An interventional study of Functional Training with SepaRRo and NeuRRoFES in Stroke, sponsored by University of Michigan. Recruiting at 1 site in United States. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by University of Michigan · Not applicable, Interventional, and Device feasibility
Among 22 studies in Stroke by University of Michigan — 3 open to participants now, 3 under way, none of them phase 3. Stroke · University of Michigan.
Among the 22 studies in Stroke by University of Michigan, this one is the 21st largest by planned enrollment of the 21 interventional ones, is the only one that started in 2025, is one of 19 with no phase, and was the 20th registered.
8,255 studies on the registry are indexed under Stroke; 2,056 are open to participants now.
This study's planned enrollment of 4 is below the median of 49 across 6,024 interventional studies indexed under Stroke.
Browse Stroke studies →3 of the 22 studies in Stroke by University of Michigan are open now, in 1 country. Each count lists the studies.
Of the 1,415 Stroke studies recruiting now, 697 (49%) set no upper age limit and 280 (20%) stop at 75 or younger; 77 take children under 18; 196 take healthy volunteers.
This study: 18 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →22 studies; the count open now beside each. This study's row is marked.
First in 2004; this study’s year is marked. 1 started in 2025.
Median enrollment 40 across the 21 interventional studies, 34 across the 1 observational. Of the 19 that completed or were terminated, 12 (63%) have results posted.
University of Michigan is the lead sponsor of 1,506 studies on the registry; 192 are open to participants now.
Of its 169 completed or terminated interventional studies of FDA-regulated products, 133 (79%) have results posted.
1 of the studies in Stroke by University of Michigan that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07218276University of MichiganPassive Robots for Stroke Rehabilitation: A Feasibility Study | 2027-10-01 |
Among the 22 studies in Stroke by University of Michigan, from their registry updates:
The purpose of this study is to examine the feasibility and effectiveness of a novel, multimodal approach that combines passive devices with noninvasive neuromuscular stimulation for upper extremity rehabilitation after stroke.
About 800,000 individuals suffer from a stroke every year in the United States. The majority of stroke survivors often experience lingering deficits in upper extremity function. High-end robotic devices can improve outcomes and clinical productivity; however, these devices are expensive and bulky, making them not practical for many clinical or home environments. This study aims to evaluate the feasibility of low-cost non-motorized devices for stroke rehabilitation in a long-term intervention. The intervention will involve training with a table-top, semi-passive (i.e., no motors) exercise equipment called SepaRRo and commonly-used neuromuscular stimulation. The stimulation will be provided during functional activities using a custom controller (NeuRRoFES) to trigger stimulation. These instruments are designed to provide flexible, compliant assistance/resistance to improve upper extremity function and can be used in a home setting. The study will measure technical feasibility (e.g., qualitative survey, adherence, time on task, retention, ability to perform tasks) as well as clinical feasibility (i.e., changes in biomechanical, neurophysiological, and functional measures) of an intervention with these devices in stroke survivors. The findings aim to support the development of affordable, home-use rehabilitation systems for stroke patients.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive upper extremity rehabilitation using SepaRRo and NeuRRoFES 2-5 times per week for 2-6 weeks
Device: Functional Training with SepaRRo and NeuRRoFES
Participants will perform functional movements (e.g., reach for targets) with their extremities. During movements, the devices will be used to assist or resist their motion. Participants may receive biofeedback of their movements to better engage them in training. Participants may receive assistance from the devices (including neuromuscular stimulation) and/or their less-impaired limb.
Device Survey For Feasibility
Subjective feedback regarding feasibility of the device for training
Time frame: Post-intervention (immediately following last session of intervention)
Retention
Measure of how many participants completed intervention
Time frame: Post-intervention (immediately following last session of intervention)
Adherence
Measure of percentage of sessions completed
Time frame: Post-intervention (immediately following last session of intervention)
Upper extremity Fugl-Meyer Score
Changes in upper extremity Fugl-Meyer score from before the intervention (from baseline) to after its completion using publicly available scoring sheets. The Fugl-Meyer score is a measure of functional impairment and runs from 0 to 66 points, with higher numbers reflecting better outcome.
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively.
Reachable workspace
Changes in reachable workspace from before the intervention (from baseline) to after its completion). The reachable workspace area will be measured with SepaRRo obtained from optical encoders mounted in the device.
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Voluntary hand opening
Changes in voluntary ability to open the hand from before the intervention (from baseline to after its completion). Voluntary hand opening will be measured with motion capture equipment.
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Action Research Arm Test Score
Changes in the Action Research Arm Test Score from before the intervention (from baseline) to after its completion using publicly available scoring sheets. The Action Research Arm Test is a measure of arm functional ability and runs from 0 to 57 points, with higher numbers reflecting better outcome.
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Box and Block (BBT)
Changes in functional measure of arm disability (BBT) from before the intervention (from baseline) to after its completion using publicly available scoring sheets.
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Hand Strength
Changes in force produced by the hand from before the intervention (from baseline) to after its completion as measured by force production recorded with a dynamometer
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Arm strength
Changes in force produced by the arm from before the intervention (from baseline) to after its completion as measured by force production recorded with a dynamometer
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Muscle coordination
Changes in muscle coordination of the upper extremity muscles as measured using surface electromyography between before the intervention (from baseline) to after its completion.
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Joint coordination
Changes in coordination of the upper extremity joints as measured motion capture between before the intervention (from baseline) to after its completion.
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Corticospinal excitability
Changes in corticospinal excitability of the upper extremity muscles as measured using surface electromyography and transcranial magnetic stimulation between before the intervention (from baseline) to after its completion
Time frame: Baseline and post-intervention measurements will be taken on separate days, within a week of the first and last sessions of the intervention, respectively
Plan to share: No
No publications or documents are linked to this record.
Started Nov 2025 (actual). Primary completion is estimated for Oct 2027, 22 months after the start.
Of 3,108 non-industry interventional studies with no phase under Stroke, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 46. This study's planned 22 months is close to that.
Counting every sponsor, half of 3,252 studies reached it within 23 months; a quarter within 10 and three quarters within 46.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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