An observational study in Stroke, sponsored by Kutahya Health Sciences University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-10-21.
Sponsored by Kutahya Health Sciences University · Observational
This study aims to investigate the impact of cognitive impairment on upper extremity physical performance, cognitive skills, and functional independence in individuals with chronic stroke. A total of 66 chronic stroke survivors will be enrolled and categorized into two groups based on their Montreal Cognitive Assessment (MoCA) scores: the Cognitive Impairment Group (n=33) and the Control Group (n=33). Upper extremity performance, cognitive functions, and functional independence will be comprehensively evaluated using standardized clinical outcome measures.
Background and Rationale:
Cognitive impairment is a frequent and disabling consequence of stroke that can significantly hinder motor recovery, physical performance, and independence in activities of daily living. Although physical rehabilitation predominantly focuses on motor functions, the intricate relationship between cognitive status and upper extremity performance warrants deeper investigation.
Objective:
To examine the effects of cognitive impairment on upper extremity physical performance, specific cognitive domains (attention and working memory), and functional independence in individuals with chronic stroke.
Study Design and Participants:
This cross-sectional comparative study will include 66 volunteer participants with chronic stroke. Participants will be divided into two equal groups (n=33 each) based on a cutoff threshold of the Montreal Cognitive Assessment (MoCA): a Cognitive Impairment Group and a Control Group. Both groups will be matched for age, stroke duration, sex, education level, and affected stroke side.
Assessments \& Outcome Measures:
Upper Extremity Physical Performance: Evaluated using the Wolf Motor Function Test (WMFT), Fugl-Meyer Upper Extremity Assessment (FM-UE), and the Box and Block Test (BBT).
Cognitive Skills: Evaluated using the Stroop Test, Forward Digit Span Test, and Backward Digit Span Test to assess executive functions, attention, and working memory.
Functional Independence: Evaluated using the Functional Independence Measure (FIM), separating motor and cognitive sub-scores.
Significance:
The findings of this study are expected to highlight the critical interaction between cognitive status and upper extremity motor performance in chronic stroke. Consequently, the results will emphasize the necessity of integrating routine cognitive assessments into standard clinical protocols and tailoring stroke rehabilitation programs to address patients' cognitive profiles.
7,441 studies on the registry are indexed under Stroke; 2,012 are open to participants now.
This study's enrollment of 66 is below the median of 160 across 1,729 observational studies indexed under Stroke.
Browse Stroke studies →Kutahya Health Sciences University is the lead sponsor of 216 studies on the registry; 49 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population comprises adult patients of both genders, aged between 18 and 80 years, who have experienced a single ischemic or hemorrhagic stroke at least six months prior to enrollment (chronic stroke phase). Participants are recruited from outpatient physical therapy and rehabilitation clinics. Based on their cognitive screening using the Montreal Cognitive Assessment (MoCA), the study population is categorized into two comparative cohorts: a Cognitive Impairment Group and a Control Group. Eligible participants must be able to communicate effectively, be literate, and have no pre-existing cognitive disorders, severe medical comorbidities, or concurrent neurological/orthopedic conditions that could independently affect physical or cognitive performance.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Scoring 20 or lower on the Montreal Cognitive Assessment (MoCA)
Scoring 21 or higher on the Montreal Cognitive Assessment (MoCA)
Wolf Motor Function Test (WMFT) Performance Time
valuates upper extremity motor ability and functional performance through timed and functional tasks. WMFT performance time is measured in seconds, where longer durations indicate lower performance.
Time frame: Baseline (Single assessment session)
Fugl-Meyer Upper Extremity Assessment (FM-UE) Score
Measures motor recovery, reflex activity, and movement coordination in the upper extremity. Scores range from 0 to 66, with higher scores indicating better motor function.
Time frame: Baseline (Single assessment session)
Box and Block Test (BBT) Score
Assesses unilateral manual dexterity. It measures the number of blocks transported from one compartment to another within 60 seconds (evaluated separately for affected and unaffected upper extremities).
Time frame: Baseline (Single assessment session)
Functional Independence Measure (FIM) Motor and Cognitive Sub-scores
Evaluates the level of independence in activities of daily living. It consists of motor and cognitive sub-scales, where higher scores reflect greater functional independence.
Time frame: Baseline (Single assessment session)
Stroop Test Completion Times
Measures cognitive flexibility, selective attention, and executive functions. Completion times are recorded in seconds, where longer durations indicate greater cognitive impairment.
Time frame: Baseline (Single assessment session)
Forward and Backward Digit Span Test Scores
Evaluates attention, short-term memory, and working memory capacity. Scores are based on the maximum number of digits successfully repeated in forward and backward order
Time frame: Baseline (Single assessment session)
Ran from Jan 2025 to primary completion in Jun 2026, 17 months.
Of 787 non-industry observational studies under Stroke, half reached primary completion within 43 months of starting (the median), counting those still running; a quarter within 18 and three quarters within 101. This study's 17 months is below that.
Counting every sponsor, half of 833 studies reached it within 41 months; a quarter within 18 and three quarters within 92.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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