Phosphodiesterase Inhibitors: all 583 studies that test it

Page 4 of 6. Open to participants first (87), then studies with results posted, then the rest; newest registration first within each.

• Effects of Combinations of Performance-enhancing Supplements on Exercise PerformanceStatus unknownNCT05354999Not applicable
• Does Caffeine Facilitate Human Reward Learning Behaviors?Active, not recruitingNCT05325502Not applicable
• Pentoxifylline for Treatment of Resistant Major DepressionCompletedNCT05324735Phase 1/2
• PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic HypothermiaWithdrawnNCT05295784Phase 1
• Pentoxifylline in Treatment of Patients With Nonalcoholic SteatohepatitisCompletedNCT05284448Phase 3
• Effects of Caffeine on Anxiety, Emotional Processing, Approach-avoidance Behavior, and Interoception in Panic DisorderCompletedNCT05261594Not applicable
• CaffeinICU Study - A Study on Oral Caffeine in ICU Patients With ComaSuspendedNCT05232734Phase 2
• Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene CitrateCompletedNCT05231980Phase 2
• Caffeine Supplementation, Resistance Training and Blood Antioxidant StatusCompletedNCT05230303Not applicable
• "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"CompletedNCT05189535Phase 2/3
• The Therapeutic Effect of Co-administration of Pentoxifylline and Zinc in Men With Idiopathic AsthenozoospermiaStatus unknownNCT05178953Early Phase 1
• The Effects of Caffeine on Physical Performance of Ice Hockey PlayersCompletedNCT05170139Not applicable
• Effect of Pentoxifylline and Zinc Co-administration in Patients With OligoasthenoteratozoospermiaStatus unknownNCT05156684Not applicable
• Evaluation of the Potential CYP1A2-mediated Drug Drug Interaction Safety, and Tolerability of ABX464CompletedNCT05121714Phase 1
• Pentoxifylline Add-on Therapy for SchizophreniaStatus unknownNCT05073640Phase 1/2
• Comparing the Effects of Vitamin E, Ursodeoxycholic Acid and Pentoxyfylline on Egyptian Non-alcoholic Steatohepatitis (NASH) PatientsCompletedNCT04977661Phase 4
• Delayed-release Bedtime Caffeine and Sleep Inertia Symptoms Immediately Upon AwakeningCompletedNCT04975360Not applicable
• Turning Dexmedetomidine Into a Powerful Anesthetic That Can be Rapidly and Completely ReversedWithdrawnNCT04942340Phase 1
• Follow-up of NAFLD Patients With MRI-PDFFCompletedNCT04910178Phase 4
• Caffeine and the Autonomic Nervous SystemCompletedNCT04886869Not applicable
• Effect of Caffeine on Heart Rate Variability in NewbornsCompletedNCT04869176Not applicable
• Target Weaning Oxygen to Determine Cafffeine Duration for AOPCompletedNCT04868565Phase 4
• Acute Caffeine Ingestion on Futsal PerformanceCompletedNCT04852315Not applicable
• Effect of Pentoxifylline on Prognosis of Coronavirus Disease 2019 (COVID- 19) InfectionCompletedNCT04739345Not applicable
• Caffeine and Cerebrovascular ReactivityCompletedNCT04730193Early Phase 1
• "WakeUp" for Vigilance Following LunchCompletedNCT04685005Not applicable
• Caffeine Ingestion to Counter the Exercise-mediated Fall in Glycaemia in Type 1 DiabetesCompletedNCT04671043Not applicable
• Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral PregabalinCompletedNCT04662125Not applicable
• Estimation of the Effect of Multiple Dose Ritlecitinib (PF-06651600) on the Pharmacokinetics of a Single Dose of Caffeine in Healthy ParticipantsCompletedNCT04655040Phase 1
• Effect of Caffeine Supplementation and Personalized Insoles on FemalesSuspendedNCT04642131Not applicable
• Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19CompletedNCT04570254Not applicable
• Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years OldActive, not recruitingNCT04551170Phase 2
• Efficacy of Pentoxifylline as Add on Therapy in COVID19 PatientsWithdrawnNCT04433988Phase 1/2
• Treatment of Bipolar Depression With PentoxifyllineCompletedNCT04417049Early Phase 1
• Real-Time Caffeine Optimization During Total Sleep DeprivationCompletedNCT04399083Not applicable
• HEMolysis in a Percutaneous Axial Flow LVAD, Effects of Pentoxifylline in a Randomized Controlled TrialWithdrawnNCT04391231Phase 4
• Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary SyndromeCompletedNCT04367935Phase 2/3
• Theophylline for Depression StudyWithdrawnNCT04309877Early Phase 1
• Effect of Creatine and Caffeine on Muscle PerformanceStatus unknownNCT04290819Not applicable
• Caffeine Study for Pain Control Following Total Joint ReplacementStatus unknownNCT04280263Not applicable
• Diaphragmatic Ultrasound With Theophylline Therapeutic TrialsStatus unknownNCT04269187Early Phase 1
• Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture HeadacheCompletedNCT04257851Phase 4
• Impact of AMATEA™️ on Physiological Measures and Gaming Performance in Active Gamers: a Placebo Controlled, Double-blind, Randomized StudyCompletedNCT04234529Not applicable
• Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute PulpitisCompletedNCT04202406Not applicable
• Effect of Papaverine on Renal Artery Blood Flow VolumeCompletedNCT04162834Phase 4
• Pentoxifylline Dose Optimization in Neonatal SepsisCompletedNCT04152980Phase 3
• The Effect of Preoperative AminophyllineStatus unknownNCT04151381Phase 1
• Sphenopalatine Blockade Versus Clinical TreatmentStatus unknownNCT04148846Not applicable
• Caffeine as Respiratory Stimulant in Preterm InfantsStatus unknownNCT04144712Phase 1
• Timing of Meal and Caffeine Intake on Substrate Use and Exercise EfficiencyCompletedNCT04106752Not applicable
• Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic SchizophreniaCompletedNCT04094207Phase 1/2
• Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALSActive, not recruitingNCT04057898Phase 2/3
• Lipodystrophy and Fat Metabolism During ExerciseWithdrawnNCT04056000Not applicable
• Relative Bioavailability of MN-166 (Ibudilast) in Extended Release Tablet vs. Intermediate-release Capsule in Healthy VolunteersCompletedNCT04054206Phase 1
• Caffeine Treatment in in the Delivery RoomCompletedNCT04044976Not applicable
• The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery DiameterCompletedNCT04030663Early Phase 1
• Effect of Early Use of Caffeine Citrate in Preterm NeonatesCompletedNCT04001712Phase 3
• Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the Treatment of Post-dural Puncture HeadacheCompletedNCT03997006Phase 4
• A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or RosuvastatinCompletedNCT03970798Phase 1
• The Effects of a Combination of TeaCrine®, Dynamine, and Caffeine in Law EnforcementCompletedNCT03937687Early Phase 1
• Preventing Acute Kidney Injury (AKI) in Pediatric PatientsStatus unknownNCT03897335Phase 3
• Exogenous Ketone Supplementation and Exercise PerformanceStatus unknownNCT03895892Not applicable
• The Effect of Doxapram Versus Theophylline on Diaphragmatic FunctionStatus unknownNCT03894189Not applicable
• Topical Pentoxifylline Gel on Behcet's Disease Oral UlcersCompletedNCT03888846Phase 2
• Efficacy Of Doxophylline As A Sparing Treatment For Inhaled Corticosteroids In Mexican Children With AsthmaStatus unknownNCT03879590Phase 3
• Pentoxifylline in Lupus NephritisWithdrawnNCT03859570Phase 4
• Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung MetastasesActive, not recruitingNCT03824327Phase 1
• The Influence of Caffeine Supplementation on Specific Performance and Training ActivitiesCompletedNCT03822663Phase 3
• Pentoxifylline Administration in Hemodialysis PatientsStatus unknownNCT03800433Early Phase 1
• Study to Evaluate Ibudilast and TMZ Combo Treatment in Newly Diagnosed and Recurrent GlioblastomaCompletedNCT03782415Phase 1/2
• Influence of Flavonoids and Caffeine Supplementation on Resting MetabolismCompletedNCT03752125Not applicable
• Does Oral Pentoxifylline Administration Improve Hemoglobin in Hemodialysis Patients?CompletedNCT03731741Phase 2
• Effects of a Thermogenic Dietary Supplement on Metabolic, Hemodynamic, and Mood ResponsesCompletedNCT03678116Not applicable
• Caffeine Consumption in Glaucoma Patients and Healthy SubjectsCompletedNCT03675412Not applicable
• Pentoxifylline Effect in Patients With Diabetic Nephropathy.(PENFOSIDINE STUDY)Status unknownNCT03664414Phase 4
• Pentoxifylline in Diabetic Kidney DiseaseActive, not recruitingNCT03625648Phase 4
• Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity DisorderCompletedNCT03533556Early Phase 1
• Study of MN-166 (Ibudilast) Extended Release Tablet Formulations Compared With Capsules in Healthy VolunteersCompletedNCT03533387Phase 1
• Effects of Pentoxifylline and Vitamin E on Pregnancy Rate in Infertile Women Treated by ICSI:Status unknownNCT03476564Early Phase 1
• Erectile Recovery After Robotic-Assisted Laparoscopic ProstatectomyStatus unknownNCT03406169Phase 3
• Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD.CompletedNCT03388853Phase 4
• Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine UsersCompletedNCT03341078Phase 2
• Intermittent Hypoxia and Caffeine in Infants Born PretermCompletedNCT03321734Phase 2
• Effect of Caffeine on Ocular Circulation in High MyopesCompletedNCT03294967Not applicable
• Drug-drug Interaction Study Between EDP-305, Midazolam, Caffeine and Rosuvastatin in Healthy Volunteers.CompletedNCT03187496Phase 1
• Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and PravastatinCompletedNCT03131973Phase 1
• Digital Image Correlation in Right Ventricular EvaluationCompletedNCT03115294Not applicable
• Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?CompletedNCT03097900Phase 2
• Early Caffeine in Preterm NeonatesStatus unknownNCT03086473Phase 4
• Prostatic Hyperplasia Treatment and Cancer PreventionStatus unknownNCT03064282Early Phase 1
• Pentoxifylline and Lumbar RadiculopathyActive, not recruitingNCT03060434Phase 4
• Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)Active, not recruitingNCT03040778Phase 3
• Theophylline Treatment for PseudohypoparathyroidismActive, not recruitingNCT03029429Phase 2
• The Effects of Caffeine Withdrawal on MigraineTerminatedNCT03022838Phase 2/3
• Association Study Between CYP1A2 Gene Polymorphisms and Metabolism of TheophyllineCompletedNCT03015090Not applicable
• Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With NephropathyCompletedNCT03006952Phase 4
• Pentoxifylline for the Prevention of PEPStatus unknownNCT02992678Early Phase 1
• To Evaluate the Superiority of Fixed Combination (Orfenadrine 35mg, Acetaminophen 325mg, Caffeine 65mg and Diclofenac Sodium 50mg) Compared to Voltaren® (Diclofenac Sodium 50mg) in the Treatment of Acute Postural Low Back Pain.Status unknownNCT02985671Phase 3
• Effects of Aminophylline on Renal Function and Urine Volume of AKI PatientStatus unknownNCT02983422Early Phase 1
• Synergistic Effect of Vedolizumab and PentoxifyllineCompletedNCT02953275Early Phase 1

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