiseaseCompletedNCT04906707Not applicableResults posted
• Sickle Cell Disease Treatment With Arginine Therapy (STArT) TrialCompletedNCT04839354Phase 3Results posted
• Study to Assess Efficacy and Safety of VIT-2763 (Vamifeport) in Subjects With Sickle Cell DiseaseCompletedNCT04817670Phase 2Results posted
• An Indian Multi-centric Phase IV Study to Assess the Safety of Crizanlizumab in Sickle Cell Disease PatientsCompletedNCT04662931Phase 4Results posted
• Building Adaptive Coping and Knowledge to Improve Daily LifeCompletedNCT04602728Not applicableResults posted
• Designing an Implementation Strategy for Delivering Routine Mental Health Screening and TreatmentTerminatedNCT04587661Not applicableResults posted
• PINPOINT: Gaming Technology for SCD PainCompletedNCT04579926Not applicableResults posted
• Pilot Study PBSCT With TCRab Depletion For HemoglobinopathiesCompletedNCT04523376Not applicableResults posted
• Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell DiseaseCompletedNCT04514510Phase 2Results posted
• A Study Aimed to Assess the Needs of Subjects With Sickle Cell Disease and Healthcare Professionals Managing Sickle Cell Disease Patients in Selected Nigerian CentresCompletedNCT04505969Results posted
• Red Cell Half Life Determination in Patients With and Without Sickle Cell DiseaseCompletedNCT04476277Early Phase 1Results posted
• A Study of IMR-687 in Subjects With Sickle Cell DiseaseTerminatedNCT04474314Phase 2Results posted
• Biotin-RBC Transfusion in SCDCompletedNCT04426591Phase 1Results posted
• Desmopressin for Bedwetting in Children With SCDTerminatedNCT04420585Phase 4Results posted
• Actigraphy Improvement With Voxelotor (ActIVe) StudyCompletedNCT04400487Phase 4Results posted
• SMYLS: A Self-management Program for Youth Living With Sickle Cell DiseaseCompletedNCT04289311Not applicableResults posted
• Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCDTerminatedNCT04247594Phase 2Results posted
• Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell DiseaseTerminatedNCT04218084Phase 3Results posted
• Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) for Patients With Severe Sickle Cell DiseaseTerminatedNCT04207320Not applicableResults posted
• Open-Label Extension of VoxelotorTerminatedNCT04188509Phase 3Results posted
• Daily Vitamin D for Sickle-cell Respiratory ComplicationsCompletedNCT04170348Phase 2Results posted
• RHD Genotype Matched Red Cells for Anti-DCompletedNCT04156906Early Phase 1Results posted
• Acupuncture for Adults With Sickle Cell Disease (SCD): A Feasibility StudyTerminatedNCT04156399Not applicableResults posted
• Integration of mHEALTH Into the Care of Patients With Sickle Cell Disease to Increase Hydroxyurea UtilizationCompletedNCT04080167Not applicableResults posted
• Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell DiseaseCompletedNCT04053764Phase 2Results posted
• The Impact of Oxidative Stress on Erythrocyte BiologyTerminatedNCT04028700Phase 2Results posted
• A Dose-Finding Study of AG-348 in Sickle Cell DiseaseCompletedNCT04000165Early Phase 1Results posted
• Imatinib for Pain in Sickle Cell AnemiaTerminatedNCT03997903Phase 1/2Results posted
• A Study of SHP655 (rADAMTS13) in Sickle Cell DiseaseCompletedNCT03997760Phase 1Results posted
• A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related PriapismCompletedNCT03938454Phase 2Results posted
• Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic ConditionsCompletedNCT03938324Not applicableResults posted
• Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell DiseaseTerminatedNCT03933397Phase 3Results posted
• A Study to Assess the Safety and Pharmacokinetics of HBI-002, an Oral Carbon Monoxide Therapeutic, in Healthy VolunteersCompletedNCT03926819Phase 1Results posted
• Hydroxyurea Therapy: Optimizing Access in Pediatric Populations EverywhereTerminatedNCT03825341Phase 2Results posted
• Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease PatientsActive, not recruitingNCT03814746Phase 3Results posted
• SIKAMIC (SIklos on Kidney Function and AlbuMInuria Clinical Trial)CompletedNCT03806452Phase 2Results posted
• Pharmacokinetics of Oral Hydroxyurea SolutionCompletedNCT03763656Phase 1/2Results posted
• A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell DiseaseCompletedNCT03745287Phase 2/3Results posted

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