Regeneron Pharmaceuticals: all 411 studies

Page 3 of 5. Open to participants first (93), then studies with results posted, then the rest; newest registration first within each.

• Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of AllopurinolCompletedNCT01451645Phase 4Results posted
• Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular EdemaCompletedNCT01363440Phase 3Results posted
• Study of the Safety and Efficacy of REGN727/SAR236553 in Patients With HeFH HypercholesterolemiaCompletedNCT01266876Phase 2Results posted
• Open-label Extension Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Neovascular ("Wet") Age-related Macular Degeneration (AMD)CompletedNCT00964795Phase 3Results posted
• PREventative Study Against URate-Lowering Drug-Induced Gout Exacerbations (PRE-SURGE 2)CompletedNCT00958438Phase 3Results posted
• Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)CompletedNCT00943072Phase 3Results posted
• Review of Safety Using Rilonacept in Preventing Gout Exacerbations (RE-SURGE)CompletedNCT00856206Phase 3Results posted
• Study Utilizing Rilonacept in Gout ExacerbationsCompletedNCT00855920Phase 3Results posted
• PREventative Study Against URate-lowering Drug-induced Gout Exacerbations 1CompletedNCT00829829Phase 3Results posted
• A Study of Aflibercept Administered in Combination With Pemetrexed and Cisplatin in Participants With Advanced CarcinomaTerminatedNCT00794417Phase 1/2Results posted
• DME And VEGF Trap-Eye [Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321)] INvestigation of Clinical ImpactCompletedNCT00789477Phase 2Results posted
• Study of the Safety and Effectiveness of Rilonacept for the Prevention of Gout FlaresCompletedNCT00610363Phase 2Results posted
• Randomized, Single-Masked, Long-Term, Safety and Tolerability Study of VEGF Trap-Eye in AMDCompletedNCT00527423Phase 2Results posted
• Vascular Endothelial Growth Factor VEGF Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)CompletedNCT00509795Phase 3Results posted
• Safety and Efficacy of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor (VEGF) Trap in Patients With Wet Age-Related Macular Degeneration (AMD)CompletedNCT00320788Phase 2Results posted
• Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS)CompletedNCT00288704Phase 3Results posted
• A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have HypercholesterolemiaActive, not recruitingNCT07477704Phase 2
• Study of Olatorepatide in Adult Participants Living With Overweight or Obesity in the USActive, not recruitingNCT07431086Phase 2
• A Study of Linvo-VR vs DVRd in Transplant-Eligible Adult Participants With Newly Diagnosed Multiple Myeloma (NDMM)WithdrawnNCT07428369Phase 2/3
• Study of Bet v1 Antibodies Effect on Eye Allergy Symptoms in Adolescents and Adults With Birch Pollen AllergyTerminatedNCT07309432Phase 3
• An Expanded Access Program of Garetosmab in Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP)Approved for marketingNCT07301450
• A Study of REGN7041 for Active Noninfectious Uveitis in Adult ParticipantsTerminatedNCT07218770Phase 1/2
• Study of Growth and Bone Mineral Density in Children With Atopic Dermatitis (AD) Treated With DupilumabWithdrawnNCT07187089Phase 4
• Incidence of Retinal Vasculitis Among Patients Receiving Aflibercept: A US Real-World Evidence StudyCompletedNCT07105228
• Study of Safety and Effects of Garetosmab in Healthy Obese Men and Post-Menopausal WomenWithdrawnNCT06970405Phase 1
• REGN5381 in Adult Participants With Uncontrolled HypertensionTerminatedNCT06833190Phase 2
• ALN-APOC3 in Adult Participants With DyslipidemiaCompletedNCT06784349Phase 1
• A Real-World Evidence Study for the Incidence of Retinal Vasculitis (RV) Among Adult Patients Receiving Aflibercept 2 mg in the United States (US)CompletedNCT06769412
• A U.S. Registry of Eosinophilic Esophagitis Pediatric, Adolescent and Adult Patients Treated With DUPIXENT® As Standard of CareActive, not recruitingNCT06693531
• Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy AdultsCompletedNCT06669234Phase 1
• Phase 1 Safety and Tolerability Study of REGN9533 in Healthy AdultsCompletedNCT06665828Phase 1
• A Study of REGN7544 for the Treatment in Adult Patients With Sepsis-Induced HypotensionCompletedNCT06608901Phase 2
• A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen AllergyCompletedNCT06602739Phase 3
• A Study to Demonstrate How Well REGN1908-1909 Works in Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Cat AllergyCompletedNCT06602726Phase 3
• Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)CompletedNCT06593600Phase 2
• Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled AsthmaActive, not recruitingNCT06572228Phase 4
• A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)CompletedNCT06548100Phase 3
• Compassionate Use of EvinacumabApproved for marketingNCT06500598
• A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)Active, not recruitingNCT06465329Phase 2
• A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy AdultsActive, not recruitingNCT06452771Phase 1
• Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult ParticipantsCompletedNCT06444178Phase 1
• A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the BodyActive, not recruitingNCT06421636Phase 2
• An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World SettingWithdrawnNCT06398080
• Study of Cemiplimab Alone or in Combination With Fianlimab and/or Other Experimental Agents in Adult Participants With Peri-operative Stage III/IV Cutaneous Squamous Cell Carcinoma (CSCC)WithdrawnNCT06384820Phase 2
• Short-Term Linvoseltamab Treatment on Top of Chronic Dupilumab Treatment for Adults With Severe Immunoglobulin E (IgE)-Mediated Food AllergyActive, not recruitingNCT06369467Phase 1
• A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)CompletedNCT06299111Phase 2
• A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass PreservationActive, not recruitingNCT06299098Phase 2
• Evaluation of Cemiplimab in Combination With Platinum-Doublet Chemotherapy in First-Line (1L) Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) in Adult United States (US) ParticipantsActive, not recruitingNCT06269133
• REGN5381 in Adult Participants With Heart Failure With Reduced Ejection FractionTerminatedNCT06237309Phase 2
• A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin LymphomaActive, not recruitingNCT06230224Phase 3
• A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 MelanomaActive, not recruitingNCT06190951Phase 2
• A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With SurgeryActive, not recruitingNCT06161441Phase 2
• A Study to See How Safe and Tolerable Different Doses of REGN13335 Are When Administered Intravenously (IV) or Subcutaneously (SC) to Healthy Adult ParticipantsCompletedNCT06137482Phase 1
• Expanded Access Use of Cemiplimab in Patients With Solid TumorsApproved for marketingNCT06132191
• A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular LymphomaActive, not recruitingNCT06097364Phase 3
• A Non-Interventional Study of Clinical Characteristics and Mortality of US Patients With Fibrodysplasia Ossificans Progressiva (FOP)CompletedNCT06064656
• Compassionate Use of VidutolimodNo longer availableNCT06063746
• Compassionate Use of Pozelimab and Cemdisiran Combination Therapy in Patients With Paroxysmal Nocturnal HemoglobinuriaNo longer availableNCT06028594
• A Trial to Learn if Receiving ALN-PNP siRNA is Safe and Well Tolerated, and How it Works in Adult Participants With Nonalcoholic Fatty Liver Disease (NAFLD) and a Genetic Risk FactorCompletedNCT06024408Phase 1
• A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 MutationsWithdrawnNCT06019481
• Compassionate Use of Pozelimab in Patients With CD55-Deficient Protein-Losing EnteropathyApproved for marketingNCT06003881
• A Trial to Learn if Different Doses of REGN7544 Are Safe in Healthy Adult ParticipantsCompletedNCT05970718Phase 1
• A Proof-of-Concept Trial to Study the Safety and Activity of Linvoseltamab in Adult Participants With Smoldering Multiple Myeloma at High Risk of Developing Multiple MyelomaActive, not recruitingNCT05955508Phase 2
• A Trial to Learn if Different Doses of REGN17092 Are Safe in Healthy AdultsCompletedNCT05923424Phase 1
• Compassionate Use of Dupilumab for Adult Patients With Bullous PemphigoidApproved for marketingNCT05906706
• A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May HaveActive, not recruitingNCT05831176Phase 2
• A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung CancerActive, not recruitingNCT05800015Phase 2/3
• A Study of the Incidence of Intraocular Inflammation and Suspected Endophthalmitis Among Patients Treated With Aflibercept, Vial and Pre-filled Syringe, 2014-2022CompletedNCT05791695
• A Study to Learn if a Combination of Fianlimab and Cemiplimab Versus Cemiplimab Alone is More Effective for Adult Participants With Advanced Non-Small Cell Lung Cancer (NSCLC)Active, not recruitingNCT05785767Phase 2/3
• Real-World Clinical Outcomes in Patients With Relapsed/Refractory Multiple MyelomaCompletedNCT05673967
• A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With SurgeryActive, not recruitingNCT05608291Phase 3
• A Trial to Learn if Single Ascending Intravenous (IV) Doses of REGN7508 Are Safe and Well Tolerated, and How it Works in the Body of Healthy Adult ParticipantsCompletedNCT05603195Phase 1
• A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement TherapyActive, not recruitingNCT05568459
• A Trial to Learn How the Cancer Vaccine BNT116 in Combination With Cemiplimab Works and How Safe the Combination is in Adults With Advanced Non-small Cell Lung Cancer (EMPOWERVAX Lung 1)Active, not recruitingNCT05557591Phase 2
• Assess Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban in Healthy Adult ParticipantsCompletedNCT05546957Not applicable
• A Trial to Learn if a COVID-19 Therapeutic is Safe and Well Tolerated, and How it Works in the Body of Healthy Adult ParticipantsCompletedNCT05505448Phase 1
• A Trial to Learn if REGN7999 is Safe and Well Tolerated, and How it Works in the Body of Healthy ParticipantsCompletedNCT05481333Phase 1
• Genetic Data Collection in Adult Participants to Identify Genetic Variants of Known Importance in Non-alcoholic Steatohepatitis (NASH)TerminatedNCT05423327Not applicable
• A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP)Active, not recruitingNCT05394116Phase 3
• Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic MelanomaActive, not recruitingNCT05352672Phase 3
• Real-World Clinical Outcomes in Adult Patients Who Initiate Systemic Treatment for Relapsed/Refractory Diffuse Large B-Cell LymphomaCompletedNCT05338892
• Real-World Clinical Outcomes in Adult Patients Who Initiate Systemic Treatment for Relapsed or Refractory Follicular LymphomaCompletedNCT05338879
• Safety and Tolerability of Regeneron Anti-SARS-CoV-2 Monoclonal Antibody/Ies in Adult Healthy Volunteers as Related to COVID-19CompletedNCT05293678Phase 1
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9035 in Healthy Adult Volunteers and Mildly Hypertensive ParticipantsCompletedNCT05291546Phase 1
• A Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants With Solid Cancers Treated With CemiplimabActive, not recruitingNCT05259709Phase 1
• Compassionate Use of PozelimabApproved for marketingNCT05232110
• Neuropsychologic Assessments of Dupilumab-Treated Adolescent Participants With Moderate-to-Severe Atopic DermatitisCompletedNCT05203380
• COVID-19 Study Assessing the Safety and Tolerability of Co-Formulated Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) in Adult VolunteersCompletedNCT05181683Phase 1
• A Study of bbT369 in Relapsed and/or Refractory B Cell Non-Hodgkin's Lymphoma (NHL)TerminatedNCT05169489Phase 1
• Compassionate Use (CU) of REGN5458 for Patients With Relapsed or Refractory Multiple Myeloma (MM)Approved for marketingNCT05164250
• A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor TreatmentActive, not recruitingNCT05133531Phase 3
• Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9933 in Adult Healthy VolunteersCompletedNCT05102136Phase 1
• COVID-19 Study of Pharmacokinetics, Safety, Tolerability, and Efficacy of Intravenous Anti-Spike(s) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) for the Treatment of Pediatric Patients Hospitalized Due to COVID-19TerminatedNCT05092581Phase 1
• A Study to Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)Active, not recruitingNCT05092347Phase 1/2
• A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia GravisActive, not recruitingNCT05070858Phase 3
• Study of REGN5093-M114 (METxMET Antibody-Drug Conjugate) in Adult Patients With Mesenchymal Epithelial Transition Factor (MET) Overexpressing Advanced CancerTerminatedNCT04982224Phase 1
• Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)Active, not recruitingNCT04959448
• A Study to Examine the Safety, Tolerability and Biological Effects of Single Doses of Subcutaneously and Intravenously Administered Pozelimab as Monotherapy and in Combination With Single Doses of Subcutaneously Administered Cemdisiran in Adult Japanese Healthy VolunteersCompletedNCT04940364Phase 1
• A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced CancersActive, not recruitingNCT04626635Phase 1/2
• Compassionate Use of REGN-COV2 for the Treatment of COVID-19No longer availableNCT04617535

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