An interventional study of Imageless computer-navigated THA surgery and Standard of care THA surgery in Total Hip Arthroplasty and Computer-Assisted Surgery, sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. Recruiting at 1 site in Canada. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-10-07.
Sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Not applicable, Interventional, and Treatment
Replacing diseased hip joints with prosthetic implants in a procedure called total hip arthroplasty (THA) is associated with high rates of patient satisfaction, pain relief, and functional improvement when the implant is appropriately placed. Incorrect implant size or placement may lead to a breadth of negative outcomes, which could result in the need for implant revision. It is difficult to assess the precise orientation of patient hips on the operating table, with one study revealing that only 26% of acetabular cups placed without technological assistance are correctly positioned. Using computer navigation as a guide to achieve optimal implant alignment may improve successful placement rates. The additional incorporation of real-time modeling software may further help realize higher rates of successful implant placement. This study, therefore, aims to investigate a computer navigation system coupled with real-time modeling software to establish the benefit of such technology in the operating room, and further improve positive patient outcomes following THA. We hypothesize that including technological assistance in THAs will yield better patient outcomes compared to surgeries performed freehand.
2,974 studies on the registry are indexed under Osteoarthritis; 438 are open to participants now.
This study's planned enrollment of 180 is above the median of 80 across 2,240 interventional studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's is the lead sponsor of 331 studies on the registry; 137 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The criteria were revised on the registry on Oct 7, 2026. See what changed
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients in this arm will receive standard patient of care implants but imageless navigation software will be used to plan optimal acetabular cup placement.
Procedure: Imageless computer-navigated THA surgery
Patients in this arm will receive standard of care implants and undergo standard of care procedure for total hip arthroplasty.
Procedure: Standard of care THA surgery
Patients in this arm will receive standard patient of care implants but computer navigation software will be used to plan optimal acetabular cup placement.
Procedure: CT-based Computer-navigated THA surgery
Navigation software coupled with real-time modeling software will be used to plan optimal acetabular cup for patients undergoing THA.
Patients already underwent THA procedure with manual placement of acetabular cup with conventional instrumentation.
CT- based computer navigation software coupled with modeling software will be used to plan optimal acetabular cup for patients undergoing THA.
Acetabular cup position
CT examination. Measuring acetabular cup inclination and anteversion in degrees.
Time frame: 6 months post-op
Protrusion length
CT examination. Length of protrusion in the sagittal and axial view.
Time frame: 6 months post-op
Acetabular cup loosening
CT examination. Presence od acetabular cup loosening, indicated by periprosthetic radiolucency \> 2 mm in width.
Time frame: 6 months post-op
Degree of heterotopic ossification
CT examination. Classification of heterotopic ossification based on Brooker Classification.
Time frame: 6 months post-op
Muscle area
CT examination measuring muscle cross-sectional area (in mm2).
Time frame: 6 months post-op
Muscle density
CT examination measuring radiological density (in HU).
Time frame: 6 months post-op
Capsular scarring
MRI examination. Measuring the joint capsule in its thickest part.
Time frame: 6 months post-op
Joint effusion.
MRI examination. Grading according to Mitchel et al. 1986
Time frame: 6 months post-op
Quantification of fluid.
MRI examination. Grading according to Mitchel et al. 1986
Time frame: 6 months post-op
Heterotopic ossification in periarticular soft tissues.
MRI examination. Classification of heterotopic ossification based on Brooker Classification.
Time frame: 6 months post-op
Soft tissue impingement
MRI examination. Measuring acetabular angle of anteversion.
Time frame: 6 months post-op
Integrity of the periarticular muscles.
MRI examination. Grading based on the Goutallier classification.
Time frame: 6 months post-op
Oxford Hip Score
Joint-specific patient-reported outcome measure of disability in patients following THA
Time frame: 3- and 6-months post-op
UCLA Activity Score
Validated 10-point scale evaluating patient activity levels
Time frame: 3- and 6-months post-op
VR-12
Patient-reported outcome measure of patient's overall perspective of their health
Time frame: 3- and 6-months post-op
WOMAC questionnaire
Self-administered questionnaire assessing activities of daily living, functional mobility, gait, general health and quality of life.
Time frame: 3- and 6-months post-op
Novel questionnaire
Self-reported outcome measure that assess the patient's ability to perform 10 common activities of daily living (gait, pivot left, pivot right, upstairs, downstairs, step over, chair sit/rise, bend forward, sit low, and squat)
Time frame: 3- and 6-months post-op
Harris Hip Score
A measure of dysfunction following total hip arthroplasty
Time frame: 3- and 6-months post-op
Plan to share: No
No publications or documents are linked to this record.
Started Aug 2022 (actual). Primary completion is estimated for Nov 2027, 63 months after the start.
Of 578 non-industry interventional studies with no phase under Osteoarthritis, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 52. This study's planned 63 months is above that.
Counting every sponsor, half of 713 studies reached it within 29 months; a quarter within 11 and three quarters within 58.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's →