An observational study in Acute Respiratory Distress Syndrome and Acute Lung Injury (ALI), sponsored by Oslo University Hospital. Completed at 1 site in Norway. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2010-11-11.
Sponsored by Oslo University Hospital · Observational
The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.
Mechanically ventilated patients often need bronchoscopy as a diagnostic procedure or for visually directed elimination of secretions. Partial endotracheal tube occlusion by the bronchoscope increases airflow resistance. Inhibition of inspiratory flow may be compensated for by augmented inspiratory pressure. Reduced expiratory flow however, cannot be compensated for by most ventilators and could lead to higher airway - and intrathoracic pressures that are not detected by pressure transducers in the ventilator tubing. In this study we compare changes in ventilation, airway pressures, ventilator pressures and blood gases during bronchoscopy of intubated patients in both volume controlled and pressure controlled ventilation. Our hypothesis are that 1) increased resistance in the tube during bronchoscopy leads to high intrabronchial airway pressures when the ventilator is in volume controlled mode, and 2) when the ventilator is in pressure controlled mode, increased resistance in the tube during bronchoscopy leads to reduced Tidal Volume and moderately increased paCO2.
1,596 studies on the registry are indexed under Respiratory Distress Syndrome; 312 are open to participants now.
This study's planned enrollment of 20 is below the median of 100 across 540 observational studies indexed under Respiratory Distress Syndrome.
Browse Respiratory Distress Syndrome studies →Oslo University Hospital is the lead sponsor of 810 studies on the registry; 148 are open to participants now.
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ARDS/ALI patients on mechanical ventilation where a therapeutic or diagnostic bronchoscopy has been requested by the staff physician.
Exclusion Criteria:
Other: Bronchoscopy
Airway pressures, ventilation changes and blood gas changes are recorded in a group of intubated patients on mechanical ventilation before and after bronchoscope insertion. The registration is done immediately before a therapeutic/diagnostic bronchoscopy requested by a staff physician not involved n the study.
Changes in ventilation, airway pressures and blood gases after bronchoscope insertion.
paO2, paCO2 (kPa), airway and ventilator pressures (cmH2O)
Time frame: 2 minutes after bronchoscope insertion/ mode change
This study is completed, as verified in Nov 2010. You cannot join it, but the record below documents what was studied.
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Respiratory Distress Syndrome→
Oslo University Hospital