Neurocrine Biosciences: Adrenal Hyperplasia, Congenital trials

The registry lists 16 Adrenal Hyperplasia, Congenital studies with Neurocrine Biosciences as lead sponsor. 2 are open to participants now and 9 have results posted.

Phase 1 4Phase 2 7Phase 3 6(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Efficacy, Safety, Tolerability, and Pharmacokinetics of NBIP-01435 in Adult Participants With Classic Congenital Adrenal Hyperplasia (CAH)Not yet recruitingNCT07850739Phase 2
• Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Crinecerfont in Participants With Classic Congenital Adrenal Hyperplasia (CAH) Who Are Less Than 4 Years OldRecruitingNCT07536269Phase 2
• Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal HyperplasiaCompletedNCT05063994Phase 3Results posted
• Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)Active, not recruitingNCT04806451Phase 3Results posted
• Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal HyperplasiaActive, not recruitingNCT04490915Phase 3Results posted
• Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-74788 (Crinecerfont) in Pediatric Participants With Congenital Adrenal HyperplasiaCompletedNCT04045145Phase 2Results posted
• Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-74788 in Adults With Congenital Adrenal HyperplasiaCompletedNCT03525886Phase 2Results posted
• A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAHCompletedNCT03062280Phase 3Results posted
• Comparison of Chronocort® With Standard Glucocorticoid Therapy in Patients With Congenital Adrenal HyperplasiaCompletedNCT02716818Phase 3Results posted
• Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAHCompletedNCT01735617Phase 2Results posted
• Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal HyperplasiaCompletedNCT00519818Phase 1/2Results posted
• Pharmacokinetics, Safety and Tolerability of Crinecerfont in Participants With Congenital Adrenal Hyperplasia Who Are Less Than 2 Years OldActive, not recruitingNCT07187375Phase 2
• Open-label Comparison of Chronocort® Versus Standard Glucocorticoid Replacement TherapyWithdrawnNCT03532022Phase 3
• A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort FormulationsCompletedNCT03051893Phase 1
• An Open Label Study in Healthy Volunteers to Compare Chronocort® to HydrocortisoneCompletedNCT03019614Phase 1
• Safety, Pharmacokinetics and Pharmacodynamics of NBI-77860 in Adolescent Females With Congenital Adrenal HyperplasiaWithdrawnNCT02349503Phase 1