An interventional study of Cognitive rehabilitation with TERSICORE digital platform in Neurological Disorder, Multiple Sclerosis and Parkinson Disease, sponsored by Istituto per la Ricerca e l'Innovazione Biomedica. Active, not recruiting at 1 site in Italy. Open to participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-06.
Sponsored by Istituto per la Ricerca e l'Innovazione Biomedica · Not applicable, Interventional, and Device feasibility
The main objective of the TERSICORE project is the development of a new advanced set of exergames in the Metaverse that can be used in all clinical and home rehabilitation devices to improve the cognitive therapy of neurological patients by exploiting the potential of social rehabilitation. Five specific exargames will be developed: a) Cooking therapy (Coordinating in a kitchen to complete a dish through shared activities); b) Escape Room (Exiting a simulated room by solving problems and logic puzzles); c) Nostalgia Bits (Sharing personal reminiscence narratives within simulated spaces); d) NeuroTeam (Mindfulness); and e) Truman Show Exploration of an urban space and role-playing.
All exargames will be validated on a small population of neurological patients according to cognitive profile.
974 studies on the registry are indexed under Nervous System Diseases; 252 are open to participants now.
This study's planned enrollment of 25 is below the median of 48 across 623 interventional studies indexed under Nervous System Diseases.
Browse Nervous System Diseases studies →Istituto per la Ricerca e l'Innovazione Biomedica is the lead sponsor of 46 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion criteria for patients:
Acceptability evaluation of TERSICORE digital platform
Device: Cognitive rehabilitation with TERSICORE digital platform
Small groups of end-users will participate in various cognitive tasks carried out in common virtual environments (Metaverse).
Feasibility: Acceptability of Intervention as assessed by TAM3 (Technology Acceptance Model 3) questionnaire.
Number of participants with high level of behavioral intention (TAM3 score range 1-7), with higher scores indicating greater acceptability of intervention.
Time frame: Measured at discharge or 7 days post baseline
Feasibility: Perceived usability of a technological system or application as assessed by SUS (System Usability Scale)
Number of participants with high level of high level of behavioral intention (SUS score range 1-5), high score indicating greater perceived usability of a technological system or application
Time frame: Measured at discharge or 7 days post baseline
Feasibility: User experience of intervention as assessed by UEQ (User Experience Questionnaire)
Number of participants with high level of comprehensive impression of user experience (UEQ score range 1-7), with higher scores indicating greater impression of user experience.
Time frame: Measured at discharge or 7 days post baseline
Feasibility: Intrinsic motivation as assessed by IMI subscale (Intrinsic Motivation Inventory).
Number of participants with high level of behavioral intention (IMI score range 1-7), with higher scores indicating greater intrinsic motivation.
Time frame: Measured at discharge or 7 days post baseline
Feasibility: Sickness elicited by modern virtual reality systems as assessed by SSQ (Simulator Sickness Questionnaire).
Number of subjects with high level of sickness (SSQ score range 0-3), with higher scores indicating greater simulator sickness.
Time frame: Measured at discharge or 7 days post baseline
Language
Changes in phonemic/semantic language ability as assessed by Verbal Fluency
Time frame: Measured at baseline and at the end of the rehabilitation sessions (6 weeks)
Working memory and attention
Changes in executive functioning as assessed by Trial Making Test
Time frame: Measured at before and at the end of the rehabilitation sessions (6 weeks)
Visual-spatial ability
Changes in visual-spatial ability as assessed by Rey Figure
Time frame: Measured at before and at the end of the rehabilitation sessions (6 weeks)
Social metrics
Proximity, frequency of interactions, synchrony and coordination. All these parameters will be measured by sensors
Time frame: Measure recorded during all rehabilitative sessions (6 weeks)
Emotional state
Changes in positive and negative affective states as assessed by Positive and Negative Affect Schedule
Time frame: Measured at baseline and at the end of the rehabilitation sessions (6 weeks)
Social cognition
Changes in theory of mind ability as assessed by Yoni task-48
Time frame: Measured at baseline and at the end the rehabilitation sessions (6 weeks)
Gross manual dexterity level
Changes in gross manual dexterity level as assessed by Box and Block
Time frame: Measured at baseline and at the end the rehabilitation sessions (6 weeks)
Global cognitive functioning
Changes in general cognitive funtioning as assessed by MoCA
Time frame: Measured at baseline and at the end the rehabilitation sessions (6 weeks)
Episodic memory
Changes in episodic memory as assessed by FCRST
Time frame: Measured at baseline and at the end the rehabilitation sessions (6 weeks)
Plan to share: Undecided
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Istituto per la Ricerca e l'Innovazione Biomedica