An observational study in Healthy Adult Participants, sponsored by University Hospital, Grenoble. Not yet recruiting at 1 site in France. Open to participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by University Hospital, Grenoble · Observational
For safety considerations and to ensure the effectiveness of physical activity within a rehabilitation programme, it is important to establish an appropriate exercise intensity to achieve the programme's objectives. This requires identifying individualised exercise intensity zones that are specifically tailored to each patient, in order to design an effective and progressive exercise training programme.
Exercise prescription is based on four principles: frequency, duration, volume, and intensity. The first three factors are relatively easy to adjust when planning a training programme, whereas exercise intensity is based on a concept that is more difficult to assess and control. On the one hand, exercise intensity is more complex to measure; on the other, establishing individualised reference points and guidelines tailored to each patient is not straightforward.
It is now well established that ventilatory transitions are individualised physiological markers that delineate exercise intensity zones. These transition markers provide valuable reference points for exercise training, helping to ensure that physical activity is both safe and sufficiently intense to induce beneficial physiological adaptations in patients.
Within this rehabilitation context, the aim of the present study is to identify markers of these two physiological transitions during a maximal exercise test conducted under laboratory conditions. The study seeks to identify non-invasive markers related to cardiovascular, respiratory, and motor responses, with a view to conducting similar assessments under real-world conditions in the future. A database has already been established using cycle ergometry (the CAREMO protocol). The next step is to build a new database based on maximal exercise testing, this time using two different exercise modalities: the elliptical trainer and the treadmill. In addition to the new challenge of investigating the second ventilatory transition, the less constrained movement patterns associated with these exercise modalities require adaptations to the analysis methods in order to continue identifying changes in motor behaviour.
There are currently no accessible physiological datasets combining synchronised motor data (motion analysis) and cardiorespiratory data (ECG, gas exchange analysis, and spirometry) in humans during exercise on an elliptical trainer or a treadmill.
The work conducted as part of this study will focus on acquiring data from wearable inertial measurement units (IMUs) to assess motor behaviour, cardiac measurements, and laboratory measurements required to determine the first and second ventilatory thresholds (VT1 and VT2) using gas exchange analysis, across both exercise modalities.
To this end, 20 participants will take part in two sessions involving a maximal incremental exercise test. The two sessions will be scheduled between one and fifteen days apart. The first session will involve exercise on a treadmill, while the second will involve exercise on an elliptical trainer.
The signals recorded during the study may contribute to a better understanding of the relationship between cardiorespiratory physiology and motor behaviour during exercise.
For example, as outlined in the secondary objectives of the study, these signals may be used to develop new algorithms for defining criteria to assess motor transitions.
The following hypotheses will be investigated:
University Hospital, Grenoble is the lead sponsor of 837 studies on the registry; 207 are open to participants now.
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Healthy volunteers
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Treadmill · Other: Elliptical bike
Incremental exercise tests on treadmill
Incremental exercise tests on elliptical bike
Inertial Measurement Units
Measured with Inertial Measurement Units (IMU), placed on the pelvis, the thighs and the shanks. Time series collected at 60Hz, with 3 axis Accelerations (m/s²), 3 axis Gyroscops (rad/s) Data are timestamped and synchronized with the world clock
Time frame: 20 minutes of exercise test
Gas Analysis
Gas analyser measurements, (VO2 (L/min), VCO2 (L/min), PetO2 (mmHg), PetCO2 (mmHg), VE (L/min) Measures are timestamped, and saved breath-by-breath Data are timestamped and synchronized with the world clock
Time frame: 20 minutes of exercise test
Rate of Perceived Exertion (RPE)
RPE, also named BORG scale rates perceived exertion on a scale from 6 to 20. 1 measurement per min Data are timestamped and synchronized with the world clock
Time frame: 20 minutes of exercise test
Ergometer
Running Treadmill, or Elliptical bike Data collected are the following (1Hz): Cadence, Human Power or Speed Data are timestamped and synchronized with the world clock
Time frame: 20 minutes of exercise test
Plan to share: Undecided
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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