SupplementDrug
Cholecalciferol clinical trials
Also written Vitamin D3, Calciol and Colecalciferol.
Related medicines add 2 studies
Counted the way a researcher would: Cholecalciferol with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Cholecalciferol is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Approvals
The first approval found in each region, with its record
- United States
- 18 May 2000 · INFUVITE ADULT · NDA 021163 (FDA, Drugs@FDA; in a combination)
- European Union
- 24 Aug 2005 · Fosavance · EMEA/H/C/000619 (EMA; in a combination)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Name
Studies by the year they started
704 studies that test it; most in 2011 (68)
| Year | Studies |
|---|---|
| 2001 | 1 |
| 2002 | 1 |
| 2003 | 4 |
| 2004 | 4 |
| 2005 | 5 |
| 2006 | 11 |
| 2007 | 18 |
| 2008 | 39 |
| 2009 | 43 |
| 2010 | 57 |
| 2011 | 68 |
| 2012 | 58 |
| 2013 | 39 |
| 2014 | 41 |
| 2015 | 44 |
| 2016 | 34 |
| 2017 | 28 |
| 2018 | 33 |
| 2019 | 24 |
| 2020 | 28 |
| 2021 | 32 |
| 2022 | 28 |
| 2023 | 12 |
| 2024 | 19 |
| 2025 | 19 |
| 2026 | 14 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 15 · Other 690
Brigham and Women's Hospital (15) · Medical University of South Carolina (11) · Emory University (10) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (9) · Massachusetts General Hospital (9) · Mayo Clinic (8) · Ain Shams University (8) · Roswell Park Cancer Institute (8)
Often tested with
Tested in the same studies.
Omega-3 fatty acid (19) · Ergocalciferols (15) · Calcium Carbonate (9) · Calcium (8) · Fish Oils (7) · Ascorbic Acid (7) · Zinc (7) · Selenium (6)
Related medicines
As reviewed, each with the page that says it.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 21, 2 in phase 3
Studies that test Cholecalciferol, phase 3 first.
- Jul 2027The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill PatientsPhase 3 · Medical University of Graz
- Oct 2027VITAL Rhythm StudyPhase 3 · Brigham and Women's Hospital
- Nov 2026Vitamin D3 Versus Methotrexate Versus Saline Injections for Plantar WartsNot applicable · Kafrelsheikh University
- Dec 2026Temporal Profile of Serum Vitamin D Levels in Foot and Ankle Fusion SurgeryEarly Phase 1 · Prisma Health-Midlands
- Dec 2026Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18 (VITAL Infection)Not applicable · Brigham and Women's Hospital
- Dec 2026Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient PatientsPhase 2 · Wake Forest University Health Sciences
- Dec 2026High-dose Vitamin D Supplements in Older AdultsPhase 2 · University of California, Davis
- Dec 2026Effects of Vitamin D and Prebiotic Supplementation on Glucose Control During PregnancyNot applicable · Huazhong University of Science and Technology
- Dec 2026Vitamin D Replacement in BronchiectasisPhase 4 · Queen Mary Hospital, Hong Kong
- Mar 2027Evaluating the Impact of Vitamin D Supplementation on Healing Bed Sores in ICU.Not applicable · Maha Salah
Studies
Open first, then newest update. How each study uses Cholecalciferol is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 705
- Intra-articular Vitamin D3 Injection for Patients With Temporomandibular Joint OsteoarthritisEnrolling by invitationNot applicableCairo UniversityNCT07929103Written as Vitamin D3 (Cholecalciferol)
- Vitamin D3 Versus Methotrexate Versus Saline Injections for Plantar WartsRecruitingNot applicableKafrelsheikh UniversityNCT07937007Written as Cholecalciferol (Vit D3)
- Role of Vitamin D Supplementation in Children With Irritable Bowel SyndromeRecruitingNot applicableAziz Bhatti Shaheed Teaching HospitalNCT07914478Written as Vitamin D3
- Effect of Vitamin D Supplementation Added to Iron Therapy in Children With Iron Deficiency AnemiaNot yet recruitingNot applicableAlFayhaa General HospitalNCT07892170Written as Vitamin D3 2000 IU/day
- Effect of Vitamin D3 Supplementation on Serum Sphingosine-1-Phosphate Levels and Dental Implant Osseointegration: A Prospective StudyNot yet recruitingNot applicableAir Force Military Medical University, ChinaNCT07883811Written as Vitamin D3 ( Colecalciferol)
- Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer PatientsRecruitingEarly Phase 1Mayo ClinicNCT05045066Written as Cholecalciferol
- Evaluating the Impact of Vitamin D Supplementation on Healing Bed Sores in ICU.RecruitingNot applicableMaha SalahNCT07813975Written as Enteral Vit-D 3 (cholecalciferol)
- Multiple Adjunct Therapies to Improve Immunotherapy Treatment in Patients With Locally Advanced or Metastatic Melanoma or Advanced Hepatocellular CancerNot yet recruitingPhase 2University of Southern CaliforniaNCT07836712Written as Cholecalciferol
- The Efficacy of Vitamin D Supplementation to Sustain Performance OutcomesRecruitingNot applicableWalter Reed Army Institute of Research (WRAIR)NCT07654777Written as Vitamin D3 (Cholecalciferol)
- Supplementation Absorption ComparisonRecruitingPhase 4RDC Clinical Pty LtdNCT07791797Written as Plexosome® Vitamin D3
- Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient PatientsRecruitingPhase 2Wake Forest University Health SciencesNCT04677816Written as Vitamin D3
- Vitamin D3 Supplementation Regimens and Preeclampsia RiskRecruitingNot applicableSana'a UniversityNCT07648706Written as Vitamin D3
- COMPARISON OF THE EFFICACY BETWEEN PREOPERATIVE CALCIUM & VITAMIN D3 VERSUS CALCIUM SUPPLEMENTATION ALONE TO PREVENT POST OPERATIVE SYMPTOMATIC HYPOCALCEMIA AFTER TOTAL THYROIDECTOMY IN EUTHYROID PATIENTSNot yet recruitingNot applicableKing Edward Medical UniversityNCT07597096Written as Calcium carbonate plus vitamin D3 (cholecalciferol)
- Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver MetastasesRecruitingEarly Phase 1Dana-Farber Cancer InstituteNCT02172651Written as Vitamin D3
- Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT)RecruitingPhase 2Lagos State UniversityNCT07269457Written as Vitamin D3 (Cholecalciferol)
- Vitamin D Treat-to-Target Strategy for Children With Overactive Bladder-WetRecruitingNot applicableChildren's Hospital of Chongqing Medical UniversityNCT06201013Written as Vitamin D3
- Vitamin D Supplementation Among Pregnant Women in Uganda for the Prevention of Hypertensive Disorders in Pregnancy, and Other Adverse Maternal and Foetal OutcomesNot yet recruitingPhase 4St Mary's Hospital, LacorNCT07510568Written as oral 2.000 IU vitamin D3 (cholecalciferol) daily, in addition to routine ANC supplementations
- Effects of Vitamin D3 and Yeast Beta-Glucan Supplementation on Glycemic Control and Cardiovascular Disease Risk in Patients With Type 2 DiabetesRecruitingNot applicableHuazhong University of Science and TechnologyNCT06861062Written as Vitamin D3
- The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage IIIRecruitingPhase 3Ottawa Hospital Research InstituteNCT04871412Written as Vitamin D3 Drops
- Effects of Vitamin D and Prebiotic Supplementation on Glucose Control During PregnancyRecruitingNot applicableHuazhong University of Science and TechnologyNCT06553729Written as Vitamin D3
See all 705 studies that test Cholecalciferol →
Given beside what is tested · 53 — Cholecalciferol is usual care or a partner of the new treatment
- Effects of Cofrogliptin on Beta-Cell Function in LADA PatientsNot yet recruitingNot applicableSecond Xiangya Hospital of Central South UniversityNCT07460336Written as Vitamin D3
- Triamcinolone With Vitamin D Synergistic Efficacy in PsoriasisRecruitingEarly Phase 1Wright State UniversityNCT04036188Written as Vitamin D3
- Vitamin A and D Supplementation in Allogeneic HCTRecruitingPhase 2St. Petersburg State Pavlov Medical UniversityNCT06508099Written as Vitamin D3
- Efficacy and Safety of Oral Ibandronate in Patients of Liver Cirrhosis With Hepatic Osteodystrophy.Not yet recruitingNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT06022237Written as Vitamin D3
- RANKL Inhibition and Mammographic Breast DensityActive, not recruitingPhase 2Washington University School of MedicineNCT04067726Written as Vitamin D3
- Novel Combination Therapy for Osteoporosis in MenCompletedPhase 4VA Office of Research and DevelopmentNCT03994172Written as Vitamin D3
- A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 DiabetesTerminatedPhase 3Diamyd Medical ABNCT05018585Written as Colecalciferol 2000 IU
- Prophylactic Effect of Probiotic Streptococcus Salivarius eK12 Against Recurrent Streptococcus Pyogenes Pharyngotonsillitis Infection in PediatricsCompletedNot applicableLiaquat University of Medical & Health SciencesNCT06370208Written as Oral vit D3
- Pilot Study of OMEGA-3 and Vitamin D in High-Dose in Type I Diabetic PatientsCompletedPhase 1/2Rodolfo AlejandroNCT03406897Written as Cholecalciferol
- Bone Mass and Strength After Kidney TransplantationCompletedPhase 2Columbia UniversityNCT02224144Written as Vitamin D3
- Trial of Combination Therapy to Treat COVID-19 InfectionCompletedPhase 1ProgenaBiomeNCT04482686Written as Vitamin D3
- A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018)TerminatedPhase 3Merck Sharp & Dohme LLCNCT00529373Written as Vitamin D3
- Effect of Laser Acupuncture on Forearm Bone Mineral Density and Wrist Pain in Osteoporotic Postmenopausal WomenCompletedNot applicableCairo UniversityNCT05559619Written as Vitamin D3
- Heartland Osteoporosis Prevention StudyCompletedPhase 3University of NebraskaNCT02186600Written as Vitamin D3
- Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19TerminatedPhase 2Marvin McCreary, MDNCT04400890Written as Vitamin D3
- Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic KeratosesCompletedPhase 2Case Comprehensive Cancer CenterNCT04140292Written as Vitamin D3
- Alendronate for Prevention of AntiRetroviral Therapy-associated Bone LossTerminatedPhase 4University College DublinNCT02322099Written as calcium carbonate and colecalciferol
- Oral Vitamin D and Toll Like Receptor in Spondylitis TuberculosisStatus unknownPhase 2/3Hasanuddin UniversityNCT05376189Written as 400 IU
- Pilot Study for Zoledronic Acid to Prevent Bone Loss After Bariatric SurgeryCompletedPhase 4Massachusetts General HospitalNCT03424239Written as Vitamin D3
- Effects of Bisphosphonates and Nutritional Supplementation After a Hip FractureCompletedNot applicableKarolinska InstitutetNCT01950169Written as Calcium and vitamin D3
Showing 20 of 53.
As the comparator · 22 — what is tested is compared with Cholecalciferol
- VitD3 Supplementation in Patients With Multiple MyelomaRecruitingEarly Phase 1Amany Keruakous, MD, MS.NCT05846880Written as No maintenance Vitamin D
- Vitamin D Supplementation on Reported Rates of Taxane-Induced NeuropathySuspendedPhase 2Virginia Commonwealth UniversityNCT05259527Written as Cholecalciferol Capsules
- Efficacy and Safety of Combination Denosumab With Eldecalcitol for Postmenopausal Women With Osteoporosis.(ESCORT)CompletedPhase 4Xi'an Honghui HospitalNCT05884372Written as Native Vitamin D
- Vitamin D and COVID-19 ManagementCompletedPhase 3University of AlbertaNCT04385940Written as Vitamin D3
- The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the TherapeuticCompletedPhase 2Mansoura UniversityNCT06669026Written as vitamin D3 gel (regular non-nanoparticle form)
- Pharmacokinetics of Calcifediol and CholecalciferolCompletedNot applicableDSM Nutritional Products, Inc.NCT02333682Written as Vitamin D3 (Cholecalciferol) 20 mcg
- Pearlium®/Effecti-Cal®, a Novel Formulation of Calcium, Vitamin D and Minerals for Prevention of Postmenopausal Bone LossCompletedPhase 4University of AlbertaNCT04609189Written as Calcium carbonate/vitamin D3
- Oral Vitamin D and Toll Like Receptor in Spondylitis TuberculosisStatus unknownPhase 2/3Hasanuddin UniversityNCT05376189Written as 400 IU
- Gastrointestinal Tolerance Assessment of T2309CompletedNot applicableLaboratoires TheaNCT04596605Written as Nutrof Total
- Vitamin D 24'000 IU for Oral Intermittent SupplementationCompletedPhase 3University Hospital, Basel, SwitzerlandNCT03920150Written as Vitamin D3
- To Test the Effect of Calcifediol Hy.D Supplementation on Muscle Function and Bone Quality in Younger Postmenopausal Women With OsteopeniaCompletedPhase 2DSM Nutritional Products, Inc.NCT02527668Written as Vitamin D3
- Vitamin D Supplementation After Parathyroid SurgeryCompletedNot applicableKarolinska University HospitalNCT00982722Written as cholecalciferol and calcium carbonate
- Evaluation of a Transdermal Vitamin D3 Delivery System, D3forMEWithdrawnNot applicableUniversity of Wisconsin, MadisonNCT02174718Written as Oral vitamin D3
- HDDO-1614 Bio Equivalence StudyCompletedPhase 1Hyundai Pharmaceutical Co., LTD.NCT03382314Written as Bazedoxifene / Cholecalciferol
- HDDO-1614 Intervention TrialCompletedPhase 1Hyundai Pharmaceutical Co., LTD.NCT03234244Written as Cholecalciferol
- Availability of Vitamin D in Orange JuiceCompletedNot applicableBoston UniversityNCT01778114Written as Vitamin D3
- Evaluating Vitamin D Content in MushroomsCompletedNot applicableBoston UniversityNCT01815437Written as Cholecalciferol
- Effects of Genistein Aglycone in Glucocorticoid Induced OsteoporosisStatus unknownPhase 2/3University of MessinaNCT03040531Written as Calcium + vitamin D3 tablet
- Safety and Pharmacokinetic Characteristics of DP-R206(Vitamin D3) in Healthy Adult VolunteersCompletedPhase 1Alvogen KoreaNCT01577849Written as Vitamin D3
- Cholecalciferol Versus Doxercalciferol in the Treatment of Secondary Hyperparathyroidism in Chronic Kidney DiseaseCompletedNot applicableIndiana University School of MedicineNCT00285467Written as Cholecalciferol
Showing 20 of 22.
What changed recently
From the registry's own updates since Oct 16, 2026.
Stopped1
- The Vitamin D in Pediatric Crohn's Disease ( ViDiPeC-2 )TerminatedOct 21, 2026NCT03999580
Newly registered8
- Vitamin D3 Versus Methotrexate Versus Saline Injections for Plantar WartsNov 13, 2026NCT07937007
- Intra-articular Vitamin D3 Injection for Patients With Temporomandibular Joint OsteoarthritisNov 10, 2026NCT07929103
- Vitamin D3 for Psychological Distress, Dyspepsia Burden and Heart Rate Variability in Functional DyspepsiaNov 6, 2026NCT07922473
- Role of Vitamin D Supplementation in Children With Irritable Bowel SyndromeNov 3, 2026NCT07914478
- Vitamin D3 and Monocyte Responses in Pregnant Women With Pulmonary TuberculosisOct 30, 2026NCT07907094
Show 3 moreShow fewer
- Effect of Cholecalciferol on Mucin-1 Levels in Urinary Extracelllular Vesicles in Individuals With Autosomal Dominant Tubulo-Interstitial Kidney Disease Due to MUC1 Mutations (ADTKD-MUC1)Oct 29, 2026NCT07903909
- Effect of Vitamin D Supplementation Added to Iron Therapy in Children With Iron Deficiency AnemiaOct 23, 2026NCT07892170
- Effect of Vitamin D3 Supplementation on Serum Sphingosine-1-Phosphate Levels and Dental Implant Osseointegration: A Prospective StudyOct 20, 2026NCT07883811
Codes
What other systems call Cholecalciferol · ClinicalTrials.gg INT007209
- MeSH (NLM) D002762CholecalciferolConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 1C6V77QF41CHOLECALCIFEROLConfirmed FDA, NLM, Wikidata
- RxNorm 2418Confirmed FDA, Wikidata
- Wikidata Q139347cholecalciferolConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C48194CholecalciferolOne source FDA
- DrugBank DB00169One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D002762 | Cholecalciferol | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 1C6V77QF41 | CHOLECALCIFEROL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2418 | — | Confirmed FDA, Wikidata |
| Wikidata | Q139347 | cholecalciferol | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C48194 | Cholecalciferol | One source FDA |
| DrugBank | DB00169 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.