Regeneron Pharmaceuticals: all 411 studies

Page 2 of 5. Open to participants first (93), then studies with results posted, then the rest; newest registration first within each.

• Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal HemoglobinuriaTerminatedNCT05131204Phase 3Results posted
• A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)TerminatedNCT05088460Phase 2Results posted
• COVID-19 Study to Evaluate Safety, Tolerability, and Efficacy of REGN14256+Imdevimab for the Treatment of COVID-19 Adult and Adolescent Patients Without Risk Factors for Progression to Severe DiseaseTerminatedNCT05081388Phase 1/2Results posted
• A Study to Evaluate Efficacy and Safety of Casirivimab+Imdevimab (Monoclonal Antibodies) for Prevention of COVID-19 in Immunocompromised Adolescents and AdultsTerminatedNCT05074433Phase 3Results posted
• COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of AgeTerminatedNCT04992273Phase 2Results posted
• A Study to Examine the Efficacy and Safety of Anti-Fel d 1 Antibodies Injections in Cat-allergic Adolescent and Adult Patients With Allergic Rhinitis Who Live With a CatTerminatedNCT04981717Phase 3Results posted
• A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic CancerTerminatedNCT04916002Phase 2Results posted
• Pozelimab and Cemdisiran Combination Therapy in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Switch From Eculizumab TherapyCompletedNCT04888507Phase 2Results posted
• Efficacy and Safety of Evinacumab in Adult Patients With Severe Hypertriglyceridemia for the Prevention of Recurrent Acute PancreatitisTerminatedNCT04863014Phase 2Results posted
• COVID-19 Study to Assess Immunogenicity, Safety, and Tolerability of Moderna mRNA-1273 Vaccine Administered With Casirivimab+Imdevimab in Healthy Adult VolunteersCompletedNCT04852978Phase 2Results posted
• Pozelimab and Cemdisiran Combination Treatment in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Received Pozelimab MonotherapyCompletedNCT04811716Phase 2Results posted
• Study to Assess the Efficacy of Anti-Bet v 1 Monoclonal Antibodies in Adults to Reduce Symptoms of Seasonal Allergic RhinitisCompletedNCT04709575Phase 3Results posted
• CMP-001 in Combination With Nivolumab in Subjects With Advanced MelanomaTerminatedNCT04698187Phase 2Results posted
• CMP-001 in Combination With Nivolumab Compared to Nivolumab Monotherapy in Subjects With Advanced MelanomaTerminatedNCT04695977Phase 2/3Results posted
• COVID-19 Study Assessing the Virologic Efficacy of REGN10933+REGN10987 Across Different Dose Regimens in Adult Outpatients With SARS-CoV-2 InfectionCompletedNCT04666441Phase 2Results posted
• Cemiplimab and ISA101b Vaccine in Adult Participants With Recurrent/Metastatic Human Papillomavirus (HPV)16 Cervical Cancer Who Have Experienced Disease Progression After First Line ChemotherapyCompletedNCT04646005Phase 2Results posted
• CMP-001 in Combination With Pembrolizumab in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaTerminatedNCT04633278Phase 2Results posted
• COVID-19 Study Assessing the Efficacy and Safety of Anti-Spike SARS CoV-2 Monoclonal Antibodies for Prevention of SARS CoV-2 Infection Asymptomatic in Healthy Adults and Adolescents Who Are Household Contacts to an Individual With a Positive SARS-CoV-2 RT-PCR AssayCompletedNCT04452318Phase 3Results posted
• Investigating Treatment With Dupilumab in Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED)CompletedNCT04442269Phase 2Results posted
• Study of a High-Dose Aflibercept in Participants With Diabetic Eye DiseaseCompletedNCT04429503Phase 2/3Results posted
• Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19CompletedNCT04426695Phase 1/2Results posted
• Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult and Pediatric Patients With COVID-19TerminatedNCT04425629Phase 3Results posted
• A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Moderate-to-Severe Atopic Hand and Foot Dermatitis (Liberty-AD-HAFT)CompletedNCT04417894Phase 3Results posted
• Study to Investigate the Efficacy and Safety of Dupilumab in Pediatric Patients With Active Eosinophilic Esophagitis (EoE)CompletedNCT04394351Phase 3Results posted
• Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19CompletedNCT04315298Phase 2/3Results posted
• Evaluate the Efficacy and Safety of Evinacumab in Pediatric Patients With Homozygous Familial HypercholesterolemiaCompletedNCT04233918Phase 3Results posted
• Open-Label Efficacy and Safety Study of Pozelimab in Patients With CD55-Deficient Protein-Losing Enteropathy (CHAPLE Disease)CompletedNCT04209634Phase 2/3Results posted
• A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients With Bullous PemphigoidCompletedNCT04206553Phase 2/3Results posted
• A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With AsthmaCompletedNCT04203797Phase 4Results posted
• REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate Its Long Term Safety, Efficacy and Tolerability.TerminatedNCT04162470Phase 3Results posted
• Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized LipodystrophyCompletedNCT04159415Phase 2Results posted
• Study of Cemiplimab in Patients With Type of Skin Cancer Stage II to IV Cutaneous Squamous Cell CarcinomaCompletedNCT04154943Phase 2Results posted
• Safety, Tolerability, and Efficacy of Aflibercept in Patients With Neovascular Age-Related Macular DegenerationCompletedNCT04126317Phase 2Results posted
• Study to Assess the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Compared to Laser Photocoagulation in Patients With Retinopathy of PrematurityCompletedNCT04101721Phase 3Results posted
• A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the KneeTerminatedNCT03956550Phase 2Results posted
• Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and HipTerminatedNCT03949673Phase 2Results posted
• Study to Evaluate the Efficacy and Safety of REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)CompletedNCT03946748Phase 2Results posted
• Study in Cat-Allergic Patients With Asthma to Evaluate the Efficacy of a Single Dose of REGN1908-1909 to Reduce Bronchoconstriction Upon Cat Allergen ChallengeCompletedNCT03838731Phase 2Results posted
• Study to Evaluate Dupilumab Monotherapy in Pediatric Patients With Peanut AllergyCompletedNCT03793608Phase 2Results posted
• Study to Evaluate an Aflibercept (EYLEA®) Prefilled SyringeCompletedNCT03767738Phase 4Results posted
• Efficacy, Safety, and Pharmacokinetic Profiles of REGN3500 Administered to Adult Patients With Moderate-to-Severe Atopic DermatitisTerminatedNCT03738423Phase 2Results posted
• Efficacy and Safety of REGN3500 Monotherapy and Combination of REGN3500 Plus Dupilumab in Adult Patients With Moderate-to-Severe Atopic DermatitisTerminatedNCT03736967Phase 2Results posted
• Long Term Safety Study of PRALUENTTerminatedNCT03694197Phase 4Results posted
• Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or KneeCompletedNCT03691974Phase 2Results posted
• REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent GliomaTerminatedNCT03690869Phase 1/2Results posted
• Study in Pediatric Subjects With Peanut Allergy to Evaluate Efficacy and Safety of Dupilumab as Adjunct to AR101 (Peanut Oral Immunotherapy)CompletedNCT03682770Phase 2Results posted
• Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)CompletedNCT03633617Phase 3Results posted
• Dupilumab As An Adjunct For Subcutaneous Grass ImmunotherapyCompletedNCT03558997Phase 2Results posted
• REGN2810 (Anti-PD-1 Antibody), Platinum-based Doublet Chemotherapy, and Ipilimumab (Anti-CTLA-4 Antibody) Versus Pembrolizumab Monotherapy in Patients With Lung CancerTerminatedNCT03515629Phase 3Results posted
• Safety and Efficacy Following Repeat-Dose of Evinacumab (Anti-ANGPTL3) in Patients With Severe Hypertriglyceridemia (sHTG) at Risk for Acute PancreatitisCompletedNCT03452228Phase 2Results posted
• A Study of REGN2810 and Ipilimumab in Patients With Lung CancerTerminatedNCT03430063Phase 2Results posted
• Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT03409744Phase 3Results posted
• Combinations of Cemiplimab (Anti-PD-1 Antibody) and Platinum-based Doublet Chemotherapy in Patients With Lung CancerCompletedNCT03409614Phase 3Results posted
• Efficacy and Safety of Evinacumab in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT03399786Phase 3Results posted
• Safety, Pharmacokinetics and Efficacy of Dupilumab in Patients ≥6 Months to <6 Years With Moderate-to-Severe Atopic Dermatitis (Liberty AD PRESCHOOL)CompletedNCT03346434Phase 2/3Results posted
• Study to Investigate the Efficacy and Safety of Dupilumab Administered With Topical Corticosteroids (TCS) in Participants ≥6 to <12 Years With Severe Atopic Dermatitis (AD)CompletedNCT03345914Phase 3Results posted
• Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or HipCompletedNCT03304379Phase 3Results posted
• Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or KneeTerminatedNCT03285646Phase 3Results posted
• Study of Cemiplimab in Adults With Cervical CancerCompletedNCT03257267Phase 3Results posted
• A Study to Examine the Safety, Tolerability and Effects on Abnormal Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans ProgressivaCompletedNCT03188666Phase 2Results posted
• Study of Evinacumab (REGN1500) in Participants With Persistent HypercholesterolemiaCompletedNCT03175367Phase 2Results posted
• A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or HipCompletedNCT03161093Phase 3Results posted
• Study in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT03156621Phase 3Results posted
• PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor TherapyCompletedNCT03132636Phase 2Results posted
• Study of REGN 2810 Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC)CompletedNCT03088540Phase 3Results posted
• Efficacy and Safety of Dupilumab in Participants ≥12 to <18 Years of Age, With Moderate-to-severe Atopic DermatitisCompletedNCT03054428Phase 3Results posted
• Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to PlaceboCompletedNCT02957682Phase 4Results posted
• Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell CarcinomaCompletedNCT02760498Phase 2Results posted
• A Study to Assess the Efficacy and Safety of Dupilumab in Participants With Severe Atopic Dermatitis (AD) That Are Not Controlled With Oral Cyclosporine A (CSA) or for Those Who Cannot Take Oral CSA Because it is Not Medically AdvisableCompletedNCT02755649Phase 3Results posted
• Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR)CompletedNCT02718326Phase 3Results posted
• Anti-angiOpoeitin 2 Plus Anti-vascular eNdothelial Growth Factor as a therapY for Neovascular Age Related Macular Degeneration: Evaluation of a fiXed Combination Intravitreal InjectionCompletedNCT02713204Phase 2Results posted
• Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of Diabetic Macular EdemaCompletedNCT02712008Phase 2Results posted
• Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or HipCompletedNCT02683239Phase 3Results posted
• A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back PainCompletedNCT02620020Phase 2/3Results posted
• Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-Related Macular Degeneration (AMD)TerminatedNCT02418754Phase 2Results posted
• A Study to Determine the Safety and Tolerability of Dupilumab (REGN668/SAR231893) in Patients Aged ≥6 to <18 Years With Atopic Dermatitis (Eczema)CompletedNCT02407756Phase 2Results posted
• A Study to Confirm the Efficacy and Safety of Different Dupilumab Dose Regimens in Adults With Atopic Dermatitis (AD)CompletedNCT02395133Phase 3Results posted
• Study of Dupilumab in Adult Participants With Active Eosinophilic Esophagitis (EoE)CompletedNCT02379052Phase 2Results posted
• Study of Alirocumab (REGN727/SAR236553) in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) Undergoing Low-density Lipoprotein (LDL) Apheresis TherapyCompletedNCT02326220Phase 3Results posted
• Study to Evaluate the Efficacy and Safety of Suptavumab (REGN2222) for the Prevention of Medically Attended RSV (Respiratory Syncytial Virus) Infection in Preterm InfantsCompletedNCT02325791Phase 3Results posted
• Study of Dupilumab (REGN668/SAR231893) Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic DermatitisCompletedNCT02277769Phase 3Results posted
• Study of Dupilumab Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic DermatitisCompletedNCT02277743Phase 3Results posted
• Study of REGN1500 in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT02265952Phase 2Results posted
• Study to Assess the Efficacy and Long-term Safety of Dupilumab (REGN668/SAR231893) in Adult Participants With Moderate-to-Severe Atopic DermatitisCompletedNCT02260986Phase 3Results posted
• Study of Dupilumab and Immune Responses in Adults With Atopic Dermatitis (AD)CompletedNCT02210780Phase 2Results posted
• Study to Determine the Safety and Effectiveness of Dupilumab for Treatment of Atopic Dermatitis (AD)CompletedNCT01979016Phase 2Results posted
• Open-label Study of Dupilumab in Patients With Atopic DermatitisCompletedNCT01949311Phase 3Results posted
• Study to Evaluate the Efficacy and Safety of an Every Four Weeks Treatment Regimen of Alirocumab (REGN727/ SAR236553) in Patients With Primary Hypercholesterolemia (ODYSSEY CHOICE 1)CompletedNCT01926782Phase 3Results posted
• Study of Dupilumab Administered to Adult Patients With Moderate-to-Severe Atopic DermatitisCompletedNCT01859988Phase 2Results posted
• Study of Alirocumab (REGN727/SAR236553) added-on to Rosuvastatin Versus Other Lipid Modifying Treatments (LMT) (ODYSSEY OPTIONS II)CompletedNCT01730053Phase 3Results posted
• Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I)CompletedNCT01730040Phase 3Results posted
• Study to Assess Best Corrected Visual Acuity (BCVA) in Patients With Neovascular Age-Related Macular Degeneration (AMD) Who Are Administered VEGF Trap-Eye (Intravitreal Aflibercept Injection)CompletedNCT01722045Phase 4Results posted
• Study of Alirocumab (REGN727/SAR236553) in Patients With Primary Hypercholesterolemia and Moderate, High, or Very High Cardiovascular (CV) Risk, Who Are Intolerant to Statins (ODYSSEY ALTERNATIVE)CompletedNCT01709513Phase 3Results posted
• Study of Alirocumab (REGN727/SAR236553) in Patients With heFH (Heterozygous Familial Hypercholesterolemia) Who Are Not Adequately Controlled With Their LMT (Lipid-Modifying Therapy)CompletedNCT01709500Phase 3Results posted
• Study to Assess the Safety of Dupilumab (REGN668/SAR231893) Administered Concomitantly With Topical Corticosteroids (TCS) in Patients With Moderate-to-severe Atopic Dermatitis (AD)CompletedNCT01639040Phase 2Results posted
• A Study of Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B GeneCompletedNCT01604824Phase 2Results posted
• Open-Label Extension of Study R727-CL-1003 (NCT01266876) to Evaluate the Long-Term Safety and Efficacy of Alirocumab (REGN727) in Participants With Heterozygous Familial Hypercholesterolemia (HeFH)CompletedNCT01576484Phase 2Results posted
• Study of Dupilumab in Adult Patients With Extrinsic Moderate-to-Severe Atopic DermatitisCompletedNCT01548404Phase 2Results posted
• Study to Assess the Clinical Efficacy and Safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) in Patients With Branch Retinal Vein Occlusion (BRVO)CompletedNCT01521559Phase 3Results posted
• Study of the Safety and Efficacy of Long-Term Rilonacept Treatment for the Prevention of Gout FlaresTerminatedNCT01459796Phase 3Results posted

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