National Cancer Institute (NCI): Graft vs Host Disease trials

The registry lists 16 Graft vs Host Disease studies with National Cancer Institute (NCI) as lead sponsor. 1 are open to participants now and 9 have results posted.

Phase 1 4Phase 2 11Phase 3 1No phase 3(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)RecruitingNCT05531786Phase 1/2
• Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell TransplantationCompletedNCT02759731Phase 1/2Results posted
• Vismodegib in Treating Patients With Steroid-Refractory Chronic Graft-Versus-Host DiseaseTerminatedNCT02337517Phase 2Results posted
• Biomarkers in Acute Graft-Versus-Host Disease and Extracorporeal Photopheresis Added to Investigator Chosen Therapies of Steroid Refractory Acute GVHDTerminatedNCT02322190Phase 2Results posted
• Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological MalignanciesCompletedNCT01789255Phase 2Results posted
• Pomalidomide for Chronic Graft-versus-Host DiseaseCompletedNCT01688466Phase 2Results posted
• Clobetasol for Oral Graft-Versus-Host DiseaseCompletedNCT01557517Phase 2Results posted
• Low-Intensity Stem Cell Transplantation With Multiple Lymphocyte Infusions to Treat Advanced Kidney CancerCompletedNCT00923845Phase 2Results posted
• Imatinib Mesylate to Treat Skin Changes in Patients With Chronic Graft-Versus-Host DiseaseCompletedNCT00702689Phase 2Results posted
• Montelukast to Treat Bronchiolitis ObliteransCompletedNCT00656058Phase 2Results posted
• Pediatric cGVHD Symptom ScaleActive, not recruitingNCT04044365
• Optimizing PTCy Dose and TimingActive, not recruitingNCT03983850Phase 1/2
• Collection of Saliva and/ or Peripheral Blood From Healthy Volunteers for ResearchCompletedNCT01851382
• Development and Validation of a Symptom Scale for Children With Chronic Graft-versus-Host DiseaseCompletedNCT01036958
• Donor Th2 Cells to Prevent Graft-Versus-Host Disease in Bone Marrow TransplantsCompletedNCT00001830Phase 1
• Active Immunization of Sibling Bone Marrow Transplant Donors Against Purified Myeloma Protein of the Recipient Undergoing Allogeneic Bone Marrow TransplantationCompletedNCT00001561Phase 3