Drug
Pyrimethamine clinical trials
Also written Daraprim.
- studies test it
- 34
- open now
- 4
- in phase 3
- 8
- first study started
- 2000
Keep track of what changes. Save the Pyrimethamine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Combined with it in one product
Studies by the year they started
28 studies that test it; most in 2003 (4)
| Year | Studies |
|---|---|
| 2000 | 1 |
| 2002 | 1 |
| 2003 | 4 |
| 2004 | 1 |
| 2005 | 2 |
| 2006 | 2 |
| 2008 | 1 |
| 2009 | 3 |
| 2010 | 2 |
| 2015 | 1 |
| 2017 | 2 |
| 2018 | 1 |
| 2019 | 3 |
| 2023 | 1 |
| 2024 | 2 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 16
- Phase 2
- 10
- Phase 3
- 8
- Phase 4
- 6
- No phase
- 2
What it is tested for
Each study’s main condition, where its own words name it.
- Malaria
- 11
Who runs them
Industry 4 · Other 30
National Institute of Allergy and Infectious Diseases (NIAID) (11) · London School of Hygiene and Tropical Medicine (4) · Erasmus Medical Center (3) · Washington University School of Medicine (1) · Dana-Farber Cancer Institute (1) · Bristol-Myers Squibb (1) · University of California, San Francisco (1) · GlaxoSmithKline (1)
Often tested with
Tested in the same studies.
Sulfadoxine (11) · Artesunate (5) · Amodiaquine (4) · Sulfadiazine (3) · Lenalidomide (2) · Chloroquine diphosphate (1) · PfSPZ Challenge (1) · Atovaquone (1)
Studies
Open first, then newest update. How each study uses Pyrimethamine is read from its arms, and is right about nine times in ten.
Testing it · 34
- Combining Latency Reversing Agents to Address the HIV ReservoirNot yet recruitingPhase 1/2Erasmus Medical CenterNCT07384624Written as Pyrimethamine (PYR)
- Seasonal Malaria Chemoprevention Rapid Assessment Study MozambiqueNot yet recruitingPhase 4Malaria ConsortiumNCT06337253Written as Sulfadoxine/pyrimethamine plus amodiaquine
- Optimizing Reversal of HIV Latency With Combination TherapyNot yet recruitingPhase 1/2Erasmus Medical CenterNCT06240520Written as Pyrimethamine 200mg Oral Tablet
- Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital ToxoplasmosisRecruitingPhase 4National Institute of Allergy and Infectious Diseases (NIAID)NCT00004317Written as Pyrimethamine
- Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell CarcinomaCompletedEarly Phase 1Washington University School of MedicineNCT05678348Written as Pyrimethamine
- Pyrimethamine for the Treatment of Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaCompletedPhase 1/2Dana-Farber Cancer InstituteNCT01066663Written as pyrimethamine
- Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...CompletedPhase 1/2National Institute of Allergy and Infectious Diseases (NIAID)NCT03952650Written as Pyrimethamine
- A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive PatientsCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT00000973Written as Pyrimethamine
- Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic EncephalitisCompletedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT00000794Written as Pyrimethamine
- Pyrimethamine for Intermediate/High-risk Myelodysplastic Syndromes (MDS)WithdrawnPhase 1Montefiore Medical CenterNCT03057990Written as Pyrimethamine
- Dose Escalation PfSPZ-CVacCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT03083847Written as Pyrimethamine
- LRAs United as a Novel Anti-HIV Strategy.CompletedPhase 1/2Erasmus Medical CenterNCT03525730Written as Pyrimethamine
- An Investigational Study to Determine the Drug Level Profile of BMS-986165 in Healthy Male Volunteers Following Transporter Inhibition.CompletedPhase 1Bristol-Myers SquibbNCT04086719Written as Pyrimethamine
- Longitudinal Antimalarial Combinations in UgandaCompletedPhase 3University of California, San FranciscoNCT00123552Written as Amodiaquine+Sulfadoxine/Pyrimethamine
- Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian SubjectsCompletedPhase 1GlaxoSmithKlineNCT03258762Written as Pyrimethamine
- SP Resistance and Falciparum Malaria TransmissionWithdrawnPhase 3National Institute of Allergy and Infectious Diseases (NIAID)NCT00299247Written as sulfadoxine/pyrimethamine
- Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...CompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT02511054Written as Pyrimethamine (PYR)
- SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)CompletedPhase 1/2Weill Medical College of Cornell UniversityNCT01083667Written as Pyrimethamine
- Comparison of Two Strategies for the Delivery of IPTcCompletedPhase 4London School of Hygiene and Tropical MedicineNCT00376155Written as sulfadoxine /pyrimethamine plus amodiaquine
- IPT and Efficacy of Sulphadoxine/Pyrimethamine and Chlorproguanil/Dapsone in 6-59 Month Old Children With Malaria.TerminatedPhase 3London School of Hygiene and Tropical MedicineNCT00361114Written as sulphadoxine/pyrimethamine
See all 34 studies that test Pyrimethamine →
Given in every arm · 1 — Pyrimethamine is usual care beside what is tested
Codes
What other systems call Pyrimethamine · ClinicalTrials.gg INT008139
- MeSH (NLM) D011739PyrimethamineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) Z3614QOX8WPYRIMETHAMINEConfirmed FDA, NLM, Wikidata
- RxNorm 9010Confirmed FDA, Wikidata
- Wikidata Q421072pyrimethamineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C788PyrimethamineOne source FDA
- DrugBank DB00205One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D011739 | Pyrimethamine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | Z3614QOX8W | PYRIMETHAMINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 9010 | — | Confirmed FDA, Wikidata |
| Wikidata | Q421072 | pyrimethamine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C788 | Pyrimethamine | One source FDA |
| DrugBank | DB00205 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.