Drug
Selpercatinib clinical trials
Also written LOXO-292, LY3527723 and Retevmo.
- studies test it
- 30
- open now
- 5
- in phase 3
- 3
- first study started
- 2016
Keep track of what changes. Save the selpercatinib studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Studies by the year they started
30 studies that test it; most in 2021 (6)
| Year | Studies |
|---|---|
| 2016 | 1 |
| 2017 | 2 |
| 2018 | 5 |
| 2019 | 4 |
| 2020 | 5 |
| 2021 | 6 |
| 2022 | 2 |
| 2023 | 2 |
| 2025 | 1 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 15
- Phase 2
- 11
- Phase 3
- 3
- Phase 4
- 2
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 20 · Other 10
Eli Lilly and Company (15) · Loxo Oncology, Inc. (5) · National Cancer Institute (NCI) (2) · SWOG Cancer Research Network (2) · M.D. Anderson Cancer Center (1) · Fondazione per la Medicina Personalizzata (1) · University of Oklahoma (1) · Fujian Medical University (1)
Often tested with
Tested in the same studies.
Palbociclib (3) · Vemurafenib (3) · Erdafitinib (2) · Larotrectinib (2) · Olaparib (2) · Erlotinib (2) · Trastuzumab (2) · Pertuzumab (2)
Studies
Open first, then newest update. How each study uses selpercatinib is read from its arms, and is right about nine times in ten.
Testing it · 30
- A Study of Selpercatinib (LY3527723) in Participants With Rearranged During Transfection (RET)-Altered Cancers in IndiaNot yet recruitingPhase 4Eli Lilly and CompanyNCT07822880Written as Selpercatinib
- Feasibility Study for Repurposing RET InhibitorsNot yet recruitingEarly Phase 1University of OklahomaNCT07146893Written as Selpercatinib
- Genotype-Driven Neoadjuvant Therapy for Locally Advanced Thyroid Cancer: A Real-World Cohort StudyNot yet recruitingPhase 4Fujian Medical UniversityNCT07010393Written as Selpercatinib
- Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TCRecruitingPhase 2Massachusetts General HospitalNCT05668962Written as Selpercatinib
- The Drug Rediscovery Protocol (DRUP Trial)RecruitingPhase 2The Netherlands Cancer InstituteNCT02925234Written as Selpercatinib
- A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung CancerActive, not recruitingPhase 3Eli Lilly and CompanyNCT04194944Written as Selpercatinib
- Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment TrialActive, not recruitingPhase 2National Cancer Institute (NCI)NCT04320888Written as Selpercatinib
- A Study of Selpercatinib (LY3527723) in Participants With Advanced Solid Tumors Including RET Fusion-positive Solid Tumors, Medullary Thyroid Cancer and Other Tumors With RET ActivationActive, not recruitingPhase 2Eli Lilly and CompanyNCT04280081Written as Selpercatinib
- Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)Active, not recruitingPhase 2National Cancer Institute (NCI)NCT03155620Written as Selpercatinib
- Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid CancerActive, not recruitingPhase 2M.D. Anderson Cancer CenterNCT04759911Written as Selpercatinib
- A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)Active, not recruitingPhase 1/2Eli Lilly and CompanyNCT03157128Written as LOXO-292
- Targeted Treatment for RET Fusion-Positive Advanced Non-Small Cell Lung Cancer (A LUNG-MAP Treatment Trial)Active, not recruitingPhase 2SWOG Cancer Research NetworkNCT04268550Written as Selpercatinib
- A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid CancerActive, not recruitingPhase 3Loxo Oncology, Inc.NCT04211337Written as Selpercatinib
- A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)Active, not recruitingPhase 3Eli Lilly and CompanyNCT04819100Written as Selpercatinib
- A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) TumorsActive, not recruitingPhase 1/2Eli Lilly and CompanyNCT03899792Written as Selpercatinib
- A Study of Effects of Selpercatinib (LY3527723) on Repaglinide in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT05469113Written as Selpercatinib
- A Study of Effects of Selpercatinib (LY3527723) on Midazolam in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT05338476Written as Selpercatinib
- A Study of Effect of Food and a Proton Pump Inhibitor on Selpercatinib (LY3527723) in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT05468164Written as Selpercatinib
- A Study of Effect of Selpercatinib (LY3527723) on Corrected QT (QTc) Interval in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT05630274Written as Selpercatinib
- A Study of Effect of Selpercatinib (LY3527723) in Participants With Normal and Impaired Renal FunctionCompletedPhase 1Eli Lilly and CompanyNCT05469100Written as Selpercatinib
See all 30 studies that test selpercatinib →
Given in every arm · 3 — selpercatinib is usual care beside what is tested
- A Study of Effects of Itraconazole and Rifampin on Selpercatinib (LY3527723) in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT05338489Written as Selpercatinib
- Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)Active, not recruitingPhase 2AstraZenecaNCT03944772Written as Selpercatinib
- Study of H2 Antagonist and a Proton Pump Inhibitor of Selpercatinib in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT05338502Written as Selpercatinib
Codes
What other systems call selpercatinib · ClinicalTrials.gg INT001233
- MeSH (NLM) C000656166selpercatinibConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) CEGM9YBNGDSELPERCATINIBConfirmed FDA, NLM, Wikidata
- RxNorm 2370147One source FDA
- Wikidata Q96405266selpercatinibConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C134987SelpercatinibOne source FDA
- DrugBank DB15685One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C000656166 | selpercatinib | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | CEGM9YBNGD | SELPERCATINIB | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2370147 | — | One source FDA |
| Wikidata | Q96405266 | selpercatinib | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C134987 | Selpercatinib | One source FDA |
| DrugBank | DB15685 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.