An interventional study of Robot-assisted hand rehabilitation and Motor imagery training in Stroke, Hemiparesis and Activities of Daily Living, sponsored by Uskudar University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-09-01.
Sponsored by Uskudar University · Not applicable, Interventional, and Treatment
Among 484 studies in Stroke with a site in Turkey — 95 open to participants now, 107 under way, 3 of them phase 3. Stroke · Turkey.
Among the 484 studies in Stroke with a site in Turkey, this one is the 150th largest by enrollment of the 320 interventional ones that give a count, is one of 61 that started in 2026, is one of 291 with no phase, and was the 470th registered.
8,255 studies on the registry are indexed under Stroke; 2,056 are open to participants now.
This study's enrollment of 40 is below the median of 49 across 6,024 interventional studies indexed under Stroke.
Browse Stroke studies →95 of the 484 studies in Stroke with a site in Turkey are open now, in 12 countries. Each count lists the studies.
Of the 1,415 Stroke studies recruiting now, 697 (49%) set no upper age limit and 280 (20%) stop at 75 or younger; 77 take children under 18; 196 take healthy volunteers.
This study: 18 Years to 60 Years · all sexes · no healthy volunteers.
The full table on the hub →484 studies; the count open now beside each. This study's row is marked.
First in 1998; this study’s year is marked. 61 started in 2026.
Median enrollment 40 across the 320 interventional studies, 63 across the 164 observational. Of the 338 that completed or were terminated, 22 (7%) have results posted.
29 of 484 have an industry lead sponsor. The 10 most frequent:
Uskudar University is the lead sponsor of 170 studies on the registry; 36 are open to participants now.
Uskudar University has 4 studies filed under Stroke — fewer than ten, so there is no comparison to draw.
35 of the studies in Stroke with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07551141Bitlis Eren UniversityEffects of Plantar Vibration on Gait and Balance in Stroke | 2026-11 |
| NCT07550270Gaziler Physical Medicine and Rehabilitation Education and Research HospitalBody Weight-Supported and Virtual Reality Gait Training in Stroke Patients | 2026-11 |
| NCT06849076Bitlis Eren UniversityThe Influence of Talocrural Manipulation on Proprioception in Stroke | 2026-11-01 |
| NCT07565363Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research HospitalThe Effect of Motor Imagery on Upper Extremity Function in Stroke Rehabilitation | 2026-11-20 |
| NCT06166862Karamanoğlu Mehmetbey UniversityAction Observation and Motor Imagery Therapy in Stroke | 2026-12 |
Among the 484 studies in Stroke with a site in Turkey, from their registry updates:
Loss of upper extremity and particularly hand function after stroke reduces independence in daily activities such as eating, dressing, and personal care. Robot-assisted hand rehabilitation provides repetitive, intensive, and task-oriented practice that supports motor learning, dexterity, and functional hand use. Motor imagery, the mental rehearsal of a movement without physically performing it, is thought to activate motor-related brain networks and to support motor learning and neuroplasticity. Evidence on the added value of combining motor imagery with robot-assisted hand rehabilitation for activities of daily living is limited. This randomized controlled trial will investigate whether motor imagery training added to robot-assisted hand rehabilitation produces greater improvement in activities of daily living than robot-assisted hand rehabilitation alone in individuals with stroke. Forty participants will be randomly allocated to an experimental group (robot-assisted hand rehabilitation plus motor imagery, n=20) or a control group (robot-assisted hand rehabilitation alone, n=20). Both groups will receive the same dose of robot-assisted hand rehabilitation with a soft robotic hand rehabilitation glove, three days per week for six weeks. Outcomes will be assessed at baseline and after the six-week program.
Design and setting This is a two-arm, parallel-group randomized controlled trial conducted at NRL Physical Therapy Medical Center. Institutional permission for the study site has been obtained.
Participants Forty individuals aged 18 years or older with a diagnosis of stroke and impairment of upper extremity and hand function will be enrolled. Written informed consent will be obtained from all participants before any study procedure. Randomization Participants will be allocated 1:1 to the experimental or the control group using a sealed envelope method, resulting in 20 participants per group. Interventions Both groups will receive robot-assisted hand rehabilitation delivered with a soft robotic hand rehabilitation glove (Syrebo). Sessions will be individual, supervised by a physiotherapist, delivered three days per week for six weeks, and will last approximately 40 to 60 minutes each. In addition to robot-assisted hand rehabilitation, participants in the experimental group will perform motor imagery training, in which they will be asked to mentally rehearse hand opening and closing, grasping, object holding, and hand movements used in daily life before physically performing them. Verbal guidance will be provided during motor imagery when needed. The control group will not receive motor imagery training. Attendance will be monitored by the investigator using a session log. Sessions will be terminated in case of pain, excessive fatigue, discomfort, or if the participant does not wish to continue. Outcome assessment Assessments will be performed before the start of the intervention program and repeated after the six-week program is completed. A sociodemographic and clinical information form will record age, sex, education, marital status, occupation, time since stroke, affected side, hand dominance, comorbidities, medications, and previous rehabilitation. Independence in activities of daily living will be assessed with the Barthel Index, hand function related activity limitation with the Duruoz Hand Index, gross manual dexterity with the Box and Block Test, and spasticity of the wrist and finger flexors with the Modified Ashworth Scale. Variables The independent variable is the rehabilitation program (robot-assisted hand rehabilitation alone versus robot-assisted hand rehabilitation plus motor imagery). The dependent variables are the Barthel Index score, the Duruoz Hand Index score, the Box and Block Test score, and the Modified Ashworth Scale grade. Statistical analysis Data will be analysed with SPSS version 23.0. Descriptive statistics will be presented as mean, standard deviation, frequency, and percentage. A p value below 0.05 will be considered statistically significant. Sample size and effect size calculations were performed with G*Power. Ethics and data protection Personal information will be kept confidential, data will be recorded in coded form, and will be used for scientific purposes only. Participants may withdraw at any time. No blood sampling, drug administration, or surgical procedure will be performed.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants receive robot-assisted hand rehabilitation with a soft robotic hand rehabilitation glove, three days per week for six weeks, 40 to 60 minutes per session, plus motor imagery training in which they mentally rehearse hand opening and closing, grasping, object holding, and hand movements used in daily life before physically performing them. Verbal guidance is provided when needed.
Other: Robot-assisted hand rehabilitation · Behavioral: Motor imagery training
Participants receive robot-assisted hand rehabilitation with a soft robotic hand rehabilitation glove at the same frequency, duration, and session length as the experimental group, three days per week for six weeks, 40 to 60 minutes per session, without motor imagery training.
Other: Robot-assisted hand rehabilitation
Individual, physiotherapist-supervised robot-assisted hand rehabilitation delivered with a soft robotic hand rehabilitation glove (Syrebo), providing repetitive task-oriented hand opening, closing, and grasping practice. Three sessions per week for six weeks, approximately 40 to 60 minutes per session.
Mental rehearsal of hand opening and closing, grasping, object holding, and hand movements used in daily life, performed before the corresponding physical movement, with verbal guidance when needed. Delivered in the same sessions as robot-assisted hand rehabilitation, three days per week for six weeks.
Change in independence in activities of daily living (Barthel Index)
The Barthel Index assesses independence in basic activities of daily living including feeding, bathing, grooming, dressing, toilet use, transfers, walking, stair climbing, and bladder and bowel control. Total score ranges from 0 to 100. Higher scores indicate greater independence.
Time frame: Baseline and after the six-week intervention program (week 6)
Plan to share: No — Individual participant data will not be made publicly available. De-identified data supporting the findings may be made available from the corresponding author on reasonable request, subject to institutional approval.
Ran from Jun 2026 to primary completion in Aug 2026, 1 month.
Of 3,108 non-industry interventional studies with no phase under Stroke, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 46. This study's 1 month is below that.
Counting every sponsor, half of 3,252 studies reached it within 23 months; a quarter within 10 and three quarters within 46.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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