Drug
Rivaroxaban clinical trials
Also written Xarelto, BAY 59-7939 and JNJ-39039039.
How each study uses Rivaroxaban is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Rivaroxaban studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Approvals
The first approval found in each region, with its record
- United States
- 1 Jul 2011 · XARELTO · NDA 022406 (FDA, Drugs@FDA)
- European Union
- 30 Sept 2008 · Xarelto · EMEA/H/C/000944 (EMA)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Name
Studies by the year they started
306 studies that test it; most in 2020 (28); 1 more planned to start later
| Year | Studies |
|---|---|
| 2002 | 1 |
| 2004 | 6 |
| 2005 | 1 |
| 2006 | 7 |
| 2007 | 5 |
| 2008 | 2 |
| 2009 | 2 |
| 2010 | 5 |
| 2011 | 4 |
| 2012 | 12 |
| 2013 | 19 |
| 2014 | 17 |
| 2015 | 26 |
| 2016 | 19 |
| 2017 | 17 |
| 2018 | 14 |
| 2019 | 14 |
| 2020 | 28 |
| 2021 | 25 |
| 2022 | 19 |
| 2023 | 22 |
| 2024 | 19 |
| 2025 | 14 |
| 2026 | 8 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 77 · Other 230
Bayer (45) · Janssen Research & Development, LLC (8) · Ottawa Hospital Research Institute (7) · Insel Gruppe AG, University Hospital Bern (6) · Assistance Publique - Hôpitaux de Paris (6) · Janssen Scientific Affairs, LLC (5) · Population Health Research Institute (5) · Ottawa Heart Institute Research Corporation (4)
Often tested with
Tested in the same studies.
Apixaban (33) · Aspirin (26) · Dabigatran (21) · Warfarin (17) · Edoxaban (12) · Enoxaparin (11) · Clopidogrel (9) · Ticagrelor (6)
Related medicines
As reviewed, each with the page that says it.
- One of Factor Xa inhibitors source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 27, 7 in phase 3
Studies that test Rivaroxaban, phase 3 first.
- Dec 2026Primary Thromboprophylaxis in Patients With Malignancy and Central Venous CathetersPhase 3 · Ottawa Hospital Research Institute
- Jan 2027Chronic Anticoagulation With a Reduced Dose Regimen of Rivaroxaban in End-stage Renal Disease PatientsPhase 3 · University Hospital, Tours
- Jan 2027Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular AtherostenosisPhase 3 · University of Florida
- Mar 2027ENhanced Recovery and ABbreviated LEngth of Anticoagulation for Thromboprophylaxis After Primary Hip ArthroplastyPhase 3 · Prof. Stavros Konstantinides, MD
- Apr 2027Rivaroxaban vs Warfarin in Patients With Mechanical Heart ValvesPhase 3 · Rawalpindi Institute of Cardiology
- Jul 2027Hip Fracture Surgery Arterial and Venous Thrombotic Events PreventionPhase 3 · McMaster University
- Sep 2027Aspirin or Rivaroxaban Thromboprophylaxis for Patients With Multiple MyelomaPhase 3 · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Nov 2026To Evaluate The Efficacy And Safety Of Rivaroxaban In Combination With Aspirin Compared With Aspirin Monotherapy In Patients With Stable Coronary Artery Disease (CAD) and High Ischemic RiskNot applicable · Republican Specialized Scientific and Practical Medical Center of Cardiology
- Dec 2026Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in Patients With Liver CirrhosisPhase 1 · Insel Gruppe AG, University Hospital Bern
- Dec 2026NOAC Therapy Guided by PARIS Risk Score and D-dimer in Patients With ACS After PCIPhase 4 · China National Center for Cardiovascular Diseases
Studies
Open first, then newest update. How each study uses Rivaroxaban is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 307
- VTE Prevention With Rivaroxaban in Genitourinary Cancer Patients Receiving Systemic TherapyRecruitingPhase 2/3Ottawa Hospital Research InstituteNCT05920343Written as Rivaroxaban 10 MG
- To Evaluate The Efficacy And Safety Of Rivaroxaban In Combination With Aspirin Compared With Aspirin Monotherapy In Patients With Stable Coronary Artery Disease (CAD) and High Ischemic RiskNot yet recruitingNot applicableRepublican Specialized Scientific and Practical Medical Center of CardiologyNCT07928583Written as rivaroxaban plus aspirin
- Anti-inflammatory and Anti-thrombotic Therapy With colcHicine and Low Dose Rivaroxaban for Major Adverse Cardiovascular Events Reduction in Ischemic StrokeNot yet recruitingPhase 4Brazilian Clinical Research InstituteNCT06396858Written as Rivaroxaban 2.5 Mg Oral Tablet
- Aspirin vs. Rivaroxaban for Thromboprophylaxis in Multiple MyelomaRecruitingPhase 4Chen LijuanNCT07907211Written as Rivaroxaban
- Model-informed Dose Optimization for Rivaroxaban in Children With Giant Coronary Artery Aneurysm After Kawasaki DiseaseRecruitingPhase 4Children's Hospital of Fudan UniversityNCT06978439Written as Rivaroxaban (Xarelto)
- Comparison of DOACs and LMWH for Thromboprophylaxis After Total Knee ArthroplastyRecruitingNot applicableMilitary Hospital of TunisNCT07869615Written as Rivaroxaban
- HIP Fracture Oral thromboPROphylaxis (Hip PRO Pilot)RecruitingPhase 2University of CalgaryNCT05775965Written as Rivaroxaban 10mg
- COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial FibrillationRecruitingPhase 4Ottawa Hospital Research InstituteNCT04642430Written as Rivaroxaban
- Comparing the Safety and Efficacy of Apixaban and RivaroxabanRecruitingPhase 4VA Office of Research and DevelopmentNCT06953726Written as Rivaroxaban
- Comparison of Aspirin Alone Versus Low-Dose Rivaroxaban Plus Aspirin in Chronic Limb-Threatening IschemiaRecruitingEarly Phase 1King Edward Medical UniversityNCT07832578Written as Low-Dose Rivaroxaban Plus Aspirin,
- Rivaroxaban vs Enoxaparin After Cesarean Section: Laboratory Thromboprophylaxis OutcomesRecruitingNot applicableWolfson Medical CenterNCT07820670Written as Rivaroxaban
- Personalizing Thromboprophylaxis for Patients With Peripheral Artery DiseaseRecruitingNot applicableMassachusetts General HospitalNCT07613840Written as Rivaroxaban
- Comparison of Clopidogrel-based Antiplatelet Agent Treatment and Aspirin Plus Low Dose Rivaroxaban TherapyRecruitingPhase 4Seoul National University Bundang HospitalNCT07796217Written as Aspirin and low-dose rivaroxaban
- Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe (CATIS- ICAS)Not yet recruitingPhase 3Population Health Research InstituteNCT07468448Written as Rivaroxaban
- Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in Patients With Liver CirrhosisRecruitingPhase 1Insel Gruppe AG, University Hospital BernNCT04874428Written as Rivaroxaban 10 mg Oral Tablet
- NOAC Therapy Guided by PARIS Risk Score and D-dimer in Patients With ACS After PCIRecruitingPhase 4China National Center for Cardiovascular DiseasesNCT05638867Written as Aspirin + Clopidogrel + Rivaroxaban
- Impact of Bromocriptine on Clinical Outcomes for Peripartum CardiomyopathyRecruitingPhase 4Dennis M. McNamara, MD, MSNCT05180773Written as Rivaroxaban
- Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve ReplacementRecruitingPhase 4Joon Bum KimNCT04258488Written as Rivaroxaban Oral Tablet
- Rivaroxaban for Children Aged Over 2 Years With Giant Coronary Artery Aneurysms After Kawasaki DiseaseRecruitingPhase 4Children's Hospital of Fudan UniversityNCT05643651Written as Rivaroxaban Oral Tablet [Xarelto]
- Thromboprophylaxis in Lower Limb ImmobilisationRecruitingPhase 3Queen Mary University of LondonNCT06370273Written as Rivaroxaban
See all 307 studies that test Rivaroxaban →
Given beside what is tested · 14 — Rivaroxaban is usual care or a partner of the new treatment
- Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery DiseaseRecruitingPhase 3Regeneron PharmaceuticalsNCT07318610Written as Rivaroxaban
- Effects of VMX-C001 on the Anticoagulant Effect of Different Forms of HeparinCompletedPhase 1VarmX B.V.NCT06517563Written as Rivaroxaban
- Phase 2 Study of Rivaroxaban Reversal by Ciraparantag as Measured by WBCTCompletedPhase 2Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.NCT03172910Written as Rivaroxaban
- Study of Intravenous VMX-C001 in Healthy Subjects and in Combination With Selected Direct Oral Anticoagulants in Healthy Older SubjectsCompletedPhase 1VarmX B.V.NCT05152420Written as Rivaroxaban
- A Healthy Volunteer Pharmacokinetics (PK)/Pharmacodynamics (PD), Safety and Tolerability Study of Andexanet in Healthy Japanese and Caucasian SubjectsCompletedPhase 2Portola PharmaceuticalsNCT03310021Written as Rivaroxaban
- Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 2 of 4)CompletedPhase 2Portola PharmaceuticalsNCT03578146Written as PRT064445/Rivaroxaban
- Combined Topical Tranexamic Acid With Floseal® in Total Knee ArthroplastyCompletedPhase 4Chang Gung Memorial HospitalNCT03328832Written as rivaroxaban (10mg)
- Rivaroxaban With Diosmin in Long-term Treatment of Deep Vein ThrombosisCompletedPhase 4Pirogov Russian National Research Medical UniversityNCT03413618Written as Rivaroxaban
- Rivaroxaban Hypericum TrialCompletedPhase 1Insel Gruppe AG, University Hospital BernNCT03796377Written as Rivaroxaban
- DUAL Antithrombotic Therapy in Patients With AF and ACSStatus unknownPhase 4Second Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT04023630Written as Rivaroxaban 15 MG Oral Tablet
- A Study to Assess the Effects of 2 Different Prothrombin Complex Concentrates on the Pharmacodynamics of Rivaroxaban in Healthy Adult VolunteersCompletedPhase 1Janssen Research & Development, LLCNCT01656330Written as Rivaroxaban 20 mg twice daily
- A Study to Explore the Pharmacodynamic Changes When Transitioning From Rivaroxaban to Warfarin in Healthy VolunteersCompletedPhase 1Janssen Research & Development, LLCNCT01400646Written as Rivaroxaban
- The Blood Saving Effect of Tranexamic Acid in Total Knee Arthroplasty With Rivaroxaban as ThromboprophylaxisCompletedPhase 4Chang Gung Memorial HospitalNCT02458729Written as rivaroxaban (10mg)
- Comparison of Topical and Infusion Tranexamic Acid After Total Knee ArthroplastyStatus unknownPhase 4Chang Gung Memorial HospitalNCT02453802Written as rivaroxaban (10mg)
As the comparator · 14 — what is tested is compared with Rivaroxaban
- Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus BacteremiaRecruitingPhase 4McGill University Health Centre/Research Institute of the McGill University Health CentreNCT06650501Written as Rivaroxaban
- A Pilot Trial Comparing Full Dose Rivaroxaban to Prophylactic Dose Rivaroxaban in Patients With Superficial Vein Thrombosis in the LegRecruitingPhase 2/3Ottawa Hospital Research InstituteNCT06965998Written as Low dose rivaroxaban
- Bleeding Risk With Apixaban Versus Rivaroxaban in Acute Pulmonary EmbolismCompletedNot applicableCombined military hospital lahoreNCT07774273Written as Drug: Rivaroxaban
- VTE Prevention Following Total Hip and Knee ArthroplastyCompletedPhase 3Sudeep ShivakumarNCT04075240Written as Rivaroxaban 10 MG and acetylsalicylic acid 81 mg
- Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical TherapyCompletedPhase 4Charite University, Berlin, GermanyNCT03463317Written as Rivaroxaban
- Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial FibrillationActive, not recruitingPhase 2Anthos Therapeutics, Inc.NCT04755283Written as Rivaroxaban
- A Study to Evaluate the Efficacy and Safety of SHR-2004 Injection in Preventing Postoperative Venous Thromboembolism in Patients Undergoing Ovarian Cancer SurgeryCompletedPhase 2Beijing Suncadia Pharmaceuticals Co., LtdNCT06220123Written as Enoxaparin Sodium Injection; Rivaroxaban Tablets
- Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult ParticipantsCompletedPhase 1Regeneron PharmaceuticalsNCT06444178Written as Rivaroxaban
- Tinzaparin Lead-In to Prevent the Post-Thrombotic SyndromeTerminatedPhase 4Sunnybrook Health Sciences CentreNCT04794569Written as Rivaroxaban
- Efficacy and Safety of Apixaban in COVID-19 Coagulopathy Patients With Respiratory Severity Under Critical CareStatus unknownPhase 2Scotmann PharmaceuticalsNCT05088928Written as Rivaroxaban
- Better Adherence With New Oral Anticoagulant in Atrial Fibrillation : Effectiveness of a Personalized Education ProgramCompletedNot applicableUniversity Hospital, MontpellierNCT02422602Written as Xarelto
- Rivaroxaban for the Treatment of Symptomatic Isolated Distal Deep Vein ThrombosisStatus unknownPhase 3Walter AgenoNCT02722447Written as rivaroxaban
- Evaluation of WATCHMAN Left Atrial Appendage Occlusion Device in Patients With Atrial Fibrillation Versus RivaroxabanStatus unknownPhase 4Shulin WuNCT02549963Written as Rivaroxaban
- Single IV Administration of TB-402 for Prophylaxis of Venous Thromboembolic Events (VTE) After Total Hip Replacement SurgeryCompletedPhase 2ThromboGenicsNCT01344954Written as Rivaroxaban
What changed recently
From the registry's own updates since Oct 15, 2026.
Newly registered2
- To Evaluate The Efficacy And Safety Of Rivaroxaban In Combination With Aspirin Compared With Aspirin Monotherapy In Patients With Stable Coronary Artery Disease (CAD) and High Ischemic RiskNov 10, 2026NCT07928583
- Aspirin vs. Rivaroxaban for Thromboprophylaxis in Multiple MyelomaOct 30, 2026NCT07907211
Codes
What other systems call Rivaroxaban · ClinicalTrials.gg INT006609
- MeSH (NLM) D000069552RivaroxabanConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 9NDF7JZ4M3RIVAROXABANConfirmed FDA, NLM, Wikidata
- RxNorm 1114195Confirmed FDA, Wikidata
- Wikidata Q420262rivaroxabanConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C77995RivaroxabanOne source FDA
- DrugBank DB06228One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000069552 | Rivaroxaban | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 9NDF7JZ4M3 | RIVAROXABAN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1114195 | — | Confirmed FDA, Wikidata |
| Wikidata | Q420262 | rivaroxaban | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C77995 | Rivaroxaban | One source FDA |
| DrugBank | DB06228 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.