An observational study in Neurologic Disorder and Subarachnoid Hemorrhage, Aneurysmal, sponsored by BDH-Klinik Hessisch Oldendorf. Recruiting at 1 site in Germany. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-10-01.
Sponsored by BDH-Klinik Hessisch Oldendorf · Observational
Neuropsychological and functional long-term consequences of subarachnoid hemorrhages (SAH) represent a great challenge, since sometimes considerable cognitive deficits occur without evidence of substantial brain damage. In this study, we want to examine if the frequently observed memory deficits are associated with hippocampal atrophy.
Long-term or even permanent neuropsychological impairments are frequently observed after aneurysmal subarachnoid hemorrhages (aSAH). Among the most common impairments after aSAH are memory deficits. Volumetric MRI studies suggest an association of memory dysfunctions with temporal atrophy, especially of the hippocampus. In a previous study, 77 patients with good or moderate clinical outcome after aSAH were examined one year after discharge (Bendel et al., 2006). Temporomesial atrophy was detected without direct brain damage, e.g. by secondary ischemia. Due to the effects of complex cognitive impairments on the quality of life and participation in social and professional life, this relationship will be examined in more detail in the planned study. Specifically, we will investigate to what extent the frequently observed discrepancy between severe memory impairment and normal structural imaging results (no focal lesions in temporomesial areas) is due to hippocampal atrophy. In contrast to Bender and colleagues, this question will be investigated in the acute phase of the disease, immediately after admission to inpatient neurological rehabilitation.
Over a period of 24 months, 29 neurological rehabilitation patients with aSAH (Hunt \& Hess grade I and II) are going to be included. Within the first week (day 1 to 7) after study enrollment, a native MRI examination (without contrast agent) is performed, in which a high-resolution 3D-MPRAGE sequence (T1 weighting) is measured in the sagittal plane. After checking the data quality of the 3D-MPRAGE sequence, especially with regard to its suitability for hippocampal volume determination, a comprehensive neuropsychological examination is performed, in which specific memory and attentional functions are tested.
510 studies on the registry are indexed under Subarachnoid Hemorrhage; 128 are open to participants now.
This study's planned enrollment of 30 is below the median of 120 across 226 observational studies indexed under Subarachnoid Hemorrhage.
Browse Subarachnoid Hemorrhage studies →BDH-Klinik Hessisch Oldendorf is the lead sponsor of 13 studies on the registry; 5 are open to participants now.
Compared within Subarachnoid Hemorrhage, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Nervous System Diseases. The counts are of registry records indexed under each term, refreshed daily. How we classify →
neurological rehabilitation patients with aneurysmal subarachnoid hemorrhage (Hunt \& Hess grade I or II)
Inclusion Criteria:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients undergoing neurological rehabilitation after aneurysmal subarachnoid hemorrhage
Diagnostic Test: Neuropsychological assessment and structural MRI
Healthy adults controlled for age, gender and educational status
Diagnostic Test: Neuropsychological assessment and structural MRI
Complex neuropsychological assessment testing attentional and memory functions. Additionally, a structural MRI is measured.
Changed hippocampal volume in aSAB
Hypothesis: patients have smaller hippocampal volume than healthy control subjects. For the hippocampal volume a structural MRI scan (3D-MPRAGE) is obtained
Time frame: 2 weeks
Changed memory function in aSAB
Hypothesis: patients have lower scores in the Visual and Verbal memory test (VVM) than healthy control subjects.
Time frame: 2 weeks
Influence of the type of therapy on the hippocampal volume
Hypothesis: hippocampal volumes differ between aSAH patients with surgical or endovascular treatment.
Time frame: 2 weeks
Influence of the lesion site on the hippocampal volume
Hypothesis: there are no differences between ispi- and contralateral hippocampal volumes
Time frame: 2 weeks
Interrater reliability
Hypothesis: It is expected that there will be no difference in the ratings of hippocampal volume between two independent raters.
Time frame: 2 weeks
Changed intracranial volume in aSAB
Hypothesis: patients have smaller intracranial volume than healthy control subjects.
Time frame: 2 weeks
Plan to share: Yes — All IPD that underlie results in a publication.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: Period of availability begins when results are published, at the earliest in Dec 2022
Access criteria: IPD can be obtained from the principal investigator upon reasonable request.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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