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Status unknownNCT05354999Updated Aug 12, 2022

Effects of Combinations of Performance-enhancing Supplements on Exercise Performance

An interventional study of Sodium bicarbonate and caffeine in Healthy, sponsored by Morten Hostrup, PhD. Status unknown at 1 site in Denmark. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-08-12.

Sponsored by Morten Hostrup, PhD · Not applicable, Interventional, and Basic science

The sponsor has not verified this record recently (last verified Aug 2022), so the status shown — last known as Active, not recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
23
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

The purpose of the study is to investigate the effect of combinations of creatine monohydrate, sodium bicarbonate and caffeine on exercise performance and fatigability.

02

Conditions studied

  • Healthy

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Keywords

  • Exercise
  • Performance
  • Supplementation
03

In context

Motor Activity

2,646 studies on the registry are indexed under Motor Activity; 1,205 are open to participants now.

This study's enrollment of 23 is below the median of 60 across 2,309 interventional studies indexed under Motor Activity.

Browse Motor Activity studies →

Lead sponsor

Morten Hostrup, PhD is the lead sponsor of 17 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Healthy
  • VO2max of >50 ml/min/kg for men and >45 ml/min/kg for women
  • Performs endurance training >3 times per week

Exclusion criteria

Exclusion Criteria:

  • Chronic disease deemed by the study responsible medical doctor to interfere with any part of the study
  • Smoking
  • Chronic use of prescription medicine deemed by the study responsible medical doctor to interfere with any part of the study
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
23 participants (actual)

Study arms

  • Experimental
    Creatine

    Subjects ingest creatine monohydrate daily.

    Dietary Supplement: Sodium bicarbonate and caffeine

  • Placebo comparator
    Placebo

    Subjects ingest placebo daily.

    Dietary Supplement: Sodium bicarbonate and caffeine

Interventions

  • Dietary supplementSodium bicarbonate and caffeine

    Drug pages: Sodium Bicarbonate · Caffeine

    On experimental days subjects ingest a combination of sodium bicarbonate, caffeine and placebo.

06

What researchers measure

Primary outcomes

  1. Work performed (kJ/Watt)

    Work performed during a 6 minute time trial

    Time frame: Measured at each trial throughout the study, on average 4 weeks

Secondary outcomes

  1. Work performed (kJ/Watt)

    Work performed during a 15 second sprint test

    Time frame: Measured at each trial throughout the study, on average 4 weeks

  2. Muscle strength (Nm)

    Maximal voluntary isometric contraction of m. quadriceps femoris

    Time frame: Measured at each trial throughout the study, on average 4 weeks

07

Study locations

1 site
  • August Krogh Building
    Copenhagen, 2100, Denmark
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Apr 2022 (actual). Primary completion is estimated for Mar 2023, 11 months after the start.

Of 1,726 non-industry interventional studies with no phase under Motor Activity, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 47. This study's planned 11 months is below that.

Counting every sponsor, half of 1,738 studies reached it within 23 months; a quarter within 9 and three quarters within 47.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 18, 2022
First posted
May 2, 2022
StartActual
Apr 18, 2022
Primary completionEst.
Mar 2023
CompletionEst.
Dec 2023
Last update
Aug 12, 2022
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 12, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05354999
Lead sponsor
Morten Hostrup, PhD
Responsible party
Morten Hostrup, PhD (Associate Professor, University of Copenhagen) — Sponsor-investigator
First posted
May 2, 2022
Start date
Apr 18, 2022
Primary completion
Mar 2023 (estimated)
Completion
Dec 2023 (estimated)
Last update
Aug 12, 2022

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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Discussion

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Studies of the drugs tested here: Sodium Bicarbonate · Caffeine

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Morten Hostrup, PhD

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