Regeneron Pharmaceuticals: all 411 studies

Page 1 of 5. Open to participants first (93), then studies with results posted, then the rest; newest registration first within each.

• Efficacy And Safety of Olatorepatide in Adults With Overweight or Obesity Without DiabetesNot yet recruitingNCT07896265Phase 3
• REGN9220 in Combination With Odronextamab in Adult Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphomas (BCNHLs)Not yet recruitingNCT07887750Phase 1/2
• Healthy Adult Participants Trial Comparing Different Cenvacibart PresentationsNot yet recruitingNCT07876505Phase 1
• A Study to Evaluate Cenvacibart (REGN7508) for Secondary Stroke Prevention in Adult ParticipantsNot yet recruitingNCT07876492Phase 3
• Safety and Efficacy Study in Adults With Advanced Solid Tumors Receiving REGN13089-M404-M2980, an Antibody-drug Conjugate That Targets MET Protein on TumorsNot yet recruitingNCT07863024Phase 1/2
• Thyroid-Stimulating Hormone Receptor (TSHR) Blockade With REGN24493 in Adult Participants With Graves' Disease (GD)Not yet recruitingNCT07861152Phase 1
• Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)Not yet recruitingNCT07854782Phase 3
• REGN21353 Alone or in Combination With Nezastomig for Metastatic Castration-Resistant Prostate Cancer in Adult ParticipantsNot yet recruitingNCT07850921Phase 1/2
• A Trial of ALN-6457 in Adult Participants With Symptomatic Prion Disease (PrD)Not yet recruitingNCT07832370Phase 1/2
• Efficacy and Safety of Olatorepatide Versus Placebo in Adults With Moderate to Severe Hidradenitis Suppurativa Living With Overweight or ObesityNot yet recruitingNCT07830329Phase 2
• A Study Comparing Cemiplimab-based Treatments for Adult Participants With Locally Advanced Basal Cell Skin Cancer (laBCC)Not yet recruitingNCT07808515Phase 2
• Compassionate Use of VonsetamigAvailableNCT07780110
• Study of 3 Monoclonal Antibodies (REGN9933, REGN7508, and REGN9533) in Adult Participants With End-Stage Kidney Disease on HemodialysisRecruitingNCT07759167Phase 1
• Safety and Tolerability of REGN17235 in Adult Participants With Clonal Cytopenia of Undetermined Significance and Low-Risk Myelodysplastic Syndrome With SF3B1 MutationNot yet recruitingNCT07753148Phase 1
• A Study to Identify and Characterize Adults and Pediatric Participants With Cat and/or Birch AllergyNot yet recruitingNCT07710846
• Venous Thromboembolism (VTE) Prophylaxis With REGN7508 and REGN9933 in Adult and Adolescent Participants With a Peripherally Inserted Central Catheter (PICC)RecruitingNCT07697599Phase 3
• Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without DiabetesRecruitingNCT07685808Phase 2
• REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular HypertensionRecruitingNCT07675824Phase 1/2
• A Study to Evaluate the Efficacy and Safety of Fel d 1 Monoclonal Antibodies in Adult and Pediatric Participants With Allergic Conjunctivitis Due to Cat AllergyRecruitingNCT07675811Phase 3
• Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)RecruitingNCT07631637Phase 2
• Stroke and Systemic Embolism Prevention in Adult Participants With Atrial FibrillationRecruitingNCT07626411Phase 3
• Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS)RecruitingNCT07609940Phase 4
• REGN15505 (PSMAx4-1BB) Alone or in Combination With Cemiplimab or REGN4336 (PSMAxCD3) in Adult Patients With Metastatic Castration-Resistant Prostate Cancer and Clear Cell Renal Cell CarcinomaRecruitingNCT07594106Phase 1/2
• Safety and Drug Concentrations of REGN20934 in Adults With Overweight or ObesityRecruitingNCT07594093Phase 1
• This After Market Study is Seeing if Dupilumab Plus Usual Standard of Care (SOC) is Better Than Usual Care Alone for Adult Participants After a Severe Chronic Obstructive Pulmonary Disease (COPD) Flare-Up Requiring HospitalizationRecruitingNCT07587658Phase 4
• A Safety and Efficacy Study of Combined Fianlimab + Cemiplimab in Children and Young Adults With Recurrent or Progressive High-Grade Glioma or Posterior Fossa-A EpendymomaNot yet recruitingNCT07567469Phase 1/2
• A Study to Investigate the Safety, Pharmacokinetics (PK), and Efficacy of Garetosmab in Children and Adolescents With Fibrodysplasia Ossificans Progressiva (FOP)Not yet recruitingNCT07559513Phase 3
• A Phase 1 Study of BPX-601 CAR T-Cell Therapy in Adult Participants With Prostate Cancer That Has Returned, is Resistant to Treatment and Has SpreadRecruitingNCT07543055Phase 1
• First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic DermatitisRecruitingNCT07527923Phase 1
• A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLDRecruitingNCT07527910Phase 2
• A First in Human Study to Assess Safety, Tolerability and Pharmacokinetics of a Single Dose of REGN22044 in Healthy AdultsRecruitingNCT07526116Phase 1
• Compassionate Use of UbamatamabAvailableNCT07502716
• Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic CancersRecruitingNCT07493304Phase 3
• A Trial to Study if REGN17372 in Combination With Linvoseltamab is Tolerable for Adult Participants With Relapsed/Refractory Multiple MyelomaRecruitingNCT07455851Phase 1/2
• Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is UnsuitableRecruitingNCT07430956Phase 3
• REGN7508 in Adult Participants for Prevention of Cancer-Associated ThrombosisRecruitingNCT07410117Phase 3
• A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)RecruitingNCT07393282Phase 3
• Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery DiseaseRecruitingNCT07318610Phase 3
• Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)RecruitingNCT07318597Phase 2
• Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney DiseaseRecruitingNCT07271186Phase 2
• A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic AmenorrheaRecruitingNCT07235917Phase 2
• Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult ParticipantsRecruitingNCT07230834Phase 1
• A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)RecruitingNCT07222761Phase 3
• Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized LipodystrophyRecruitingNCT07220785Phase 3
• A Study Evaluating Mibavademab Treatment of Obesity Due to Leptin (LEP) Gene Mutations in Children, Adolescents and AdultsRecruitingNCT07220772Phase 3
• First-in-Human Study of ALN-SNCA in Adult Participants With Early Parkinson's Disease (PD)RecruitingNCT07216066Phase 1
• REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult ParticipantsRecruitingNCT07213778Phase 3
• A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 InhibitorRecruitingNCT07187401Phase 1/2
• Safety in Adult Participants With Atrial Fibrillation Who Are Treated With AnticoagulationRecruitingNCT07175428Phase 2
• A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working EfficientlyRecruitingNCT07154745Phase 3
• A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)RecruitingNCT07154290Phase 2
• A Study to Test the Safety of Pozelimab in Pediatric Participants 1 to 5 Years of Age With a Rare Disease Called CHAPLE (Complement Hyperactivation, Angiopathic Thrombosis, Protein-losing Enteropathy) DiseaseRecruitingNCT07142343Phase 4
• A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic EsophagitisRecruitingNCT07112378Phase 3
• REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in AdultsRecruitingNCT07015905Phase 3
• Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus NephritisRecruitingNCT06975787Phase 1
• A Study to Learn About the Long-Term Health of Adult Participants From a Previous Study of a New Melanoma TreatmentEnrolling by invitationNCT06848088Phase 2
• A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH)RecruitingNCT06836609Phase 1/2
• A Safety and Efficacy Long-Term Follow-up Study of Adult Participants Treated With Gene Modified T CellsRecruitingNCT06798298
• Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian CancerRecruitingNCT06787612Phase 2
• A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaRecruitingNCT06769698Phase 2
• A Study to Assess the Safety and Anti-Tumor Activity of REGN7945 in Combination With Linvoseltamab in Adult Participants With Relapsed/Refractory Multiple MyelomaRecruitingNCT06669247Phase 1/2
• Expanded Access of Dupilumab in Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy Previously Treated With LinvoseltamabAvailableNCT06631677
• Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell CarcinomaRecruitingNCT06585410Phase 3
• A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic AtrophyRecruitingNCT06541704Phase 3
• A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian CancersRecruitingNCT06469281Phase 1
• A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their BodyRecruitingNCT06413680Phase 1/2
• A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia BRecruitingNCT06379789Phase 1/2
• First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)RecruitingNCT06351592Phase 1/2
• A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)RecruitingNCT06292780Phase 1/2
• A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)RecruitingNCT06246916Phase 3
• A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone LymphomaRecruitingNCT06149286Phase 3
• A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple MyelomaRecruitingNCT06140524Phase 2
• A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell LymphomaRecruitingNCT06091865Phase 3
• A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular LymphomaRecruitingNCT06091254Phase 3
• A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received TreatmentRecruitingNCT05828511Phase 1/2
• A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin MutationsRecruitingNCT05788536Phase 1/2
• A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it WorksRecruitingNCT05744921Phase 3
• A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple MyelomaRecruitingNCT05730036Phase 3
• A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin LymphomasRecruitingNCT05685173Phase 1
• A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)RecruitingNCT05648214Phase 1/2
• A Compassionate Use (CU) Program of OdronextamabAvailableNCT05619367
• A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This ConditionRecruitingNCT05519475Phase 2
• An Observational Study to Assess the Effectiveness and Safety of a Cemiplimab in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) in Routine Clinical Practice Settings in EuropeRecruitingNCT05363319
• A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care TreatmentsRecruitingNCT05137054Phase 1
• A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate CancerRecruitingNCT05125016Phase 1/2
• An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney TransplantRecruitingNCT05106387
• Compassionate Use or Expanded Access of DupilumabAvailableNCT04776694
• Expanded Access to REGN4461 for Patients With Diseases Associated With Deficient Leptin SignalingAvailableNCT04710056
• A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or UbamatamabRecruitingNCT04590326Phase 1/2
• A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other TumorsRecruitingNCT03972657Phase 1/2
• Phase 1/2 Study of Linvoseltamab in Adult Patients With Relapsed or Refractory Multiple MyelomaRecruitingNCT03761108Phase 1/2
• R3470-3471-3479 (REGN-EB3) Expanded Access Protocol (EAP) for Treatment of Ebola Virus DiseaseAvailableNCT03576690
• Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) CancersRecruitingNCT03564340Phase 1/2
• A Phase 3b, Single-Arm Study of Aflibercept 8 mg Dosed Every 4 Weeks in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)Active, not recruitingNCT06491914Phase 3Results posted
• A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult ParticipantsCompletedNCT06454630Phase 2Results posted
• Study to Evaluate an 8 mg Aflibercept (EYLEA®) Prefilled Syringe (PFS)CompletedNCT05989126Phase 3Results posted
• A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult ParticipantsCompletedNCT05618808Phase 2Results posted
• Dupilumab in Adolescent and Adult Skin of Color Participants: Open-label Moderate-to-severe Eczema TrialCompletedNCT05590585Phase 4Results posted
• Efficacy of the Anti-Bet v 1 Monoclonal Antibodies (Given Subcutaneously) to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen in Adult ParticipantsCompletedNCT05430919Phase 2Results posted
• REGN5381 in Heart Failure Adult Participants With Elevated Pulmonary Capillary Wedge PressureCompletedNCT05353166Phase 2Results posted

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