An interventional study of Placebo Talocrural Joint Manipulation and Talocrural Joint Manipulation in Stroke, sponsored by Bitlis Eren University. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 45 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-07-27.
Sponsored by Bitlis Eren University · Not applicable, Interventional, and Treatment
Among 10 studies in Stroke by Bitlis Eren University — 5 open to participants now, 5 under way, none of them phase 3. Stroke · Bitlis Eren University.
Among the 10 studies in Stroke by Bitlis Eren University, this one is the 10th largest by planned enrollment, is one of 4 that started in 2025, is one of 10 with no phase, and was the 3rd registered.
8,255 studies on the registry are indexed under Stroke; 2,056 are open to participants now.
This study's planned enrollment of 26 is below the median of 49 across 6,024 interventional studies indexed under Stroke.
Browse Stroke studies →5 of the 10 studies in Stroke by Bitlis Eren University are open now, in 1 country. Each count lists the studies.
Of the 1,415 Stroke studies recruiting now, 697 (49%) set no upper age limit and 280 (20%) stop at 75 or younger; 77 take children under 18; 196 take healthy volunteers.
This study: 45 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →10 studies; the count open now beside each. This study's row is marked.
First in 2024; this study’s year is marked. 4 started in 2025.
Median enrollment 44 across the 10 interventional studies. Of the 5 that completed or were terminated, 1 (20%) have results posted.
Bitlis Eren University is the lead sponsor of 51 studies on the registry; 17 are open to participants now.
5 of the studies in Stroke by Bitlis Eren University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07551141Bitlis Eren UniversityEffects of Plantar Vibration on Gait and Balance in Stroke | 2026-11 |
| NCT06849076Bitlis Eren UniversityThe Influence of Talocrural Manipulation on Proprioception in Stroke | 2026-11-01 |
| NCT07612397Bitlis Eren UniversityEffects of Jaw Clenching on Gait and Mobility in Stroke | 2027-01 |
| NCT07619586Bitlis Eren UniversityLumbar Spinal Manipulation in Stroke | 2027-03-15 |
| NCT07898579Bitlis Eren UniversityBeren Vibration Insole in Stroke Rehabilitation | 2027-11-15 |
Among the 10 studies in Stroke by Bitlis Eren University, from their registry updates:
The aim of the study is to investigate the effect of talocrural joint manipulation on the ankle proprioception of patients with stroke.
The study, utilizing a randomized crossover design, is planned to be conducted on a minimum of 26 patients with stroke who meet the inclusion and exclusion criteria. Patients included in the study will be randomly assigned to receive both placebo talocrural joint manipulation and talocrural joint manipulation interventions.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
In this group, patients will receive placebo talocrural joint manipulation. The application will be similar to that in the experimental group, however, hands will be positioned to avoid creating traction or manipulation force, and this position will be maintained for 20 seconds.
Other: Placebo Talocrural Joint Manipulation
In this group, talocrural joint manipulation will be applied. After positioning the patient, high velocity low amplitude traction will be applied.
Other: Talocrural Joint Manipulation
This intervention is a classic method used to evaluate the effect of talocrural joint manipulation.
This technique, aiming to increase ankle dorsiflexion and mechanoreceptor activation, is based on the application of high velocity low amplitude traction to the joint.
Ankle Proprioception
The effect of talocrural joint manipulation on ankle proprioception will be evaluated using the Cybex isokinetic dynamometer. The device will analyze the passive joint position sense of the ankle in various positions.
Time frame: Change from baseline ankle proprioception immediately after the intervention
Ankle Dorsiflexion Measurement
For the measurement of dorsiflexion range of motion, patients will be asked to stand facing a wall with the assessed leg positioned at the back. They will place their hands on the wall at shoulder width. While keeping the back knee in at least 20 degrees of flexion and ensuring the foot remains in contact with the ground, they will be instructed to lean forward as far as possible. The dorsiflexion range of motion will then be measured using a spirit level application on an iPhone placed one centimeter above the calcaneal tuberosity.
Time frame: Change from baseline ankle dorsiflexion immediately after the intervention
Started Apr 2025 (actual). Primary completion is estimated for Nov 2026, 18 months after the start.
Of 3,108 non-industry interventional studies with no phase under Stroke, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 46. This study's planned 18 months is below that.
Counting every sponsor, half of 3,252 studies reached it within 23 months; a quarter within 10 and three quarters within 46.
How these figures are worked out, and which studies are left out of them.
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