An interventional study of Hypoxia and/or Exercise in Hypoxia, Cerebral Hypoxia and Brain Diseases, sponsored by University Hospital, Grenoble. Recruiting at 1 site in France. Open to participants aged 60 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-08.
Sponsored by University Hospital, Grenoble · Not applicable, Interventional, and Prevention
In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional capacities and a sufficient quality of life in the elderly. The alteration of vascular function (at the cerebral and systemic level) with aging is an important feature in the clinical picture including a decrease in physical and cognitive capacities. Although physical activity is recognized as an essential means of combating the effects of aging, optimizing its effects by defining the most effective strategies of practice remains a key objective. Offering alternative interventions to exercise training is also necessary for people who are unwilling or unable to engage in a physical activity program. In this context, hypoxic conditioning, alone or in conjunction with rehabilitative exercise training, is a new therapeutic modality with strong preclinical validity, in particular from a cardiovascular standpoint, and used in other pathologies to improve cardiovascular function and exercise performance and quality of life. Our aim is, therefore, to investigate the effect of hypoxic conditioning (alone or in conjunction with exercise training) on cerebrovascular health in the elderly.
81 studies on the registry are indexed under Hypoxia, Brain; 19 are open to participants now.
This study's planned enrollment of 64 is close to the median of 60 across 55 interventional studies indexed under Hypoxia, Brain.
Browse Hypoxia, Brain studies →University Hospital, Grenoble is the lead sponsor of 837 studies on the registry; 207 are open to participants now.
Compared within Hypoxia, Brain, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Hypoxia. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Sessions of intermittent hypoxia at rest; 3 sessions/week; 8 weeks. To be compared with the placebo (normoxia) group at rest.
Procedure: Hypoxia and/or Exercise
Sessions of normoxia at rest; 3 sessions/week; 8 weeks.
Procedure: Hypoxia and/or Exercise
Sessions of exercise training under hypoxia; 3 sessions/week; 8 weeks. To be compared with the placebo (exercise under normoxia) group.
Procedure: Hypoxia and/or Exercise
Sessions of exercise training under hypoxia; 3 sessions/week; 8 weeks.
Procedure: Hypoxia and/or Exercise
Hypoxia at rest versus normoxia at rest; Hypoxia during exercise versus Normoxia during exercise.
Middle cerebral artery flow velocity
Changes in middle cerebral artery flow velocity in response to hypercapnia (5% CO2)
Time frame: Before intervention; right after intervention; 2 months after intervention
Peak oxygen uptake
Peak oxygen uptake during a cardiopulmonary exercise test
Time frame: Before intervention; right after intervention; 2 months after intervention
Flow-mediated dilation
Flow-mediated dilation in response to ischemia-reperfusion of the brachial artery
Time frame: Before intervention; right after intervention; 2 months after intervention
Blood pressure
24h (systolic, diastolic and mean) blood pressure assessment
Time frame: Before intervention; right after intervention; 2 months after intervention
Sleep
Sleep features assessed by polygraphy
Time frame: Before intervention; right after intervention; 2 months after intervention
Cognitive function
Cognitive function assessed by the Montreal Cognitive Assessment questionnaire
Time frame: Before intervention; right after intervention; 2 months after intervention
Health-related quality of life
Health-related quality of life assessed by the SF-36 questionnaire
Time frame: Before intervention; right after intervention; 2 months after intervention
Plan to share: No — No plan at this point in time.
No publications or documents are linked to this record.
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