An interventional study of periodontal surgery in Periodontal Pocket, Periodontal Diseases and Periodontal Bone Loss, sponsored by Universidad de Murcia. Recruiting at 1 site in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-19.
Sponsored by Universidad de Murcia · Not applicable, Interventional, and Treatment
The objective of this study will be to evaluate a new protocol for the surgical treatment of periodontal disease with two novelties: to make a single incision in the midline of the interproximal area to respect the vascular supply and preserve the granulation tissue with regenerative potential.
The investigators will carry out a controlled and randomized clinical trial with a control group (n=25; modified Kirkland flap) and a test group (n=25; experimental surgical protocol: incision in the mid-interproximal area of the papilla and preservation of the granulation tissue).
Clinical parameters will be taken at the time of surgery and 12 months follow-up: bleeding on probing (BoP), clinical attachment level (CAL), residual probing depth (rPD),Probing pocket depth reduction (PPDr), recession (REC), interproximal gingival recession (iGR), width of keratinized gingiva (KT), gain of supra-alveolar clinical attachment (SUPRA-AG), early wound healing index (EHI).
126 studies on the registry are indexed under Periodontal Pocket; 36 are open to participants now.
This study's planned enrollment of 25 is below the median of 30 across 109 interventional studies indexed under Periodontal Pocket.
Browse Periodontal Pocket studies →Universidad de Murcia is the lead sponsor of 77 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Access flap periodontal surgery
Procedure: periodontal surgery
Access flap periodontal surgery and periodontal granulation tissue debridement.
Procedure: periodontal surgery
A sulcular incision will be made in the affected teeth, followed by an incision from the buccal aspect in the mid-portion of the interproximal tissues The buccal and lingual flaps will be elevated. For periodontal granulation tissue preservation group, the soft tissues covering the alveolar crest will be prepared. A third incision will separate the pocket epithelium from the soft tissue (granulation tissue) attached to the bone. The pocket epithelium will be removed. The root surfaces will be carefully scaled and planed in both groups. Ethylenediaminetetraacetic acid (24%) will be applied to the root surfaces and removed after 2 minutes with abundant saline solution. In the experimental group, the preserved attached soft tissue and the space between it and the root surface will be irrigated with 10% polyvinylpyrrolidone-iodine. Finally, the flaps will be positioned and sutured.
Clinical attachment gain (CAG)
Clinical attachment gain
Time frame: 12 months
rPD
residual probing depth
Time frame: 12 months
PPDr
Probing pocket depth reduction
Time frame: 12 months
iGR
interproximal gingival recession
Time frame: 12 months
Early Healing Index (EHI)
Five types of early healing will be recorded: EHI 1, complete closure of the incision line, with no fibrin; EHI 2-3, formation of a thin line or a fibrin clot in the incision area, respectively; EHI 4-5, incomplete closure with partial necrosis or necrosis of the incision area, respectively.
Time frame: 1 week
SUPRA-AG
Supra-alveolar attachment gain
Time frame: 12 months
Plan to share: No
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Universidad de Murcia