Adrenal Hyperplasia, Congenital clinical trials
The registry lists 101 studies for Adrenal Hyperplasia, Congenital across more than 10 countries. 28 are recruiting or about to start. 85 of them are mainly about Adrenal Hyperplasia, Congenital (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Who runs them
Neurocrine UK Limited (8) · Neurocrine Biosciences (6) · Assistance Publique - Hôpitaux de Paris (6) · Spruce Biosciences (5) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (4) · Crinetics Pharmaceuticals Inc. (4) · Hospices Civils de Lyon (4) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (3)
What is being tested here
Drugs under test in Adrenal Hyperplasia, Congenital studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Atumelnant | 3 | 2 | 4 |
| Asedebart | 2 | 0 | 2 |
| Osilodrostat | 2 | 0 | 2 |
| Hydrocortisone | 1 | 6 | 17 |
| Crinecerfont | 1 | 2 | 6 |
| Metyrapone | 1 | 0 | 2 |
| Tildacerfont | 0 | 0 | 3 |
| Pd-132301 hydrochloride | 0 | 0 | 2 |
| Dexamethasone | 0 | 0 | 2 |
| Abiraterone Acetate | 0 | 0 | 2 |
Drug classes tested here Corticosteroids 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9, phase 3 first
- May 2027A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia · Phase 3 · Crinetics Pharmaceuticals Inc.
- Dec 2026Growing up With the Young Endocrine Support System (YESS!) · dr. Laura C. G. de Graaff-Herder
- Dec 2026Syndromes With Neonatal Salt Loss: Not Only Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency (21OH-ISC) · IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Dec 2026Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment · Federico II University
- Jan 2027Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS) · Mayo Clinic
- Mar 2027Pediatric Congenital Adrenal Hyperplasia Management: Regret and Long-term Outcomes · University Hospital, Lille
- Mar 2027Parenting and CAH - 21-hydroxylase Deficiency · Assistance Publique - Hôpitaux de Paris
- May 2027Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of OMS1620 · OMass Therapeutics Australia Proprietary Ltd
- Sep 2027Evaluation of Circadian Hormonal Balance: LC-MS/MS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal Hyperplasia · Assistance Publique - Hôpitaux de Paris
Who these studies take
Of the 20 Adrenal Hyperplasia, Congenital studies recruiting now, 10 (50%) set no upper age limit and 9 (45%) stop at 75 or younger. 7 (35%) take children under 18. 2 (10%) are for women only and 1 (5%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (20%) | 4 (20%) |
| 18 | 17 (85%) | 16 (80%) |
| 30 | 17 (85%) | 16 (80%) |
| 40 | 16 (80%) | 15 (75%) |
| 50 | 16 (80%) | 15 (75%) |
| 65 | 16 (80%) | 15 (75%) |
| 75 | 11 (55%) | 11 (55%) |
| 85 | 10 (50%) | 10 (50%) |
Across all 101 studies, recruiting or not: 57% stop at 75 or younger and 50% at 65; 51% take children; 10% are for women only and 4% for men only; 22% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Studies
Recruiting first, then most recently updated. Showing 50 of 101. Browse all 101 → or search them.
- Natural History Study of Patients With Excess AndrogenRecruitingNCT002501591 country
- A Study in Pediatric Participants With Congenital Adrenal Hyperplasia (Balance-CAH)RecruitingNCT07159841Phase 2/313 countries
- A Study to Evaluate Atumelnant in Adults With Congenital Adrenal HyperplasiaRecruitingNCT07144163Phase 315 countries
- Adrenal Diseases in the Population of Modena: A Clinical-Epidemiological Database of Patients Referred to the Adrenal Disorders Outpatient Clinic of the Clinical Unit of Endocrinology at the Modena University Hospital (AOU Modena)RecruitingNCT079201981 country
- Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS)RecruitingNCT07247058Phase 41 country
- Development of Healthcare Transition for Patients With Congenital Adrenal HyperplasiaNot yet recruitingNCT076117861 country
- An Extension Trial of Asedebart in Participants With Congenital Adrenal HyperplasiaNot yet recruitingNCT07859293Phase 2
- Efficacy, Safety, Tolerability, and Pharmacokinetics of NBIP-01435 in Adult Participants With Classic Congenital Adrenal Hyperplasia (CAH)Not yet recruitingNCT07850739Phase 2
- Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACSRecruitingNCT07138274Phase 21 country
- Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Crinecerfont in Participants With Classic Congenital Adrenal Hyperplasia (CAH) Who Are Less Than 4 Years OldRecruitingNCT07536269Phase 21 country
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of OMS1620Not yet recruitingNCT07811089Phase 1
- Parenting and CAH - 21-hydroxylase DeficiencyRecruitingNCT069001531 country
- Pediatric Congenital Adrenal Hyperplasia Management: Regret and Long-term OutcomesRecruitingNCT077812671 country
- Evaluation of Circadian Hormonal Balance: LC-MS/MS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal HyperplasiaNot yet recruitingNCT077182301 country
- An Extension Study to Evaluate Safety and Efficacy of Atumelnant in Participants With Congenital Adrenal HyperplasiaRecruitingNCT06712823Phase 26 countries
- Hydrocortisone Modified-release in Adults: Real-world Monitoring of Longitudinal Outcomes in coNgenital Adrenal hYperplasiaNot yet recruitingNCT07622030
- Syndromes With Neonatal Salt Loss: Not Only Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency (21OH-ISC)RecruitingNCT074738041 country
- A Trial of Lu AG13909 in Participants With Congenital Adrenal HyperplasiaRecruitingNCT05669950Phase 1/29 countries
- Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)RecruitingNCT07104812Phase 21 country
- Institutional Registry of Rare DiseasesRecruitingNCT065737231 country
- Congenital Adrenal Hyperplasia Once Daily Hydrocortisone TreatmentRecruitingNCT03760835Phase 41 country
- Fertility And Sexual Function In CAH: CALLIOPERecruitingNCT070994561 country
- Electronic Registry of Male Patients With Congenital Adrenal Hyperplasia 21-hydroxylase DeficiencyRecruitingNCT067544231 country
- Testicular Adrenal Rest Tumor in Congenital Adrenal Hyperplasia Patients Attending Assuit University Children HospitalNot yet recruitingNCT06564220
- Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted AdrenalectomyRecruitingNCT060500571 country
- Growing up With the Young Endocrine Support System (YESS!)Not yet recruitingNCT04252001Not applicable4 countries
- GROWing Up With Rare GENEtic SyndromesRecruitingNCT044633161 country
- China Adrenal Disease RegistryRecruitingNCT048904441 country
- Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal HyperplasiaCompletedNCT05063994Phase 33 countries
- A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAHCompletedNCT03062280Phase 31 country
- Comparison of Chronocort® With Standard Glucocorticoid Therapy in Patients With Congenital Adrenal HyperplasiaCompletedNCT02716818Phase 31 country
- Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAHCompletedNCT01735617Phase 21 country
- Metyrapone for Mild Autonomous Cortisol Secretion (MACS)Active, not recruitingNCT06106295Phase 21 country
- An Open Label Study in Healthy Volunteers to Compare Chronocort® to HydrocortisoneCompletedNCT03019614Phase 1
- A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort FormulationsCompletedNCT03051893Phase 1
- Open-label Comparison of Chronocort® Versus Standard Glucocorticoid Replacement TherapyWithdrawnNCT03532022Phase 31 country
- Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (TouCAHn)CompletedNCT05907291Phase 27 countries
- Pharmacokinetics, Safety and Tolerability of Crinecerfont in Participants With Congenital Adrenal Hyperplasia Who Are Less Than 2 Years OldActive, not recruitingNCT07187375Phase 21 country
- Long-term Safety Study of Chronocort in the Treatment of Participants With Congenital Adrenal HyperplasiaCompletedNCT05299554Phase 33 countries
- Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal HyperplasiaActive, not recruitingNCT04490915Phase 318 countries
- Retrospective Multicentre Study on the Impact of Neonatal Screening for Congenital Adrenal Hyperplasia in ItalyCompletedNCT067287481 country
- A Phase 2 Study to Evaluate the Safety, Efficacy and PK of Tildacerfont in Children Aged 2-17 Years With CAHTerminatedNCT05128942Phase 21 country
- A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH)Active, not recruitingNCT04783181Phase 1/21 country
- Prenatal Dex StudyCompletedNCT02795871Not applicable1 country
- A Study of a Virtual Education-Based Transition Intervention to Improve Transition Readiness in Adolescent and Young Adults With Congenital Adrenal HyperplasiaWithdrawnNCT05663320Not applicable1 country
- Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1TerminatedNCT02574910Phase 11 country
- Study of SPR001 in Adults With Classic Congenital Adrenal HyperplasiaCompletedNCT03257462Phase 21 country
- A Ph2b to Evaluate Tildacerfont in the Reduction of Glucocorticoid Steroid Doses in Adult CAHTerminatedNCT04544410Phase 216 countries
- Investigation of the Etiology of Hypertension and Endothelial Damage in Patients With Cytochrome P450 Oxidoreductase DeficiencyCompletedNCT067566201 country
- Baby Detect : Genomic Newborn ScreeningCompletedNCT056874741 country