An observational study in Testicular Adrenal Rest Tumor and Congenital Adrenal Hyperplasia, sponsored by Assiut University. Not yet recruiting. Open to male participants aged 4 Years to 18 Years. Per ClinicalTrials.gov, last updated 2024-08-21.
Sponsored by Assiut University · Observational
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assessment of the risk factors contributing for TART development in a male child with congenital adrenal hyperplasia.
Congenital adrenal hyperplasia (CAH) is one of the most frequent endocrine disorders. It is characterized by deficient activity of one of the enzymes necessary for adrenal Cortisol synthesis. Autosomal recessive inheritance of deficient 21-hydroxylase (21 OH) activity accounts for more than 90% of cases. [1]
One of the most important and frequently detected complications in males with congenital adrenal hyperplasia (CAH) is the development of testicular adrenal rest tumours (TARTs). . [2],[3]
Testicular adrenal rest tumor is a benign tumor originating from adrenal cells within the testicles; the adrenal cells migrate at 8 weeks of gestation from the urogenital ridge along with the gonadal cells to the testicle. The exact mechanism underlying tumor growth and development is still not well understood . [4],[5]
The correct diagnosis of TART is important for differential diagnosis with malignant testis tumors, which need orchiectomy, as opposed to TART, usually treated exclusively with exogenous steroids. [6].
Although TARTs are always benign, their location in the rete testis could obstructs the seminiferous tubules and causes gonadal dysfunction and infertility. Therefore, it is important to detect and treat TARTs at an early stage, especially in adolescents or young adults. [5],[7]
testicular ultrasound should be done in order to evaluate the presence of these lesions, its size, location, and characteristics. [9]
TARTs in children have mostly been presented as case reports in the literature, and only a limited number of studies have described the prevalence of TARTs in large populations of children . [2],[8]
As not all male CAH patients are affected by this complication, attempts have been made to identify the risk factors for the development of TARTs . [7]
101 studies on the registry are indexed under Adrenal Hyperplasia, Congenital; 28 are open to participants now.
This study's planned enrollment of 30 is below the median of 61 across 44 observational studies indexed under Adrenal Hyperplasia, Congenital.
Browse Adrenal Hyperplasia, Congenital studies →Assiut University is the lead sponsor of 5,081 studies on the registry; 2,179 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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male patients diagnosed as congenital adrenal hyperplasia based on clinical manifestations and laboratory investigations from age of 4 years to age of 18 years.
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Testicular adrenal rest tumor in congenital adrenal hyperplasia patients attending Assiut University Children Hospital
Assessment of risk factors contributing for TART development in a child with congenital adrenal hyperplasia.
Time frame: Baseline
No study locations are listed for this record.
Start is estimated for Oct 2024; primary completion for Oct 2025, 12 months later.
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This study is not yet recruiting, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.
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Adrenal Hyperplasia, Congenital →