An interventional study of Wearable-Monitored Workplace Exercise Program and Educational Session and Sitting Self-Monitoring in Office Workers, sponsored by Mahidol University. Not yet recruiting. Open to participants aged 20 Years to 59 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-09.
Sponsored by Mahidol University · Not applicable, Interventional, and Other
This study aims to investigate the effects of a 12-week wearable-monitored workplace exercise program on physical performance, brain activity, and biological markers in office workers.
Prolonged sitting is common among office workers and may negatively affect physical health and well-being. This study will examine whether incorporating regular, technology-assisted exercise breaks into the workday can improve physical performance and produce measurable changes in brain activity and proteins found in blood and sweat.
A total of 78 Thai office workers aged 20-59 years will participate in this study. Participants will be classified according to their habitual physical activity levels into active and sedentary office workers. The 26 active office workers will continue their usual physical activity habits and serve as an active control group. The 52 sedentary office workers will be randomly allocated into two groups: a self-monitoring control group (26 participants) and an experimental group (26 participants).
The self-monitoring control group will receive educational information about the health benefits of reducing prolonged sitting and will use a logbook to monitor their sitting behaviors while maintaining their usual daily routines. The experimental group will participate in a 12-week wearable-monitored workplace exercise program using an intelligent wearable device and a gamified smartphone application. The system provides exercise prompts, real-time feedback, and personalized guidance to encourage participants to perform short exercise sessions during their workday, with a target of at least 150 minutes of exercise per week.
All participants will undergo assessments before and after the intervention. These assessments will evaluate physical performance, muscle strength, movement characteristics, cortical excitability and inhibition using transcranial magnetic stimulation (TMS), and biological markers obtained from blood and sweat samples. Additional assessments will include body composition, physical activity levels, musculoskeletal discomfort, and the usability and acceptability of the exercise system.
The study will compare changes in these measurements among the three groups to determine the effects of the wearable-monitored workplace exercise program and explore its potential benefits for improving physical performance, neurological function, and exercise-related biological responses in office workers.
9,798 studies on the registry are indexed under Motor Activity; 1,910 are open to participants now.
This study's planned enrollment of 78 is above the median of 60 across 8,388 interventional studies indexed under Motor Activity.
Browse Motor Activity studies →Mahidol University is the lead sponsor of 747 studies on the registry; 119 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Metallic implants, stents, or pacemakers in any part of the body. History of epilepsy or seizure disorders. History of unexplained fainting. History of traumatic brain injury or previous brain trauma.
- Contraindications to sauna bathing, including: Cardiovascular conditions, such as myocardial ischemia, congestive heart failure, cardiac arrhythmias, uncontrolled hypertension (systolic blood pressure >160 mmHg), or resting tachycardia (>100 beats/minute).
History of dermatological conditions, such as psoriasis. History of unexplained chest pain. Pregnancy.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants are physically active office workers who already meet the recommended physical activity levels. They will maintain their habitual physical activity and usual daily routines throughout the 12-week study period without receiving a specific study exercise intervention.
Sedentary office workers will receive an educational session about the health benefits of reducing and interrupting prolonged sitting. They will use a sitting diary or logbook to monitor their sedentary behavior while maintaining their usual daily routines throughout the 12-week study period.
Behavioral: Educational Session and Sitting Self-Monitoring
Sedentary office workers will participate in a 12-week wearable-monitored workplace exercise program using the Intelligent Health Promotion Service System (IHPSS). The system integrates wearable surface electromyography (sEMG) sensors, a six-axis inertial measurement unit (IMU), and a gamified smartphone application to provide physiological feedback, exercise prompts, and personalized guidance. Participants will perform 5-minute exercise sessions following approximately every 60 minutes of work, targeting at least 150 minutes of exercise per week. Exercise performance will be monitored and adjusted according to movement quality and individual performance.
Behavioral: Wearable-Monitored Workplace Exercise Program
A 12-week workplace exercise intervention using the Intelligent Health Promotion Service System (IHPSS), an integrated platform combining wearable surface electromyography (sEMG) sensors, a six-axis inertial measurement unit (IMU), and a gamified smartphone application. Participants receive automated auditory and haptic notifications after approximately every 60 minutes of work to perform 5-minute exercise sessions. The daily schedule is repeated for approximately 6-8 hours per day, 4-5 days per week, targeting at least 150 minutes of exercise per week. The system provides real-time muscle activation feedback, movement monitoring, personalized exercise guidance, and performance-based progression.
An educational session providing information about the health benefits of reducing and interrupting prolonged sitting, accompanied by a sitting diary or logbook for monitoring sedentary behavior throughout the 12-week study period.
Resting and Active Motor Thresholds (RMT and AMT) Copy
Resting motor threshold (RMT) and active motor threshold (AMT) are assessed using transcranial magnetic stimulation (TMS) and recorded as the percentage of maximum stimulator output required to elicit a motor-evoked potential (MEP). RMT is measured during muscle relaxation, while AMT is measured during a 10-20% maximum voluntary contraction.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Cortical Silent Period (CSP)
Cortical silent period duration is measured in milliseconds using TMS during sustained muscle contraction. CSP is determined from the interval between the end of the MEP response and the recovery of rectified electromyographic activity to the predefined baseline level.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Short-Interval Intracortical Inhibition (SICI) and Intracortical Facilitation (ICF)
Intracortical inhibition and facilitation are assessed using paired-pulse TMS. The ratio of conditioned to unconditioned MEP amplitudes is calculated. SICI is measured at interstimulus intervals of 1, 2, 3, and 5 ms, while ICF is measured at 8, 10, 12, and 15 ms.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Motor-Evoked Potential Input/Output Curve
Corticospinal excitability is assessed by recording MEP amplitudes across TMS stimulus intensities ranging from 90% to 150% of resting motor threshold in 10% increments. Mean peak-to-peak MEP amplitudes are calculated and fitted using a Boltzmann sigmoid function to estimate the plateau amplitude.
Time frame: Baseline (Week 0) and post-intervention (Week 13).
Plasma and Sweat Extracellular Vesicle Concentration
Extracellular vesicles isolated from plasma and sweat samples are quantified using nanoparticle tracking analysis (NTA). Vesicle concentration is reported as particles per milliliter (particles/mL).
Time frame: Baseline (Week 0) and post-intervention (Week 13).
Plasma and Sweat Extracellular Vesicle Size Distribution
Extracellular vesicle size distribution in plasma and sweat samples is assessed using nanoparticle tracking analysis. The modal vesicle diameter is reported in nanometers, together with the proportion of particles within the 30-150 nm size range.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Proteomic Cargo of Plasma and Sweat Extracellular Vesicles
Protein cargo in plasma and sweat extracellular vesicles is characterized using high-throughput mass spectrometry. Protein profiles are reported as relative protein abundance or presence/absence. Protein identification and functional interpretation are performed using the UniProt human proteome and STRING protein-protein interaction and pathway analyses.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Quadriceps Isokinetic Strength
Quadriceps muscle strength is assessed as peak torque during concentric knee extension at angular velocities of 60, 180, and 300 degrees per second. The highest torque across maximal repetitions at each speed is recorded in Newton-meters (Nm).
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Shoulder Isokinetic Strength
Shoulder muscle strength is assessed as peak torque during concentric shoulder through a range of motion of 0-150 degrees at angular velocities of 60 and 120 degrees per second. Peak torque is reported in Newton-meters (Nm).
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Isometric Handgrip Strength
Maximum voluntary isometric handgrip force of the dominant hand is measured. The highest value from three trials is recorded in kilograms (kg) or converted to Newtons (N).
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Time to Peak Hand Velocity
Hand movement cycles are identified using hand-marker trajectories. Peak resultant hand velocity is determined within each movement cycle, and the time at which peak velocity occurs is expressed as a percentage of the normalized movement cycle (0-100%).
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Craniovertebral Angle (CVA)
Craniovertebral angle is measured in degrees in the sagittal plane between a horizontal line passing through the C7 vertebral marker and a line connecting the C7 marker to the tragus marker.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Body Fat Percentage
Body fat percentage is assessed using bioelectrical impedance analysis (BIA). The proportion of total body mass consisting of fat is recorded as a percentage (%).
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Skeletal Muscle Mass
Skeletal muscle mass is assessed using bioelectrical impedance analysis (BIA). The estimated mass of skeletal muscles is recorded in kilograms (kg).
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Fat-Free Mass
Fat-free mass is assessed using bioelectrical impedance analysis (BIA). The estimated mass of body components excluding fat is recorded in kilograms (kg).
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Physical Activity Level (International Physical Activity Questionnaire)
Physical activity is assessed using the International Physical Activity Questionnaire (IPAQ). Total physical activity is calculated in metabolic equivalent minutes per week (MET-min/week) according to the IPAQ scoring protocol. The results are used to confirm participant classification into active and sedentary groups.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Musculoskeletal Discomfort (Nordic Musculoskeletal Questionnaire)
Musculoskeletal discomfort is assessed using the Nordic Musculoskeletal Questionnaire (NMQ). Participants report musculoskeletal problems across nine body regions during the preceding seven days. Point prevalence is calculated as the number of participants reporting problems divided by the total number of participants, expressed as a percentage.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Ergonomic Risk Assessment (Rapid Upper Limb Assessment)
Ergonomic risk is evaluated using the Rapid Upper Limb Assessment (RULA). Postures of the upper arms, lower arms, wrists, neck, trunk, and legs are assessed together with muscle-use and force scores to calculate a grand score ranging from 1 to 7.
Time frame: Baseline (Week 0) and post-intervention (Week 13)
Musculoskeletal Discomfort Severity (Cornell Musculoskeletal Discomfort Questionnaire)
Musculoskeletal discomfort severity is assessed using the Cornell Musculoskeletal Discomfort Questionnaire (CMDQ). Scores are calculated for each body region by multiplying discomfort frequency, severity, and work interference. Scores range from 0 to 90 per body region.
Time frame: Baseline (Week 0) and post-intervention (Week 13).
Global Rating of Change
Participants' perceived overall progress is assessed using the Global Rating of Change (GRoC) scale, ranging from -7 (a very great deal worse) to +7 (a very great deal better), with 0 indicating no change.
Time frame: Post-intervention (Week 13)
System Usability (System Usability Scale)
Usability of the wearable-monitored exercise system is evaluated using the 10-item System Usability Scale (SUS). The total score ranges from 0 to 100, with higher scores indicating better perceived system usability. This assessment is administered to participants in the experimental group.
Time frame: Post-intervention (Week 13)
Intrinsic Motivation Inventory
Intrinsic motivation is assessed using the Intrinsic Motivation Inventory (IMI), evaluating four dimensions: interest/enjoyment, perceived choice, perceived competence, and pressure/tension. Responses are recorded using a 7-point Likert scale. Negatively worded items are reverse-scored, and the subscale score is calculated as the mean of its items. Scores range from 1 to 7, with higher scores indicating greater perceived autonomy and choice (a more favorable outcome).
Time frame: Post-intervention (Week 13)
No study locations are listed for this record.
Start is estimated for Nov 2026; primary completion for Oct 2027, 11 months later.
Of 5,147 non-industry interventional studies with no phase under Motor Activity, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's planned 11 months is below that.
Counting every sponsor, half of 5,207 studies reached it within 17 months; a quarter within 7 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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