National Cancer Institute (NCI): Immunologic Deficiency Syndromes trials

The registry lists 19 Immunologic Deficiency Syndromes studies with National Cancer Institute (NCI) as lead sponsor. 4 are open to participants now and 2 have results posted.

Phase 1 2Phase 2 6Phase 3 1No phase 10(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) SyndromeRecruitingNCT05027945Phase 2
• Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman DiseaseRecruitingNCT03300830
• Allogeneic Hematopoietic Stem Cell Transplant for GATA2 MutationsRecruitingNCT01861106Phase 2
• Apheresis of Patients With ImmunodeficiencyRecruitingNCT01212055
• Allogeneic Hematopoietic Stem Cell Transplantation With Briquilimab-Based Conditioning in Participants With GATA2 DeficiencyActive, not recruitingNCT05907746Phase 2Results posted
• Pilot and Feasibility Study of Reduced-Intensity Hematopoietic Stem Cell Transplant for MonoMACCompletedNCT00923364Phase 2Results posted
• Breadth of Donor Options for People With Inherited Diseases Requiring Allogeneic Hematopoietic Stem Cell Transplant in the Era of Alternative Donor Transplants Using Post-Transplantation CyclophosphamideCompletedNCT03188419
• Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 DeficiencyActive, not recruitingNCT01176006Phase 2
• A Pilot Study of Adherence to Oral Medication and Health Beliefs of Adolescents With HIV and Their MothersCompletedNCT00001699
• Clinical, Laboratory and Epidemiologic Pilot Studies of Individuals at High Risk for Viral-Associated CancersCompletedNCT00001560
• Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex TraitsCompletedNCT00001500
• A Phase I /II Study of the Protease Inhibitor Indinavir (MK-0639) in Children With HIV InfectionCompletedNCT00001443Phase 1
• A Pilot Study of the Combination of Retinoic Acid and Interferon-Alpha2a for the Treatment of Lymphoproliferative Disorders in Children With Immunodeficiency SyndromesCompletedNCT00001438Phase 2
• Psychosocial Correlates and Coping Strategies Associated With Long-Term Survival of HIV-Infected ChildrenCompletedNCT00001435
• Evaluation and Natural History of Children With Cancer and AIDSCompletedNCT00001424
• Phase I Protocol for the Evaluation of the Safety and Immunogenicity of Vaccination With Synthetic HIV Envelope Peptides in Patients With Early Human Immunodeficiency Virus InfectionCompletedNCT00001386Phase 1
• In Vitro Studies of Immunological and Stem Cell Function in Peripheral Blood Mononuclear Cells in PatientsCompletedNCT00001336
• A Randomized Pilot Study for the Treatment of AIDS or AIDS Related Complex With an Alternating or Simultaneous Combination Regimen of AZT and 2',3'-DideoxyinosineCompletedNCT00001267Phase 3
• Studies of the Immune Response in Normal Subjects and Patients With Disorders of the Immune SystemCompletedNCT00001158