Tyrosine Kinase Inhibitors: all 10,469 studies that test it

Page 39 of 105. Open to participants first (1,907), then studies with results posted, then the rest; newest registration first within each.

• Multiple Ascending Dose of BMS-911543TerminatedNCT01236352Phase 1/2Results posted
• A Study to Evaluate Pazopanib as an Adjuvant Treatment for Localized Renal Cell Carcinoma (RCC)CompletedNCT01235962Phase 3Results posted
• Phase III Trial Comparing Capecitabine in Combination With Sorafenib or Placebo in the Treatment of Locally Advanced or Metastatic HER2-Negative Breast CancerCompletedNCT01234337Phase 3Results posted
• Bosutinib For Autosomal Dominant Polycystic Kidney DiseaseCompletedNCT01233869Phase 2Results posted
• AMG 102 and Erlotinib for Advanced Non-Small Cell Lung CancerCompletedNCT01233687Phase 1/2Results posted
• A Study of Dovitinib Versus Sorafenib in Adult Patients With Hepatocellular Carcinoma (HCC) as a First Line TreatmentCompletedNCT01232296Phase 2Results posted
• A Study of Tarceva (Erlotinib) in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Following 4 Cycles of Platinum-based Chemotherapy Without Disease ProgressionCompletedNCT01230710Phase 4Results posted
• Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II Study of AZD6244 With Erlotinib in Mutant KRAS Adva...CompletedNCT01229150Phase 2Results posted
• Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary CancersTerminatedNCT01229111Phase 2Results posted
• Efficacy and Safety of Pazopanib Monotherapy After First-line Chemotherapy in Ovarian, Fallopian Tube, or Primary Peritoneal Cancer in Asian WomenCompletedNCT01227928Phase 2Results posted
• CMR Rate of Newly Diagnosed CML-CP Patients Treated With NilotinibCompletedNCT01227577Phase 4Results posted
• Nintedanib in Treating Patients With Recurrent or Persistent Endometrial CancerCompletedNCT01225887Phase 2Results posted
• Study of BMS-754807 Combined With Letrozole or BMS-754807 Alone in Patients With Hormone Receptor-Positive Breast Cancer and Resistance to Non-Steroidal Aromatase InhibitorsTerminatedNCT01225172Phase 2Results posted
• Study of Dovitinib Versus Sorafenib in Patients With Metastatic Renal Cell CarcinomaCompletedNCT01223027Phase 3Results posted
• Selumetinib and Erlotinib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Pancreatic CancerCompletedNCT01222689Phase 2Results posted
• Dasatinib Combination Therapy With the Smoothened (SMO) Inhibitor BMS-833923 in Chronic Myeloid Leukemia (CML)CompletedNCT01218477Phase 1/2Results posted
• Efficacy and Safety Study of PCI-32765 Combine With Ofatumumab in CLLCompletedNCT01217749Phase 1/2Results posted
• Safety and Efficacy Study of PLX3397 in Adults With Relapsed or Refractory Hodgkin LymphomaCompletedNCT01217229Phase 2Results posted
• A Pharmacokinetic and Randomized Trial of Neoadjuvant Treatment With Anastrozole Plus AZD0530 in Postmenopausal Patients With Hormone Receptor Positive Breast CancerCompletedNCT01216176Phase 1/2Results posted
• BIBW 2992 (Afatinib) and Vinorelbine in Japanese Patients With Advanced Solid TumoursCompletedNCT01214616Phase 1Results posted
• Axitinib For The Treatment Of Advanced Hepatocellular CarcinomaCompletedNCT01210495Phase 2Results posted
• Cediranib Maleate With or Without Lenalidomide for the Treatment of Thyroid CancerCompletedNCT01208051Phase 1/2Results posted
• Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorCompletedNCT01207492Phase 2Results posted
• Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL)CompletedNCT01207440Phase 2Results posted
• An Open Label Phase I Dose Escalation Trial of Intravenous BI 6727 (Volasertib)in Combination With Oral BIBW 2992 (Afatinib) in Patients With Advanced Solid TumoursCompletedNCT01206816Phase 1Results posted
• Endocrine Therapy + OSI-906 With or Without Erlotinib for Hormone-Sensitive Metastatic Breast CancerTerminatedNCT01205685Phase 2Results posted
• VEG113971: An Open-Label Study of the Effects of Ketoconazole or Esomeprazole on Pazopanib PKCompletedNCT01205230Phase 4Results posted
• A Study of Erlotinib [Tarceva] as Monotherapy or Intermittent Dosing With Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer. (TALISMAN)CompletedNCT01204697Phase 2Results posted
• Efficacy, Safety, Tolerability of Gefitinib as 1st Line in Caucasian Patients With EGFR Mutation Positive Advanced NSCLCCompletedNCT01203917Phase 4Results posted
• Safety and Efficacy of AZD4547 in Combination With Fulvestrant vs. Fulvestrant Alone in ER+ Breast Cancer PatientsCompletedNCT01202591Phase 1/2Results posted
• Erlotinib in Treating Patients With Recurrent or Metastatic Skin Squamous Cell CarcinomaCompletedNCT01198028Phase 2Results posted
• Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate and Have Had Inadequate Response to Single TNF-alpha AntagonistCompletedNCT01197755Phase 3Results posted
• Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Disease Modifying Anti-rheumatic Drug (DMARD) But Not Responding.CompletedNCT01197534Phase 3Results posted
• Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Not Responding.CompletedNCT01197521Phase 3Results posted
• Saracatinib and Paclitaxel in Platinum-resistant Ovarian CancerCompletedNCT01196741Phase 2/3Results posted
• A Study of Tarceva (Erlotinib) in Elderly Patients With Advanced Non-Small Cell Lung CancerCompletedNCT01196078Phase 4Results posted
• Preoperative Trial of Sorafenib in Combination With Cisplatin Followed by Paclitaxel for Early Stage Breast CancerTerminatedNCT01194869Phase 2Results posted
• Erlotinib Hydrochloride and Radiation Therapy in Stage III-IV Squamous Cell Cancer of the Head and NeckTerminatedNCT01192815Phase 2Results posted
• Erlotinib Re-Challenge for Recurrent EGFR-mutant Lung Cancer in Patients Who Previously Received Adjuvant Erlotinib or GefitinibTerminatedNCT01189435Phase 2Results posted
• Evaluate Safety and Tolerability in Dose Escalation of Sorafenib in Advanced Renal Cell CancerCompletedNCT01189370Phase 2Results posted
• A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis PatientsCompletedNCT01187901Phase 2Results posted
• A Study To Evaluate The Effects And Safety Of Treatment, Treatment Withdrawal, Followed By Re-Treatment With CP-690,550 In Subjects With Moderate To Severe Chronic Plaque PsoriasisCompletedNCT01186744Phase 3Results posted
• A Study in Participants With Rheumatoid Arthritis on Background Methotrexate TherapyCompletedNCT01185353Phase 2Results posted
• Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck CancerCompletedNCT01185171Phase 2Results posted
• Expanded Phase I Pazopanib and Everolimus in Advanced Solid Tumors and Previously Treated Advanced Urothelial CancerCompletedNCT01184326Phase 1Results posted
• A Study of Tarceva (Erlotinib) to Compare Two Different Doses in in Currently Smoking Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (CURRENTS)CompletedNCT01183858Phase 3Results posted
• A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by SurgeryCompletedNCT01183559Phase 1Results posted
• Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG)TerminatedNCT01182350Phase 2Results posted
• Erlotinib Plus Bevacizumab in Hepatocellular Carcinoma (HCC) as Second-line TherapyCompletedNCT01180959Phase 2Results posted
• Efficacy, Safety, Tolerability and Pharmacokinetics (PK) of Nilotinib (AMN107) in Pulmonary Arterial Hypertension (PAH)TerminatedNCT01179737Phase 2Results posted
• An Extension Protocol for Subjects Who Were Previously Enrolled in Other Tivantinib (ARQ 197) ProtocolsCompletedNCT01178411Phase 1/2Results posted
• A Study on the Correlation Between Tarceva (Erlotinib) - Induced Rash and Efficacy in EGFR Mutated Participants With Advanced Non-Small Cell Lung Cancer Receiving First-Line TherapyCompletedNCT01174563Phase 2Results posted
• A Two Arm Trial of Axitinib and Carboplatin/Paclitaxel in MelanomaCompletedNCT01174238Phase 2Results posted
• Pilot Study of Erlotinib for the Treatment of Patients With de Novo Acute Myeloid LeukemiaCompletedNCT01174043Phase 2Results posted
• Dasatinib With Fludarabine and Rituximab in Relapsed and Refractory CLL and SLLTerminatedNCT01173679Phase 2Results posted
• A Phase Ib Expansion Study Investigating the Safety, Efficacy, and Pharmacokinetics of Intravenous CUDC-101 in Subjects With Advanced Head and Neck, Gastric, Breast, Liver and Non-small Cell Lung Cancer TumorsCompletedNCT01171924Phase 1Results posted
• Roll Over Study From 1199.30 BIBF 1120 in Idiopathic Pulmonary Fibrosis (IPF)CompletedNCT01170065Phase 2Results posted
• BIBW 2992 (Afatinib) in Combination With Pemetrexed in Advanced Solid TumoursCompletedNCT01169675Phase 1Results posted
• A Phase 1 Absolute Bioavailability Study For Oral Crizotinib In Healthy VolunteersCompletedNCT01168934Phase 1Results posted
• Nilotinib in the Treatment of Systemic SclerosisCompletedNCT01166139Phase 2Results posted
• Effects of Tofacitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA)CompletedNCT01164579Phase 2Results posted
• Sunitinib Malate With or Without Gemcitabine Hydrochloride in Treating Patients With Advanced Kidney Cancer That Cannot Be Removed By SurgeryCompletedNCT01164228Phase 2Results posted
• Chemoembolization of the Liver With or Without Sunitinib Malate in Treating Patients With Liver CancerCompletedNCT01164202Phase 2/3Results posted
• A Long Term Study To Evaluate The Safety And Tolerability Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque PsoriasisTerminatedNCT01163253Phase 3Results posted
• A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast CancerCompletedNCT01160211Phase 3Results posted
• Pazopanib Hydrochloride Before Surgery in Treating Patients With Kidney CancerCompletedNCT01158521Phase 2Results posted
• Sunitinib Malate in Treating Patients With Previously Untreated Metastatic Kidney CancerCompletedNCT01158222Phase 2Results posted
• Pazopanib Hydrochloride in Treating Patients With Stage IV Kidney CancerCompletedNCT01157091Phase 2Results posted
• Everolimus and OSI-906 for Patients With Refractory Metastatic Colorectal CancerCompletedNCT01154335Phase 1Results posted
• Bioequivalence And Food Effect Study Comparing The Commercial Formulation Of Crizotinib To Its Clinical Study Formulations And Commercial Formulation With Or Without Food In Healthy VolunteersCompletedNCT01154218Phase 1Results posted
• A Study to Assess Biomarkers Impact on Participants Response to Erlotinib Treatment for First-line Non-Small Cell Lung Cancer With Endothelial Growth Factor Receptor (EGFR) Activating MutationsCompletedNCT01153984Phase 2Results posted
• A Study of BIBW 2992 (Afatinib) in Patients With Metastatic Colorectal CancerCompletedNCT01152437Phase 2Results posted
• Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHTCompletedNCT01151852Phase 3Results posted
• Study of Anastrozole +/- AZD8931 in Postmenopausal Women With Endocrine Therapy Naive Breast CancerTerminatedNCT01151215Phase 2Results posted
• Estimation Of Effect Of Ketoconazole On Pharmacokinetics Of Crizotinib In Healthy VolunteersCompletedNCT01149785Phase 1Results posted
• Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or K-RAS Mutant Colon CancersTerminatedNCT01149434Phase 1/2Results posted
• Pazopanib Versus Sunitinib in the Treatment of Asian Subjects With Locally Advanced and/or Metastatic Renal Cell CarcinomaCompletedNCT01147822Phase 2Results posted
• Estimation Of Effect Of Rifampin On Pharmacokinetics Of Crizotinib In Healthy VolunteersCompletedNCT01147055Phase 1Results posted
• Study of Platelet Derived Growth Factor Receptor (PDGFR) in Recurrent Malignant GliomasCompletedNCT01140568Phase 2Results posted
• Pilot Study of Gleevec/Imatinib Mesylate (STI-571, NSC 716051) in Neurofibromatosis (NF1) Patient With Plexiform NeurofibromasCompletedNCT01140360Phase 1/2Results posted
• A Study in Subjects With Recurrent Malignant GliomaCompletedNCT01137604Phase 2Results posted
• An Open-Label, 2-Cohort, Multicenter, Study of Lenvatinib in Previously Treated Subjects With Unresectable Stage III or Stage IV MelanomaCompletedNCT01136967Phase 2Results posted
• A Study of E7080 Alone, and in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Renal Cell Carcinoma Following One Prior Vascular Endothelial Growth Factor (VEGF)-Targeted TreatmentCompletedNCT01136733Phase 1/2Results posted
• Safety and PK Study of BIBF 1120 in Japanese Patients With IPFCompletedNCT01136174Phase 2Results posted
• A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye DiseaseCompletedNCT01135511Phase 2Results posted
• A Study of Avastin (Bevacizumab) in Combination With Xelox and Tarceva in Patients With Metastatic Colorectal Cancer.CompletedNCT01135498Phase 2Results posted
• Dose Ranging Study of Pazopanib to Treat Neovascular Age-Related Macular DegenerationCompletedNCT01134055Phase 2Results posted
• E7080 (Lenvatinib) in Combination With Dacarbazine Versus Dacarbazine Alone as First Line Therapy in Patients With Stage IV MelanomaCompletedNCT01133977Phase 1/2Results posted
• E7080 in Combination With Carboplatin + Gemcitabine Versus Carboplatin + Gemcitabine Alone as Second Line Therapy in Patients With Platinum-Sensitive Recurrent Ovarian Cancer by CA125TerminatedNCT01133756Phase 1/2Results posted
• Cediranib Maleate in Treating Patients With Recurrent or Persistent Endometrial CancerCompletedNCT01132820Phase 2Results posted
• Study of Nilotinib in Ph+ CML-CP Patients With Low Imatinib Trough Plasma ConcentrationsTerminatedNCT01131325Phase 4Results posted
• A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell CancerCompletedNCT01130519Phase 2Results posted
• A Study Of Neratinib (HKI-272) And Capecitabine In Japanese With Solid TumorCompletedNCT01128842Phase 1Results posted
• Lapatinib in Combination With VinorelbineCompletedNCT01128543Phase 2Results posted
• LUX-Breast 1: BIBW 2992 (Afatinib) in HER2-positive Metastatic Breast Cancer Patients After One Prior Herceptin TreatmentCompletedNCT01125566Phase 3Results posted
• Studying An Investigational Drug Crizotinib (PF-02341066) In Non Non-Small Cell Lung Cancer Tumors That Are Positive For Anaplastic Lymphoma Kinase (ALK)TerminatedNCT01121588Phase 1Results posted
• A Study Of Combined C- MET Inhibitor And PAN-HER Inhibitor (PF-02341066 And PF-00299804) In Patients With Non- Small Cell Lung CancerCompletedNCT01121575Phase 1Results posted
• Efficacy And Safety Of Sunitinib In Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine TumorsCompletedNCT01121562Phase 2Results posted
• BIBW 2992 (Afatinib) vs Gemcitabine-cisplatin in 1st Line Non-small Cell Lung Cancer (NSCLC)CompletedNCT01121393Phase 3Results posted
• GCC 0845:Vorinostat and Lapatinib in Advanced Solid Tumors and Advanced Breast Cancer to Evaluate Response and BiomarkersTerminatedNCT01118975Phase 1/2Results posted

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