Phosphodiesterase Inhibitors: all 583 studies that test it

Page 5 of 6. Open to participants first (87), then studies with results posted, then the rest; newest registration first within each.

• The Protective Effect of Pentoxifylline on Acute Kidney InjuryStatus unknownNCT02951299Phase 2/3
• Effects of Caffeine on EEG Theta/Beta Ratio and Cognitive ControlCompletedNCT02940808Not applicable
• The Effects of Coffee Main Constituents (Caffeine and Chlorogenic Acid) Supplementation on Inflammatory, Metabolic Factors, Hepatic Steatosis and Fibrosis in None- Alcoholic Fatty Liver Patients With Type 2 DiabetesCompletedNCT02929901Phase 2/3
• Acute Caffeine Effects on Cardiac Autonomic and Cardiorespiratory Parameters Responses After Aerobic ExerciseStatus unknownNCT02917889Not applicable
• Vinpocetine Inhibits NF-κB-dependent Inflammation in Acute Ischemic Stroke PatientsCompletedNCT02878772Phase 2/3
• The Impact of Caffeine on Cognition in SchizophreniaCompletedNCT02832401Not applicable
• The Effect of Caffeine on the Narcoleptic PatientsCompletedNCT02832336Phase 1/2
• Effect of Caffeine Intake in Vestibular FunctionCompletedNCT02825199Phase 4
• Assessment of the Efficacy of Ocular Dipyridamole in the Treatment of Dry Eye Symptomology in Subjects With PterygiumStatus unknownNCT02782260Phase 2
• This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic ArthritisCompletedNCT02772601Phase 1
• Pharmacokinetic Drug-Drug Interaction Study of RucaparibCompletedNCT02740712Phase 1
• Optimal Analgesia in Acute GastroenteritisTerminatedNCT02711241Phase 3
• A Uremic Toxin Absorbent (AST-120) to Treat Hospital Acquired Acute Kidney InjuryStatus unknownNCT02687841Phase 3
• Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and DigoxinCompletedNCT02685462Phase 1
• A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral SclerosisCompletedNCT02655614Phase 1
• Oxidative Stress and Oxysterols Profiling in Patients With Carotid RevascularizationCompletedNCT02630862Not applicable
• Caffeine in Amblyopia StudyWithdrawnNCT02594358Phase 1/2
• The Effect of Caffeine on Acupuncture Analgesia With the Human Pain ModelCompletedNCT02577770Not applicable
• Early Versus Late Caffeine for ELBW NewbornsTerminatedNCT02524249Not applicable
• Aminophylline for Patients With Post-Dural Puncture HeadacheCompletedNCT02522013Phase 3
• A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid TumorsCompletedNCT02520752Phase 1
• Does Caffeine Reduce Postoperative Bowel Paralysis After Elective Colectomy?TerminatedNCT02510911Not applicable
• Pentoxifylline In Pediatric Acute Lymphoblastic Leukemia During InductionStatus unknownNCT02451774Phase 2/3
• Management of Apnea in Late Preterm and Term InfantsWithdrawnNCT02408328Phase 2
• The Impact of Pentoxifylline and Vitamin E on Radiotherapy-induced Toxicity in Head & Neck Cancer PatientsCompletedNCT02397486Phase 2
• Influence of a Bitter Compound and Bittermasking Compound on Gastric pHStatus unknownNCT02372188Not applicable
• Trial of Caffeine to Alleviate Dyspnea Related to TicagrelorTerminatedNCT02311088Phase 2
• The Effect of Pentoxifylline on Liver Function Tests in Fatty Liver DiseaseCompletedNCT02283710Phase 2
• Effect of BIIL 284 BS on the Pharmacokinetics of Theophylline in Healthy Male VolunteersCompletedNCT02273440Phase 1
• Study to Evaluate the Effect of Multiple Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Warfarin, Omeprazole, Caffeine, and Dextromethorphan in Healthy Male VolunteersCompletedNCT02256813Phase 1
• The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)CompletedNCT02254148Phase 1
• Caffeinated Gum to Prevent Post-Operative Ileus: A Prospective, Randomized, Placebo-controlled TrialWithdrawnNCT02250924Not applicable
• PPALM-Palm Oil and Pentoxifylline Against Late MorbidityCompletedNCT02230800Phase 2
• A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate CancerCompletedNCT02225093Phase 1
• Caffeine Disposition After InhalationCompletedNCT02184104Not applicable
• Acetylsalicylic Acid (ASA) + Paracetamol + Caffeine Combination Compared With ASA + Paracetamol as Well as ASA, Paracetamol, and Caffeine in Headache PatientsCompletedNCT02183688Phase 3
• Pentoxifylline and Late Onset Sepsis in Preterm InfantsCompletedNCT02163174Phase 3
• Metadoxine as a Therapy for Severe Alcoholic HepatitisCompletedNCT02161653Phase 4
• A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Repaglinide and CaffeineCompletedNCT02128321Phase 1
• EIMD Mechanisms Causing Force LossTerminatedNCT02125643Phase 1
• The Effects of Caffeine on Pain-Based Pacing During a Cycling Time-TrialCompletedNCT02115763Phase 1
• Caffeine, Genetic Variation and Athletic PerformanceStatus unknownNCT02109783Not applicable
• High Versus Low Dose of Caffeine for Apnea of PrematurityCompletedNCT02103777Phase 3
• Inhibition of VAP-1 by Caffeine in Healthy Human Volunteers StudyWithdrawnNCT02098785Phase 1
• A Study of Caffeine on Cardiac ArrhythmiasCompletedNCT02095405Not applicable
• Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced NephropathyStatus unknownNCT02088502Phase 2/3
• Influence of Caffeine on HRV and Exercise Performance in Spinal Cord InjuryCompletedNCT02083328Not applicable
• A Phase I Dose Escalation Study of Erlotinib in Combination With TheophyllineTerminatedNCT02080078Phase 1
• Effects of Modafinil, Caffeine and Methylphenidate in Healthy VolunteersCompletedNCT02071615Not applicable
• Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in ObesityCompletedNCT02048215Phase 3
• Arrhythmic Effects of Hight Dose CaffeineStatus unknownNCT02045992Not applicable
• Development of Ibudilast for Alcohol Use DisorderCompletedNCT02025998Phase 1
• Drug Interaction Study of Azithromycin and TheophyllineCompletedNCT02023554Not applicable
• Cognitive Effects of Vinpocetine in Healthy Adults and Patients With EpilepsySuspendedNCT02011971Phase 1/2
• Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV PatientsStatus unknownNCT02008214Phase 4
• Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of TheophyllineCompletedNCT02001935Not applicable
• Evaluation of the Effect of Fasting and Exercise on Uptake of Tc-99m Sestamibi in Breast TissueCompletedNCT01944215Phase 1
• Drug-Drug Interaction Study With PF-05089771CompletedNCT01934569Phase 1
• Bromocriptine and Pentoxifylline in Ophthalmopathy Autoimmune TreatmentTerminatedNCT01893450Not applicable
• Repeated Dose Study for the Investigation of Heritability of and Genetic Influences on Drug PharmacokineticsCompletedNCT01845194Phase 1
• Cognitive Hyper-performance - Effects of Stimulating Substances in Chess-playersCompletedNCT01834547Phase 1
• Caffein Consumption and Response InhibitionCompletedNCT01815203Not applicable
• Combination of gp96-Ig Vaccine, Theophylline and Oxygen for the Treatment of Patients With Advanced, Relapsed or Metastatic Non-Small Cell Lung CancerWithdrawnNCT01799161Phase 1
• A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High AltitudeCompletedNCT01794078Phase 1
• The Role of Theophylline Plus Low-dose Formoterol-budesonide in Treatment of BronchiectasisCompletedNCT01769898Phase 4
• Caffeine as a Therapy for Parkinson's DiseaseCompletedNCT01738178Phase 3
• The Effect of Leptin A-200, Caffeine/Ephedrine and Their Combination Upon Weight Loss and Body Composition in ManCompletedNCT01710722Not applicable
• The Effects of Caffeine on Vestibular Evoked Myogenic Potentials in Healthy SubjectsStatus unknownNCT01693809Phase 4
• The Effect of Theophylline in the Treatment of BronchiectasisCompletedNCT01684683Phase 4
• The Impact of the Routine Aminophylline Administration Following Regadenoson Stress on SPECT Myocardial PerfusionWithdrawnNCT01655524Phase 4
• Metformin-Dipyridamole Interaction TrialCompletedNCT01613755Phase 4
• Low-dose Theophylline as Anti-inflammatory Enhancer in Severe Chronic Obstructive Pulmonary DiseaseCompletedNCT01599871Phase 3
• Treatment of Low Metabolic Rate Following Bariatric SurgeryCompletedNCT01596907Not applicable
• Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid TumorsCompletedNCT01596647Phase 1
• Aminophylline and Contrast Induced Nephropathy in Acute Myocardial InfarctionCompletedNCT01594489Phase 4
• Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-EchodopplerStatus unknownNCT01593644Phase 2
• Caffeine and Sodium Citrate IngestionCompletedNCT01591226Not applicable
• The Safety Evaluation of Drug Combinations Against High Altitude Pulmonary HypertensionCompletedNCT01566565Phase 1
• Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS)Status unknownNCT01542268Phase 4
• Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer SubjectsCompletedNCT01517399Phase 1
• Effects of Caffeine in Hydration and Energy MetabolismCompletedNCT01477294Not applicable
• Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) DiseasesCompletedNCT01472263Phase 3
• Evaluating the Protective Effect of Pentoxifylline on Contrast Induced NephropathyStatus unknownNCT01469624Not applicable
• Add-on Study of Pentoxifylline in Cutaneous LeishmaniasisCompletedNCT01464242Phase 2/3
• Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus PentoxifyllineStatus unknownNCT01455337Phase 3
• Interaction of Caffeine and Hydration on VoiceCompletedNCT01435837Early Phase 1
• Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in Young InfantsCompletedNCT01435486Not applicable
• Ibuprofen Versus Ibuprofen Plus Caffeine in the Treatment of Migraine.WithdrawnNCT01426971Phase 3
• Clinical Study of Caffeine for Apnea of PrematurityCompletedNCT01408173Phase 3
• Ibudilast in the Treatment of Patients With Chronic Migraine.CompletedNCT01389193Phase 1
• Antimony Plus Pentoxifylline in Cutaneous LeishmaniasisCompletedNCT01381055Phase 2/3
• Cognitive and Cerebral Blood Flow Effects of 2-week Caffeine Abstinence or MaintenanceCompletedNCT01376882Not applicable
• Effects of Pentoxiphylline on Left Ventricular (LV) Systolic Function Indices and Circulating Biomarkers in Patients With Chronic Congestive Heart Failure (CHF)WithdrawnNCT01337349Not applicable
• Ibudilast in the Treatment of Medication Overuse HeadacheStatus unknownNCT01317992Phase 1/2
• Can Dipyridamole Induce Protection Against Ischemia and Reperfusion Injury in Patients Undergoing Elective Coronary Artery Bypass Grafting (CABG)?CompletedNCT01295567Phase 4
• Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial PlexopathyCompletedNCT01291433Phase 3
• Effects of Theobromine and Caffeine on Mood, Cognition and Blood PressureCompletedNCT01288547Not applicable
• Adenosine Activity in Producing Venoarteriolar ReflexesStatus unknownNCT01280071Not applicable
• Vitamin E Versus Vitamin E Plus Pentoxiphyllin in Patients With Nonalcoholic Steatohepatitis: A Prospective Randomized Clinical TrialWithdrawnNCT01279434Not applicable
• Pentoxifylline and Systemic Inflammation in Hemodialysis PatientsCompletedNCT01269827Phase 4

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