An observational study in Periodontal Diseases, sponsored by Universidad Complutense de Madrid. Recruiting at 2 sites in Spain. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-29.
Sponsored by Universidad Complutense de Madrid · Observational
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Among 26 studies in Periodontal Diseases with a site in Spain — 10 open to participants now, 10 under way, none of them phase 3. Periodontal Diseases · Spain.
Among the 26 studies in Periodontal Diseases with a site in Spain, this one is one of 2 that started in 2025, is one of 8 observational ones, and was the 22nd registered.
867 studies on the registry are indexed under Periodontal Diseases; 189 are open to participants now.
Browse Periodontal Diseases studies →10 of the 26 studies in Periodontal Diseases with a site in Spain are open now. Recruiting first, the newest first:
Universidad de Murcia · Sites in Spain
Ages 18–40
Universidad Complutense de Madrid · Sites in Spain
Ages 18+ · Healthy volunteers
Aesculap AG · Sites in Spain
Ages 18+
Universidad de Murcia · Sites in Spain
Ages 18–80
University of Barcelona · Sites in Spain
Ages 18+ · Healthy volunteers
A study can be open while its sites in Spain have not opened yet or have stopped. Only those recruiting at a site in Spain →
Of the 101 Periodontal Diseases studies recruiting now, 47 (47%) set no upper age limit and 42 (42%) stop at 75 or younger; 5 take children under 18; 58 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
26 studies; the count open now beside each. This study's row is marked.
First in 2012; this study’s year is marked. 2 started in 2025.
This study's planned enrollment of 100 is close to the median of 99 across 302 observational studies indexed under Periodontal Diseases.
Median enrollment 29 across the 18 interventional studies, 97 across the 8 observational. Of the 14 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
2 of 26 have an industry lead sponsor. The 10 most frequent:
Universidad Complutense de Madrid is the lead sponsor of 206 studies on the registry; 64 are open to participants now.
Universidad Complutense de Madrid has 5 studies filed under Periodontal Diseases — fewer than ten, so there is no comparison to draw.
5 of the studies in Periodontal Diseases with a site in Spain that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05813236Aesculap AGNOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery | 2026-11 |
| NCT03997552Universidad de MurciaNIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration | 2026-12-01 |
| NCT05533528Universidad de MurciaPeriodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment | 2026-12-22 |
| NCT07718061Universidad de MurciaBacterial Diversity Study Using 16S rRNA Sequencing of Periodontal Samples From Patients With Orthodontic Retainers | 2027-07 |
| NCT07167771Universidad Complutense de MadridLONGITUDINAL FOLLOW-UP STUDY TO DETERMINE THE PREDICTIVE ABILITY OF A PANEL OF BIOMARKERS IN SALIVA IN HEALTHY AND PERIODONTALLY AFFECTED PATIENTS | 2027-10 |
Add all 5 to your calendar (.ics) → With an account.
Among the 26 studies in Periodontal Diseases with a site in Spain, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Objective: The main aim of this longitudinal clinical study is to evaluate the predictive ability of a panel of salivary biomarkers in determining periodontal health status in 2 years follow up in a group of healthy and periodontally affected individuals.
Material and methods: In this longitudinal, observational follow-up study, patients previously enrolled in a cross-sectional study at the Periodontal Postgraduate Clinic, University Complutense of Madrid, will be re-evaluated over a 2-year period. Participants (≥18 years) will be categorized into diagnostic groups based on the 2018 classification of periodontal diseases, including periodontally healthy, gingivitis, treated periodontitis (stable/unstable), and various stages of periodontitis. The study will include follow-up visits at 1 and 2 years. At each visit, participants will undergo a comprehensive medical examination to assess age, gender, weight, height, waist circumference, blood pressure, temperature, smoking and alcohol history, systemic health, and HbA1c levels. A periodontal examination will be performed at six sites per tooth, and clinical parameters including plaque, bleeding on probing, probing depth, recession, and tooth loss will be recorded. Saliva and subgingival plaque samples will be collected for biomarker and microbiological analysis. Salivary biomarkers will be measured using multiplex immunoassays, and bacterial quantification will be performed by multiplex qPCR. Data analyses: Descriptive statistics will be used to report the clinical variables and patients will be grouped according to the pre-established diagnostic categories (periodontally healthy, gingivitis, treated periodontitis patient. In order to determine the possible statistical relationship with the medical, biochemical and microbiological variables assessed, a crude bivariate analysis will first be performed by applying a mean comparison test for quantitative variables (ANOVA) and a proportion comparison test for categorical variables (Chi-square). Subsequently, those variables identified as relevant in the crude analyses will be included as confounding and/or interaction factors in a binary logistic regression model, considering the presence of periodontitis as a response variable, in order to obtain crude and adjusted OR values, together with their corresponding 95% CIs. Based on the results obtained in the biomarker analysis, a relevant statistical analysis will be performed, taking into account all the variables collected in the study. For periodontitis cases, treatment response over time will be analyzed, with subgroup comparisons between responders and non-responders.
This study will be conducted as a 2y longitudinal, observational follow-up study, from a previous cross-sectional study (code 23/481-E). The study will be conducted at the Faculty of Dentistry University Complutense of Madrid, Spain. The research group and facilities associated with the university will serve as the primary study setting for participant recruitment, data collection, and analysis.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants involved in an already done cross-sectional study (code 23/481-E).
Other: No intervention
There is not intervention in these patients, appart from their normal dental check-up visits.
Salivary biomarkers
Concentrations of specific biomarkers (IL-1 and MMP-8) analyzed using multiplex commercial diagnostic tests.
Time frame: Baseline, 1 and 2 years
Age
Participant's age in years.
Time frame: Baseline, 1 and 2 years
Gender
Gender
Time frame: Baseline, 1 and 2 years
Weight
Weight (kg)
Time frame: Baseline, 1 and 2 years
Height
Height (cm)
Time frame: Baseline, 1 and 2 years
Waist circumference
A measuring tape will be used, and the determination will be made above the hip bone
Time frame: Baseline, 1 and 2 years
HbA1c
Following the instructions from the manufacturer of the device (A1CNow+; Bayer) and diabetic risk questionnaire (Finn-risk)
Time frame: Baseline, 1 and 2 years
Blood pressure
The procedure will follow the recommendations in the clinical practice guidelines of the American Heart Association (AHA) {Whelton, 2018 #466}. In summary, a validated and approved blood pressure monitor (Omron M6 COMFORT IT HEM-7322U-E) will be used with the patient seated, back straight, and arms supported at heart level. After the initial measurement, there will be a 5-minute rest period before taking a second reading. The average of the two readings will be considered valid.
Time frame: Baseline, 1 and 2 years
Temperature
Participant's body temperature in degrees Celsius.
Time frame: Baseline, 1 and 2 years
Drug, alcohol, and smoking history
History of participant's drug, alcohol, and smoking habits.
Time frame: Baseline, 1 and 2 years
Nicotine dependency
Assessment of nicotine dependency using the Fagerström Test for Nicotine Dependence.
Time frame: Baseline, 1 and 2 years
Health anamnesis
Relevant systemic health information collected through a complete health history questionnaire
Time frame: Baseline, 1 and 2 years
Presence and quantification of specific periodontal pathogens
P. gingivalis, A. actinomycetemcomitans, T. forsythia detected through real time PCR analysis
Time frame: Baseline, 1 and 2 years
Plaque index
categorized as presence/absence
Time frame: Baseline, 1 and 2 years
Bleeding on probing
assessed dichotomously within 15 seconds after probing
Time frame: Baseline, 1 and 2 years
Suppuration on probing
assessed dichotomously within 15 seconds after probing
Time frame: Baseline, 1 and 2 years
Probing depth
defined as the distance in mm between the bottom of the pocket and the gingival margin
Time frame: Baseline, 1 and 2 years
Recession
defined as the distance in mm between the amelocemental boundary and the gingival margin. The sum of probing depth and recession will determine the patient's clinical attachment loss
Time frame: Baseline, 1 and 2 years
Number of teeth lost and reason
Number of teeth lost and reason
Time frame: Baseline, 1 and 2 years
Plan to share: No
No publications or documents are linked to this record.
Started Oct 2025 (actual). Primary completion is estimated for Oct 2027, 24 months after the start.
Of 79 non-industry observational studies under Periodontal Diseases, half reached primary completion within 13 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's planned 24 months is above that.
Counting every sponsor, half of 83 studies reached it within 13 months; a quarter within 7 and three quarters within 32.
How these figures are worked out, and which studies are left out of them.
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Universidad Complutense de Madrid →