CClinicalTrials.gg
Active, not recruitingNCT06270693Updated Feb 21, 2024

hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis

An interventional study of Endodontic treatment in Apical Periodontitis and Coronary Artery Disease, sponsored by Postgraduate Institute of Dental Sciences Rohtak. Active, not recruiting at 1 site in India. Open to participants aged 40 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-02-21.

Sponsored by Postgraduate Institute of Dental Sciences Rohtak · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 1 year 2 months after the study started (first participant enrolled Nov 2022, registered Jan 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
70
Allocation
Non-randomized
Ages
40 Years to 75 Years
Sex
All
01

Study summary

Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary Artery Disease without chronic pulp exposure.

Read the detailed description

Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary Artery Disease without chronic pulp exposure. Systemic inflammatory burden is assessed before and after endodontic treatment.

02

Conditions studied

  • Apical Periodontitis
  • Coronary Artery Disease

Keywords

  • apical periodontitis
  • coronary artery disease
03

In context

Periodontitis

1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.

This study's enrollment of 70 is above the median of 45 across 1,191 interventional studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

Postgraduate Institute of Dental Sciences Rohtak is the lead sponsor of 209 studies on the registry; 71 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Coronary artery disease patients with and without chronic pulp exposure

Exclusion criteria

Exclusion Criteria:

  • Other systemic diseases
  • Antibiotics for More than 1 month
  • Smoking
  • Analgesics more than 1 week
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
70 participants (actual)

Study arms

  • Experimental
    CAD WITH AP

    CORONARY ARTERY DISEASE WITH APICAL PERIODONTITIS

    Procedure: Endodontic treatment

  • No intervention
    CAD WITHOUT AP

    CORONARY ARTERY DISEASE WITHOUT AP

Interventions

  • ProcedureEndodontic treatment

    Root canal treatment

06

What researchers measure

Primary outcomes

  1. Serum hsCRP

    Systemic inflammatory burden assessed

    Time frame: 12 months

  2. complete hemogram indices

    Systemic inflammatory burden assessed

    Time frame: 12 months

Secondary outcomes

  1. Periapical index SCORE CHANGE

    1-5 ordinal scale,5 worse outconpme \& HEALING ASSESSED

    Time frame: 12 months

07

Study locations

1 site
  • PGIDS
    Rohtak, Haryana 124001, India
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 21, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06270693
Lead sponsor
Postgraduate Institute of Dental Sciences Rohtak
Responsible party
Sponsor
First posted
Feb 21, 2024
Start date
Nov 1, 2022
Primary completion
Feb 1, 2024
Completion
Apr 1, 2024 (estimated)
Last update
Feb 21, 2024

Study contacts

DR SANJAY TEWARI, MDS
study director · Post Graduate Institute Of Dental Sciences,Rohtak

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion